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Tom Huxford

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionSan Diego State University
DepartmentChemistry & Biochemistry
Address5500 Campanile Dr
CSL 325A
San Diego CA 92182
Phone6195941606
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhu N, Rogers WE, Heidary DK, Huxford T. Structural and biochemical analyses of the nuclear I?B? protein in complex with the NF-?B p50 homodimer. Genes Dev. 2024 Jul 19; 38(11-12):528-535. PMID: 38960718.
      Citations: 1     Fields:    Translation:HumansCells
    2. Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun. 2024 May 06; 15(1):3785. PMID: 38710674.
      Citations:    Fields:    Translation:HumansCells
    3. Borar P, Biswas T, Chaudhuri A, Huxford T, Chakrabarti S, Ghosh G, Polley S. Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate I?Ba through a phosphoenzyme intermediate. bioRxiv. 2024 Mar 28. PMID: 37732175.
      Citations:    
    4. Neal CL, Kronert WA, Camillo JRT, Suggs JA, Huxford T, Bernstein SI. Aging-affiliated post-translational modifications of skeletal muscle myosin affect biochemical properties, myofibril structure, muscle function, and proteostasis. Aging Cell. 2024 06; 23(6):e14134. PMID: 38506610.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Res Sq. 2024 Feb 23. PMID: 38464189.
      Citations:    
    6. Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. bioRxiv. 2024 Jan 23. PMID: 38260668.
      Citations:    
    7. Zhu N, Mealka M, Mitchel S, Milani C, Acu?a LM, Rogers E, Lahana AN, Huxford T. X-ray Crystallographic Study of Preferred Spacing by the NF-?B p50 Homodimer on ?B DNA. Biomolecules. 2023 08 26; 13(9). PMID: 37759710.
      Citations: 1     Fields:    Translation:Humans
    8. Holmberg R, Robinson M, Gilbert SF, Lujano-Olazaba O, Waters JA, Kogan E, Velasquez CLR, Stevenson D, Cruz LS, Alexander LJ, Lara J, Mu EM, Camillo JR, Bitler BG, Huxford T, House CD. TWEAK-Fn14-RelB Signaling Cascade Promotes Stem Cell-like Features that Contribute to Post-Chemotherapy Ovarian Cancer Relapse. Mol Cancer Res. 2023 02 01; 21(2):170-186. PMID: 36214671.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    9. Rana S, Kour S, Kizhake S, King HM, Mallareddy JR, Case AJ, Huxford T, Natarajan A. Dimers of isatin derived a-methylene-?-butyrolactone as potent anti-cancer agents. Bioorg Med Chem Lett. 2022 06 01; 65:128713. PMID: 35367592.
      Citations: 1     Fields:    Translation:Cells
    10. Ko MS, Cohen SN, Polley S, Mahata SK, Biswas T, Huxford T, Ghosh G. Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-?B through a targetable second interaction with upstream activator IKK2. J Biol Chem. 2022 05; 298(5):101864. PMID: 35339487.
      Citations: 7     Fields:    Translation:HumansCells
    11. Kour S, Rana S, Kizhake S, Lagund?in D, Klinkebiel D, Mallareddy JR, Huxford T, Woods NT, Natarajan A. Stapling proteins in the RELA complex inhibits TNFa-induced nuclear translocation of RELA. RSC Chem Biol. 2022 Jan 05; 3(1):32-36. PMID: 35128406.
      Citations:    
    12. Napoleon JV, Singh S, Rana S, Bendjennat M, Kumar V, Kizhake S, Palermo NY, Ouellette MM, Huxford T, Natarajan A. Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner. Chem Commun (Camb). 2021 May 11; 57(38):4678-4681. PMID: 33977973.
      Citations: 4     Fields:    Translation:HumansCells
    13. Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T. Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution. Biochim Biophys Acta Proteins Proteom. 2020 12; 1868(12):140526. PMID: 32853772.
      Citations: 3     Fields:    Translation:HumansCells
    14. Farokhi E, Fleming JK, Erasmus MF, Ward AD, Wu Y, Gutierrez MG, Wojciak JM, Huxford T. Ion Binding Properties of a Naturally Occurring Metalloantibody. Antibodies (Basel). 2020 Apr 16; 9(2). PMID: 32316193.
