MAP Kinase Kinase Kinase 2
"MAP Kinase Kinase Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 70-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 5. It is activated during the cellular response to GROWTH FACTORS, oxidative stress, and hyperosmotic conditions.
| Descriptor ID |
D048730
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.559.200 D12.644.360.400.200 D12.776.476.400.200
|
| Concept/Terms |
MAP Kinase Kinase Kinase 2- MAP Kinase Kinase Kinase 2
- MEKK-2 Protein Kinase
- MEKK 2 Protein Kinase
- Protein Kinase, MEKK-2
- MEKK2 Protein Kinase
- Protein Kinase, MEKK2
- MAP3K2 Protein Kinase
- Protein Kinase, MAP3K2
- MEKK2 Protein
- MEK Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinase 2".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinase 2" by people in this website by year, and whether "MAP Kinase Kinase Kinase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "MAP Kinase Kinase Kinase 2" by people in Profiles.
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Ahmad S, St Hilaire VR, Dandepally SR, Johnson GL, Williams AL, Scott JE. Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2). Biochem Biophys Res Commun. 2018 01 29; 496(1):205-211.
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Ahmad S, Johnson GL, Scott JE. Identification of ponatinib and other known kinase inhibitors with?potent MEKK2 inhibitory activity. Biochem Biophys Res Commun. 2015 Aug 07; 463(4):888-93.
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Ahmad S, Hughes MA, Johnson GL, Scott JE. Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors. J Biomol Screen. 2013 Apr; 18(4):388-99.