A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

Descriptor ID	D000690
MeSH Number(s)	C10.228.854.139 C10.574.562.250 C10.574.950.050 C10.668.467.250 C18.452.845.800.050
Concept/Terms	Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Sclerosis, Amyotrophic Lateral Charcot Disease Motor Neuron Disease, Amyotrophic Lateral Sclerosis Lou Gehrig Disease Lou Gehrig's Disease Lou-Gehrigs Disease Disease, Lou-Gehrigs ALS (Amyotrophic Lateral Sclerosis) Gehrig's Disease Gehrig Disease Gehrigs Disease Amyotrophic Lateral Sclerosis, Guam Form Amyotrophic Lateral Sclerosis, Guam Form Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam Guam Form of Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1 Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1 Guam Disease Disease, Guam Amyotrophic Lateral Sclerosis With Dementia Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis

Below are MeSH descriptors whose meaning is more general than "Amyotrophic Lateral Sclerosis".

Below are MeSH descriptors whose meaning is related to "Amyotrophic Lateral Sclerosis".

Below are MeSH descriptors whose meaning is more specific than "Amyotrophic Lateral Sclerosis".