      Citations:    
    15. Caldwell JT, Mermelstein DJ, Walker RC, Bernstein SI, Huxford T. X-ray Crystallographic and Molecular Dynamic Analyses of Drosophila melanogaster Embryonic Muscle Myosin Define Domains Responsible for Isoform-Specific Properties. J Mol Biol. 2020 01 17; 432(2):427-447. PMID: 31786266.
      Citations: 2     Fields:    Translation:AnimalsCells
    16. Mulero MC, Wang VY, Huxford T, Ghosh G. Genome reading by the NF-?B transcription factors. Nucleic Acids Res. 2019 11 04; 47(19):9967-9989. PMID: 31501881.
      Citations: 38     Fields:    Translation:HumansCells
    17. Maniaci B, Lipper CH, Anipindi DL, Erlandsen H, Cole JL, Stec B, Huxford T, Love JJ. Design of High-Affinity Metal-Controlled Protein Dimers. Biochemistry. 2019 04 30; 58(17):2199-2207. PMID: 30938154.
      Citations: 1     Fields:    Translation:Cells
    18. Mulero MC, Huxford T, Ghosh G. NF-?B, I?B, and IKK: Integral Components of Immune System Signaling. Adv Exp Med Biol. 2019; 1172:207-226. PMID: 31628658.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    19. Mulero MC, Shahabi S, Ko MS, Schiffer JM, Huang DB, Wang VY, Amaro RE, Huxford T, Ghosh G. Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor ?B RelA Subunit. Biochemistry. 2018 05 22; 57(20):2943-2957. PMID: 29708732.
      Citations: 8     Fields:    Translation:HumansCells
    20. King AN, Fleming JK, Knapik SS, Visentin B, Wojciak JM, Huxford T. High-affinity pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis. J Lipid Res. 2017 07; 58(7):1386-1398. PMID: 28507038.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    21. Geronimo I, Denning CA, Rogers WE, Othman T, Huxford T, Heidary DK, Glazer EC, Payne CM. Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants. Biochemistry. 2016 06 28; 55(25):3594-606. PMID: 27267136.
      Citations: 6     Fields:    Translation:Cells
    22. Hauenstein AV, Rogers WE, Shaul JD, Huang DB, Ghosh G, Huxford T. Probing kinase activation and substrate specificity with an engineered monomeric IKK2. Biochemistry. 2014 Apr 01; 53(12):2064-73. PMID: 24611898.
      Citations: 4     Fields:    Translation:HumansCells
    23. Weerasinghe AJ, Amin SA, Barker RA, Othman T, Romano AN, Parker Siburt CJ, Tisnado J, Lambert LA, Huxford T, Carrano CJ, Crumbliss AL. Borate as a synergistic anion for Marinobacter algicola ferric binding protein, FbpA: a role for boron in iron transport in marine life. J Am Chem Soc. 2013 Oct 02; 135(39):14504-7. PMID: 24028339.
      Citations: 5     Fields:    Translation:Cells
    24. Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schr?felbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. A structural basis for I?B kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol. 2013; 11(6):e1001581. PMID: 23776406.
      Citations: 56     Fields:    Translation:HumansCells
    25. Caldwell JT, Melkani GC, Huxford T, Bernstein SI. Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system. Methods. 2012 Jan; 56(1):25-32. PMID: 22178692.
      Citations: 7     Fields:    Translation:Animals
    26. Fleming JK, Wojciak JM, Campbell MA, Huxford T. Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody. J Mol Biol. 2011 May 06; 408(3):462-76. PMID: 21392506.
      Citations: 15     Fields:    Translation:Cells
    27. Lee CF, Hauenstein AV, Fleming JK, Gasper WC, Engelke V, Sankaran B, Bernstein SI, Huxford T. X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster. Structure. 2011 Mar 09; 19(3):397-408. PMID: 21397190.
