Drug Discovery

"Drug Discovery" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process of finding chemicals for potential therapeutic use.

Descriptor ID	D055808
MeSH Number(s)	E05.295 H01.158.703.007.675 H01.181.466.675
Concept/Terms	Drug Discovery Drug Discovery Discovery, Drug Drug Prospecting Drug Prospecting Prospecting, Drug

Below are MeSH descriptors whose meaning is more general than "Drug Discovery".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Drug Discovery [E05.295]
Natural Sciences [H]
Natural Science Disciplines [H01]
Biological Science Disciplines [H01.158]
Pharmacology [H01.158.703]
Chemistry, Pharmaceutical [H01.158.703.007]
Drug Discovery [H01.158.703.007.675]
Chemistry [H01.181]
Chemistry, Pharmaceutical [H01.181.466]
Drug Discovery [H01.181.466.675]

Below are MeSH descriptors whose meaning is related to "Drug Discovery".

Below are MeSH descriptors whose meaning is more specific than "Drug Discovery".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Drug Discovery" by people in this website by year, and whether "Drug Discovery" was a major or minor topic of these publications.

Bar chart showing 94 publications over 18 distinct years, with a maximum of 14 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2009	1	3	4
2010	2	1	3
2011	3	2	5
2012	1	4	5
2013	4	1	5
2014	3	4	7
2015	2	7	9
2016	3	5	8
2017	4	0	4
2018	6	8	14
2019	2	1	3
2020	3	3	6
2021	3	2	5
2022	0	2	2
2023	0	2	2
2024	1	4	5
2025	1	5	6

Below are the most recent publications written about "Drug Discovery" by people in Profiles.

Liu M, Wan S, Guo S, Liu J, Li W, Wang L, Li F, Zhang J, Liu X, Liu D, Yao X, Gao J, Ruan K, He W. Fragment-Based Discovery of a Small-Molecule RhoGDI2 Ligand, HR3119, that Inhibits Cancer Cell Migration. ACS Chem Biol. 2025 11 21; 20(11):2584-2592.

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Patra S, Namballa HK, Gudipally AR, Xie L, Xie L, Harding WW. Discovery of a selective a2C-AR scaffold from a molecular hybridization approach. Bioorg Med Chem. 2025 Dec 15; 131:118424.

View in: PubMed
Daniels MH, Castro J, Lee YT, Gotur D, Knockenhauer KE, Grigoriu S, Lockbaum GJ, Cheong JE, Lu C, Brennan D, Buker SM, Liu J, Yao S, Sparling BA, Sickmier EA, Ribich S, Blakemore SJ, Silver SJ, Boriack-Sjodin PA, Duncan KW, Copeland RA. Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9. J Med Chem. 2025 May 08; 68(9):9537-9554.

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Salinas Y, Chauhan SC, Bandyopadhyay D. Small-Molecule Mitotic Inhibitors as Anticancer Agents: Discovery, Classification, Mechanisms of Action, and Clinical Trials. Int J Mol Sci. 2025 Apr 01; 26(7).

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Saeger S, West-Jeppson K, Liao Y-R, Campuzano A, Yu J-J, Lopez-Ribot J, Hung C-Y. Discovery of novel antifungal drugs via screening repurposing libraries against Coccidioides posadasii spherule initials. mBio. 2025 May 14; 16(5):e0020525.

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Anaya YA, Bracho RP, Chauhan SC, Tripathi MK, Bandyopadhyay D. Small Molecule B-RAF Inhibitors as Anti-Cancer Therapeutics: Advances in Discovery, Development, and Mechanistic Insights. Int J Mol Sci. 2025 Mar 16; 26(6).

View in: PubMed
Nie Z, Bonnert R, Tsien J, Deng X, Higgs C, El Mazouni F, Zhang X, Li R, Ho N, Feher V, Paulsen J, Shackleford DM, Katneni K, Chen G, Ng ACF, McInerney M, Wang W, Saunders J, Collins D, Yan D, Li P, Campbell M, Patil R, Ghoshal A, Mondal P, Kundu A, Chittimalla R, Mahadeva M, Kokkonda S, White J, Das R, Mukherjee P, Angulo-Barturen I, Jim?nez-D?az MB, Malmstrom R, Lawrenz M, Rodriguez-Granillo A, Rathod PK, Tomchick DR, Palmer MJ, Laleu B, Qin T, Charman SA, Phillips MA. Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J Med Chem. 2025 01 09; 68(1):590-637.

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Dumas A, Goyal N, Mottamal M, Afosah DK, Al-Horani RA. Discovery of a new lead molecule to develop a novel class of human factor XIIa inhibitors. J Thromb Thrombolysis. 2024 Dec; 57(8):1308-1314.

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Peng X, Guo S, Zheng S, Hossain A, Zhang C, Mottamal M, Skripnikova E, Ma P, Martinez-Carter K, Zhang Q, Abedin F, Huckaba T, Wang G. Discovery of Oral Degraders of the ROS1 Fusion Protein with Potent Activity against Secondary Resistance Mutations. J Med Chem. 2024 Oct 24; 67(20):18098-18123.

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Dorogan M, Namballa HK, Harding WW. Natural Product-Inspired Dopamine Receptor Ligands. J Med Chem. 2024 08 08; 67(15):12463-12484.

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