Ribosomal Protein S6 Kinases, 90-kDa
"Ribosomal Protein S6 Kinases, 90-kDa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
| Descriptor ID |
D038744
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.862.500 D12.644.360.600.500 D12.776.476.600.500
|
| Concept/Terms |
Ribosomal Protein S6 Kinases, 90-kDa- Ribosomal Protein S6 Kinases, 90-kDa
- Ribosomal Protein S6 Kinases, 90 kDa
- p90(rsk)
- MAP-Kinase-Activated Protein Kinase 1
- MAP Kinase Activated Protein Kinase 1
- MAPKAP Kinase-1
- MAPKAP Kinase 1
- MAP-Kinase-Activated Kinase 1
- MAP Kinase Activated Kinase 1
- Ribosomal Protein S6 Kinase, 90-kDa
- Ribosomal Protein S6 Kinase, 90 kDa
- p90 Ribosomal S6 Kinase
- MAPKAP-K1
- pp90(rsk)
- MAPKAPK1
|
Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases, 90-kDa".
Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases, 90-kDa".
This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in this website by year, and whether "Ribosomal Protein S6 Kinases, 90-kDa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2007 | 3 | 0 | 3 |
| 2008 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in Profiles.
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Shi GX, Yang WS, Jin L, Matter ML, Ramos JW. RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E190-E199.
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Sulzmaier FJ, Young-Robbins S, Jiang P, Geerts D, Prechtl AM, Matter ML, Kesari S, Ramos JW. RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics. Oncotarget. 2016 Nov 29; 7(48):79869-79884.
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Jung SK, Ha SJ, Jung CH, Kim YT, Lee HK, Kim MO, Lee MH, Mottamal M, Bode AM, Lee KW, Dong Z. Naringenin targets ERK2 and suppresses UVB-induced photoaging. J Cell Mol Med. 2016 May; 20(5):909-19.
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Morris BJ, Donlon TA, He Q, Grove JS, Masaki KH, Elliott A, Willcox DC, Allsopp R, Willcox BJ. Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry. J Gerontol A Biol Sci Med Sci. 2015 Feb; 70(2):133-42.
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Sulzmaier FJ, Ramos JW. RSK isoforms in cancer cell invasion and metastasis. Cancer Res. 2013 Oct 15; 73(20):6099-105.
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Gawecka JE, Young-Robbins SS, Sulzmaier FJ, Caliva MJ, Heikkil? MM, Matter ML, Ramos JW. RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J Biol Chem. 2012 Dec 21; 287(52):43424-37.
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Gawecka JE, Geerts D, Koster J, Caliva MJ, Sulzmaier FJ, Opoku-Ansah J, Wada RK, Bachmann AS, Ramos JW. PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. Int J Cancer. 2012 Oct 01; 131(7):1556-68.
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Todorovic C, Sherrin T, Pitts M, Hippel C, Rayner M, Spiess J. Suppression of the MEK/ERK signaling pathway reverses depression-like behaviors of CRF2-deficient mice. Neuropsychopharmacology. 2009 May; 34(6):1416-26.
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Thakur A, Sun Y, Bollig A, Wu J, Biliran H, Banerjee S, Sarkar FH, Liao DJ. Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells. Clin Cancer Res. 2008 Jul 15; 14(14):4427-36.
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Vaidyanathan H, Opoku-Ansah J, Pastorino S, Renganathan H, Matter ML, Ramos JW. ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19837-42.