      Citations: 23     Fields:    Translation:AnimalsCells
    28. Huxford T, Hoffmann A, Ghosh G. Understanding the logic of I?B:NF-?B regulation in structural terms. Curr Top Microbiol Immunol. 2011; 349:1-24. PMID: 20845107.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    29. Wojciak JM, Zhu N, Schuerenberg KT, Moreno K, Shestowsky WS, Hiraiwa M, Sabbadini R, Huxford T. The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17717-22. PMID: 19815502.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    30. Huxford T, Ghosh G. A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harb Perspect Biol. 2009 Sep; 1(3):a000075. PMID: 20066103.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    31. Shaul JD, Farina A, Huxford T. The human IKKbeta subunit kinase domain displays CK2-like phosphorylation specificity. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):592-7. PMID: 18657515.
      Citations: 10     Fields:    Translation:HumansCells
    32. Trinh DV, Zhu N, Farhang G, Kim BJ, Huxford T. The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA. J Mol Biol. 2008 May 23; 379(1):122-35. PMID: 18436238.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    33. Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol. 2006 Jul 07; 360(2):421-34. PMID: 16756995.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    34. Huxford T, Ghosh G. Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. Methods Enzymol. 2006; 407:527-34. PMID: 16757350.
      Citations: 5     Fields:    Translation:HumansAnimals
    35. Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Bourne Y, Taylor P. Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica. J Mol Neurosci. 2006; 30(1-2):101-2. PMID: 17192647.
      Citations: 11     Fields:    Translation:AnimalsCells
    36. Bourne Y, Hansen SB, Sulzenbacher G, Talley TT, Huxford T, Taylor P, Marchot P. Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein. J Mol Neurosci. 2006; 30(1-2):103-4. PMID: 17192648.
      Citations: 3     Fields:    Translation:AnimalsCells
    37. Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y. Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J. 2005 Oct 19; 24(20):3635-46. PMID: 16193063.
      Citations: 287     Fields:    Translation:AnimalsCells
    38. Croy CH, Bergqvist S, Huxford T, Ghosh G, Komives EA. Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci. 2004 Jul; 13(7):1767-77. PMID: 15215520.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    39. Ghosh G, Huang DB, Huxford T. Molecular mimicry of the NF-kappaB DNA target site by a selected RNA aptamer. Curr Opin Struct Biol. 2004 Feb; 14(1):21-7. PMID: 15102445.
      Citations: 19     Fields:    Translation:Cells
    40. Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J Biol Chem. 2003 Jun 20; 278(25):23094-100. PMID: 12686541.
      Citations: 49     Fields:    Translation:Cells
    41. Huxford T, Mishler D, Phelps CB, Huang DB, Sengchanthalangsy LL, Reeves R, Hughes CA, Komives EA, Ghosh G. Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation. J Mol Biol. 2002 Dec 06; 324(4):587-97. PMID: 12460563.
      Citations: 17     Fields:    Translation:AnimalsCells
    42. Malek S, Chen Y, Huxford T, Ghosh G. IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells. J Biol Chem. 2001 Nov 30; 276(48):45225-35. PMID: 11571291.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    43. Huxford T, Malek S, Ghosh G. Preparation and crystallization of dynamic NF-kappa B.Ikappa B complexes. J Biol Chem. 2000 Oct 20; 275(42):32800-6. PMID: 10906335.
      Citations: 8     Fields:    Translation:AnimalsCells
    44. Phelps CB, Sengchanthalangsy LL, Huxford T, Ghosh G. Mechanism of I kappa B alpha binding to NF-kappa B dimers. J Biol Chem. 2000 Sep 22; 275(38):29840-6. PMID: 10882738.
      Citations: 37     Fields:    Translation:HumansCells
    45. Huxford T, Malek S, Ghosh G. Structure and mechanism in NF-kappa B/I kappa B signaling. Cold Spring Harb Symp Quant Biol. 1999; 64:533-40. PMID: 11232330.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    46. Huxford T, Huang DB, Malek S, Ghosh G. The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell. 1998 Dec 11; 95(6):759-70. PMID: 9865694.
      Citations: 202     Fields:    Translation:Cells
    47. Malek S, Huxford T, Ghosh G. Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB. J Biol Chem. 1998 Sep 25; 273(39):25427-35. PMID: 9738011.
      Citations: 44     Fields:    Translation:Cells
    48. Huang DB, Huxford T, Chen YQ, Ghosh G. The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits. Structure. 1997 Nov 15; 5(11):1427-36. PMID: 9384558.
      Citations: 26     Fields:    Translation:Cells
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