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John Scott

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionNorth Carolina Central University
DepartmentBiomanufacturing Research Institute and Technology Enterprise
AddressBiomanufacturing Research Institute and Technology Enterprise (BRITE)
Durham NC 27707
Phone+19195307569
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    Collapse Research 
    Collapse research activities and funding
    SC2GM081129     (SCOTT, JOHN)Sep 25, 2007 - Aug 31, 2010
    NIH
    Discovery of a Selective Agent that Activates PON1 Enzymatic Activity
    Role: Principal Investigator
    SC2HL094340     (SCOTT, JOHN)Sep 25, 2007 - Aug 31, 2011
    NIH
    Discovery of a Selective Agent that Activates PON1 Enzymatic Activity
    Role: Principal Investigator
    R01CA161160     (SONDEK, JOHN E)Sep 1, 2012 - Jun 30, 2016
    NIH
    Small molecule inhibition of Rho GTPase activation to probe signaling cascades
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Navarro H, Scott JE, Smith GR, Ghiabi P, Gibson E, Loppnau P, Harding RJ, Hossain MA, Bose MR, Pearce KH, Merten EM, Willson TM, Brown PJ. Identification of Inhibitors of Chikungunya virus nsP2 ATPase. bioRxiv. 2025 Jan 14. PMID: 39677726.
      Citations:    
    2. Ahmad S, Wood KC, Scott JE. A high throughput proliferation and cytotoxicity assay for co-cultured isogenic cell lines. MethodsX. 2022; 9:101927. PMID: 36438856.
      Citations:    
    3. Kharabsheh HA, Scott JE. CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in?vitro. Biochem Biophys Res Commun. 2020 09 10; 530(1):136-141. PMID: 32828275.
      Citations: 5     Fields:    Translation:HumansCells
    4. Ahmad S, He Q, Williams KP, Scott JE. Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach. SLAS Discov. 2020 09; 25(8):923-938. PMID: 32441190.
      Citations: 8     Fields:    Translation:HumansAnimals
    5. Ahmad S, St Hilaire VR, Dandepally SR, Johnson GL, Williams AL, Scott JE. Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2). Biochem Biophys Res Commun. 2018 01 29; 496(1):205-211. PMID: 29309787.
      Citations: 3     Fields:    Translation:HumansCells
    6. Ahmad S, Johnson GL, Scott JE. Identification of ponatinib and other known kinase inhibitors with?potent MEKK2 inhibitory activity. Biochem Biophys Res Commun. 2015 Aug 07; 463(4):888-93. PMID: 26056008.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    7. Kong R, Liu T, Zhu X, Ahmad S, Williams AL, Phan AT, Zhao H, Scott JE, Yeh LA, Wong ST. Old drug new use--amoxapine and its metabolites as potent bacterial ?-glucuronidase inhibitors for alleviating cancer drug toxicity. Clin Cancer Res. 2014 Jul 01; 20(13):3521-30. PMID: 24780296.
      Citations: 44     Fields:    Translation:AnimalsCells
    8. Tarpley M, Abdissa TT, Johnson GL, Scott JE. Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines. Anticancer Res. 2014 Apr; 34(4):1629-35. PMID: 24692691.
      Citations: 5     Fields:    Translation:HumansCells
    9. Ahmad S, Hughes MA, Johnson GL, Scott JE. Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors. J Biomol Screen. 2013 Apr; 18(4):388-99. PMID: 23134735.
      Citations: 11     Fields:    Translation:HumansCells
    10. Ahmad S, Hughes MA, Yeh LA, Scott JE. Potential repurposing of known drugs as potent bacterial ?-glucuronidase inhibitors. J Biomol Screen. 2012 Aug; 17(7):957-65. PMID: 22535688.
      Citations: 15     Fields:    Translation:Cells
    11. Ahmad S, Hughes MA, Lane KT, Redinbo MR, Yeh LA, Scott JE. A High Throughput Assay for Discovery of Bacterial ?-Glucuronidase Inhibitors. Curr Chem Genomics. 2011; 5:13-20. PMID: 21643506.
      Citations:    
    12. Ahmad S, Scott JE. Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression. Biochem Biophys Res Commun. 2010 Jul 02; 397(3):441-6. PMID: 20510879.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    13. Ahmad S, Carter JJ, Scott JE. A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity. Anal Biochem. 2010 May 01; 400(1):1-9. PMID: 20096260.
      Citations: 7     Fields:    Translation:HumansCells
    14. Williams KP, Scott JE. Enzyme assay design for high-throughput screening. Methods Mol Biol. 2009; 565:107-26. PMID: 19551359.
      Citations: 14     Fields:    
    15. Graves TL, Scott JE. A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity. Curr Chem Genomics. 2008 Nov 26; 2:51-61. PMID: 20161844.
      Citations:    
    16. Graves TL, Zhang Y, Scott JE. A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases. Anal Biochem. 2008 Feb 15; 373(2):296-306. PMID: 18028865.
      Citations: 26     Fields:    
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