Sirolimus

"Sirolimus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Descriptor ID	D020123
MeSH Number(s)	D02.540.505.760
Concept/Terms	Sirolimus Sirolimus Rapamycin I-2190A I-2190A I 2190A I2190A AY 22-989 AY 22-989 AY 22 989 AY 22989 Rapamune Rapamune

Below are MeSH descriptors whose meaning is more general than "Sirolimus".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Lactones [D02.540]
Macrolides [D02.540.505]
Sirolimus [D02.540.505.760]

Below are MeSH descriptors whose meaning is related to "Sirolimus".

Below are MeSH descriptors whose meaning is more specific than "Sirolimus".

Sirolimus
Everolimus

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sirolimus" by people in this website by year, and whether "Sirolimus" was a major or minor topic of these publications.

Bar chart showing 63 publications over 26 distinct years, with a maximum of 9 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2000	0	1	1
2001	0	1	1
2002	1	0	1
2003	2	0	2
2004	1	1	2
2005	0	4	4
2006	1	2	3
2007	0	1	1
2008	6	3	9
2009	2	2	4
2010	1	1	2
2011	1	2	3
2012	0	4	4
2013	2	1	3
2014	1	3	4
2015	3	2	5
2016	2	1	3
2017	0	1	1
2019	1	1	2
2020	0	2	2
2021	0	1	1
2022	0	1	1
2023	1	0	1
2024	1	0	1
2025	1	0	1

Below are the most recent publications written about "Sirolimus" by people in Profiles.

Gonz?lez-Ch?vez SA, Chaparro-Barrera E, Loya-Rivera M, Rodr?guez-Castillo AJ, Prieto-Carrasco R, Aguilera RJ, Betancourt AP, Mohl JE, Ruizesparza-Hinojos DA, Ram?rez-P?rez SJ, Berm?dez M, Pacheco-Tena C. Rapamycin reveals neuropeptide Y as a regulator of senescence and inflammatory pathways in arthritis. Neuropeptides. 2025 Aug; 112:102533.

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Yamaguchi S, Sedaka R, Kapadia C, Huang J, Hsu JS, Berryhill TF, Wilson L, Barnes S, Lovelady C, Oduk Y, Williams RM, Jaimes EA, Heller DA, Saigusa T. Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice. Sci Rep. 2024 07 02; 14(1):15140.

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Kaeberlein TL, Green AS, Haddad G, Hudson J, Isman A, Nyquist A, Rosen BS, Suh Y, Zalzala S, Zhang X, Blagosklonny MV, An JY, Kaeberlein M. Evaluation of off-label rapamycin use to promote healthspan in 333 adults. Geroscience. 2023 10; 45(5):2757-2768.

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Niture S, Tricoli L, Qi Q, Gadi S, Hayes K, Kumar D. MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation. Tumour Biol. 2022; 44(1):107-127.

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Chakraborty S, Utter MB, Frias MA, Foster DA. Cancer cells with defective RB and CDKN2A are resistant to the apoptotic effects of rapamycin. Cancer Lett. 2021 12 01; 522:164-170.

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Hao Q, Wang P, Dutta P, Chung S, Li Q, Wang K, Li J, Cao W, Deng W, Geng Q, Schrode K, Shaheen M, Wu K, Zhu D, Chen QH, Chen G, Elshimali Y, Vadgama J, Wu Y. Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA. Cell Death Dis. 2020 12 11; 11(12):1052.

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Venugopal SV, Caggia S, Gambrell-Sanders D, Khan SA. Differential roles and activation of mammalian target of rapamycin complexes 1 and 2 during cell migration in prostate cancer cells. Prostate. 2020 04; 80(5):412-423.

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Yang X, Hei C, Liu P, Li PA. Prevention of post-ischemic seizure by rapamycin is associated with deactivation of mTOR and ERK1/2 pathways in hyperglycemic rats. Biochem Biophys Res Commun. 2019 11 26; 520(1):47-53.

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Tannir NM, Msaouel P, Ross JA, Devine CE, Chandramohan A, Gonzalez GMN, Wang X, Wang J, Corn PG, Lim ZD, Pruitt L, Karam JA, Wood CG, Zurita AJ. Temsirolimus versus Pazopanib (TemPa) in Patients with Advanced Clear-cell Renal Cell Carcinoma and Poor-risk Features: A Randomized Phase II Trial. Eur Urol Oncol. 2020 10; 3(5):687-694.

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Basar MA, Williamson K, Roy SD, Finger DS, Ables ET, Duttaroy A. Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila. Dev Biol. 2019 10 15; 454(2):97-107.

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