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Vernadeth Alarcon, PhD

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentAnatomy, Biochemistry & Physiology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa 651 Ilalo Street
651 Ilalo Street
Honolulu HI
Phone8086921417
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    Collapse Research 
    Collapse research activities and funding
    R03HD050475     (ALARCON, VERNADETH B)Jul 6, 2005 - Jun 30, 2008
    NIH
    Role of Par Genes in the Early Mouse Embryo
    Role: Principal Investigator
    R03HD088839     (ALARCON, VERNADETH B)Aug 1, 2017 - Jul 31, 2020
    NIH
    Regulation of trophectoderm development by mevalonate pathway
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Marikawa Y, Alarcon VB. An active metabolite of the anti-COVID-19 drug molnupiravir impairs mouse preimplantation embryos at clinically relevant concentrations. Reprod Toxicol. 2023 10; 121:108475. PMID: 37748715.
      Citations: 2     Fields:    Translation:Animals
    2. Alarcon VB, Marikawa Y. Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling. Reproduction. 2022 10 01; 164(4):R75-R86. PMID: 35900353.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    3. Marikawa Y, Alarcon VB. Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations. Reprod Toxicol. 2022 08; 111:135-147. PMID: 35605700.
      Citations: 4     Fields:    Translation:Animals
    4. Marikawa Y, Menor M, Deng Y, Alarcon VB. Regulation of endoplasmic reticulum stress and trophectoderm lineage specification by the mevalonate pathway in the mouse preimplantation embryo. Mol Hum Reprod. 2021 03 24; 27(4). PMID: 33677573.
      Citations: 3     Fields:    Translation:HumansAnimals
    5. Marikawa Y, Chen HR, Menor M, Deng Y, Alarcon VB. Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 01; 91:74-91. PMID: 31711903.
      Citations: 14     Fields:    Translation:HumansCells
    6. Marikawa Y, Alarcon VB. RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner. Mol Hum Reprod. 2019 02 01; 25(2):43-60. PMID: 30395288.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Alarcon VB, Marikawa Y. ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation. Adv Anat Embryol Cell Biol. 2018; 229:47-68. PMID: 29177764.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Alarcon VB, Marikawa Y. Statins inhibit blastocyst formation by preventing geranylgeranylation. Mol Hum Reprod. 2016 05; 22(5):350-63. PMID: 26908642.
      Citations: 14     Fields:    Translation:AnimalsCells
    9. Kono K, Tamashiro DA, Alarcon VB. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev Biol. 2014 Oct 01; 394(1):142-55. PMID: 24997360.
      Citations: 61     Fields:    Translation:AnimalsCells
    10. Laeno AM, Tamashiro DA, Alarcon VB. Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst. Biol Reprod. 2013 Nov; 89(5):122. PMID: 23946538.
      Citations: 23     Fields:    Translation:AnimalsCells
    11. Hirate Y, Hirahara S, Inoue K, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, Sasaki H. Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol. 2013 Jul 08; 23(13):1181-94. PMID: 23791731.
      Citations: 176     Fields:    Translation:AnimalsCells
    12. Ortega MA, Marh J, Alarcon VB, Ward WS. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Biol Reprod. 2012 Sep; 87(3):62. PMID: 22674395.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Tamashiro DA, Alarcon VB, Marikawa Y. Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell. Differentiation. 2012 Jun; 83(5):282-92. PMID: 22475651.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Marikawa Y, Alarcon VB. Creation of trophectoderm, the first epithelium, in mouse preimplantation development. Results Probl Cell Differ. 2012; 55:165-84. PMID: 22918806.
      Citations: 26     Fields:    Translation:Animals
    15. Gelber K, Tamura AN, Alarcon VB, Marikawa Y. A potential use of embryonic stem cell medium for the in vitro culture of preimplantation embryos. J Assist Reprod Genet. 2011 Aug; 28(8):659-68. PMID: 21617931.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Marikawa Y, Tamashiro DA, Fujita TC, Alarcon VB. Dual roles of Oct4 in the maintenance of mouse P19 embryonal carcinoma cells: as negative regulator of Wnt/?-catenin signaling and competence provider for Brachyury induction. Stem Cells Dev. 2011 Apr; 20(4):621-33. PMID: 21083502.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    17. Alarcon VB. Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo. Biol Reprod. 2010 Sep; 83(3):347-58. PMID: 20505164.
      Citations: 63     Fields:    Translation:AnimalsCells
    18. Alarc?n VB, Marikawa Y. Spatial alignment of the mouse blastocyst axis across the first cleavage plane is caused by mechanical constraint rather than developmental bias among blastomeres. Mol Reprod Dev. 2008 Jul; 75(7):1143-53. PMID: 18196554.
      Citations: 10     Fields:    Translation:AnimalsCells
    19. Fogelgren B, Kuroyama MC, McBratney-Owen B, Spence AA, Malahn LE, Anawati MK, Cabatbat C, Alarcon VB, Marikawa Y, Lozanoff S. Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice. Dev Dyn. 2008 Jul; 237(7):1767-79. PMID: 18570229.
      Citations: 23     Fields:    Translation:AnimalsCells
    20. Hiiragi T, Alarcon VB, Fujimori T, Louvet-Vallee S, Maleszewski M, Marikawa Y, Maro B, Solter D. Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005). Int J Dev Biol. 2006; 50(7):581-6; discussion 586-7. PMID: 16892171.
      Citations: 15     Fields:    Translation:AnimalsCells
    21. Alarc?n VB, Marikawa Y. Unbiased contribution of the first two blastomeres to mouse blastocyst development. Mol Reprod Dev. 2005 Nov; 72(3):354-61. PMID: 16078274.
      Citations: 17     Fields:    Translation:AnimalsCells
    22. Alarc?n VB, Marikawa Y. Molecular study of mouse peri-implantation development using the in vitro culture of aggregated inner cell mass. Mol Reprod Dev. 2004 Jan; 67(1):83-90. PMID: 14648878.
      Citations: 3     Fields:    Translation:HumansAnimals
    23. Alarc?n VB, Marikawa Y. Deviation of the blastocyst axis from the first cleavage plane does not affect the quality of mouse postimplantation development. Biol Reprod. 2003 Oct; 69(4):1208-12. PMID: 12773417.
      Citations: 19     Fields:    Translation:Animals
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