NF-kappa B

"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

Descriptor ID	D016328
MeSH Number(s)	D12.776.260.600 D12.776.660.600 D12.776.930.600
Concept/Terms	NF-kappa B NF-kappa B kappa B Enhancer Binding Protein NF-kappaB NF kappaB Transcription Factor NF-kB Factor NF-kB, Transcription NF-kB, Transcription Factor Transcription Factor NF kB NF-kB NF kB Immunoglobulin Enhancer-Binding Protein Enhancer-Binding Protein, Immunoglobulin Immunoglobulin Enhancer Binding Protein Nuclear Factor kappa B Ig-EBP-1 Ig-EBP-1 Ig EBP 1

Below are MeSH descriptors whose meaning is more general than "NF-kappa B".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
NF-kappa B [D12.776.260.600]
Nuclear Proteins [D12.776.660]
NF-kappa B [D12.776.660.600]
Transcription Factors [D12.776.930]
NF-kappa B [D12.776.930.600]

Below are MeSH descriptors whose meaning is related to "NF-kappa B".

Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.

Bar chart showing 293 publications over 29 distinct years, with a maximum of 20 publications in 2004 and 2013 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	0	2	2
1999	1	0	1
2000	0	1	1
2001	1	1	2
2002	7	4	11
2003	8	5	13
2004	13	7	20
2005	10	6	16
2006	9	8	17
2007	5	4	9
2008	5	2	7
2009	5	6	11
2010	4	6	10
2011	8	4	12
2012	4	4	8
2013	11	9	20
2014	5	10	15
2015	9	11	20
2016	4	5	9
2017	4	13	17
2018	6	6	12
2019	4	8	12
2020	7	6	13
2021	2	2	4
2022	4	4	8
2023	5	7	12
2024	3	3	6
2025	2	2	4

Below are the most recent publications written about "NF-kappa B" by people in Profiles.

Du K, Zhang X, Qin Y, Ma H, Bing C, Deng S, Chen Y, Qin J, Chang S, Xiao S, Peng L, Xie X, Feng X, Fu X, Wei Y, Fan X, Ashktorab H, Smoot D, Jin Z, Peng Y. MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKa in gastric adenocarcinoma. Cell Death Dis. 2025 Sep 01; 16(1):667.

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Armina-Rodriguez A, Vald?s Fernandez BN, Ocasio-Malav? C, Cantres Rosario YM, Carrasquillo Carri?n K, Mel?ndez LM, Roche Lima A, Tosado Rodriguez EL, Espino AM. Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-?B, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages. Int J Mol Sci. 2025 Jul 18; 26(14).

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Ehrenberg PK, Geretz A, Volcic M, Izumi T, Yum LK, Waickman A, Shangguan S, Paquin-Proulx D, Creegan M, Bose M, Machmach K, McGraw A, Narahari A, Currier JR, Sacdalan C, Phanuphak N, Apps R, Corley M, Ndhlovu LC, Slike B, Krebs SJ, Anonworanich J, Tovanabutra S, Robb ML, Eller MA, Laird GM, Cyktor J, Daar ES, Crowell TA, Mellors JW, Vasan S, Michael NL, Kirchhoff F, Thomas R. Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts. Nat Commun. 2025 May 29; 16(1):4975.

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Abdou HM, Hamaad FA, Elmageed GMA, Katano H, Ghoneum MH. Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-?B and p38 MAPK Signaling Pathways. Oxid Med Cell Longev. 2025; 2025:3673280.

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Debarba LK, Jayarathne HSM, Stilgenbauer L, Dos Santos ALT, Koshko L, Scofield S, Sullivan R, Mandal A, Klueh U, Sadagurski M. Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-?B Signaling. Diabetes. 2024 Dec 01; 73(12):2065-2077.

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Yang H, Wang Z, Li L, Wang X, Wei X, Gou S, Ding Z, Cai Z, Ling Q, Hoffmann PR, He J, Liu F, Huang Z. Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-?B activation and enhancing glutathione peroxidase expression. J Nanobiotechnology. 2024 Oct 10; 22(1):613.

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Chuang TD, Ton N, Rysling S, Khorram O. In Vivo Effects of Bay 11-7082 on Fibroid Growth and Gene Expression: A Preclinical Study. Cells. 2024 06 24; 13(13).

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Ramar V, Guo S, Hudson B, Khedri A, Guo AA, Li J, Liu M. Interaction of NF-?B and FOSL1 drives glioma stemness. Cell Mol Life Sci. 2024 Jun 10; 81(1):255.

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da Silva RAG, Stocks CJ, Hu G, Kline KA, Chen J. Bosutinib Stimulates Macrophage Survival, Phagocytosis, and Intracellular Killing of Bacteria. ACS Infect Dis. 2024 05 10; 10(5):1725-1738.

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Rosario-Rodr?guez LJ, Cantres-Rosario YM, Carrasquillo-Carri?n K, Rodr?guez-De Jes?s AE, Cartagena-Isern LJ, Garc?a-Requena LA, Roche-Lima A, Mel?ndez LM. Quantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-?B Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected Macrophages. Int J Mol Sci. 2024 Mar 13; 25(6).

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