Proto-Oncogene Proteins c-akt

"Proto-Oncogene Proteins c-akt" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

Descriptor ID	D051057
MeSH Number(s)	D08.811.913.696.620.682.700.755 D12.776.476.565 D12.776.624.664.700.168
Concept/Terms	Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-akt Proto Oncogene Proteins c akt c-akt, Proto-Oncogene Proteins Protein Kinase B Proto-Oncogene Protein RAC Proto Oncogene Protein RAC RAC, Proto-Oncogene Protein Proto-Oncogene Protein Akt Akt, Proto-Oncogene Protein Proto Oncogene Protein Akt Rac Protein Kinase akt Proto-Oncogene Protein Protein, akt Proto-Oncogene Proto-Oncogene Protein, akt akt Proto Oncogene Protein RAC-PK Protein RAC PK Protein Related to A and C-Protein Related to A and C Protein c-akt Proto-Oncogene Protein Protein, c-akt Proto-Oncogene Proto-Oncogene Protein, c-akt c akt Proto Oncogene Protein c-akt Protein Protein-Serine-Threonine Kinase (Rac) Proto-Oncogene Proteins c-akt1 Proto-Oncogene Proteins c-akt1 Proteins c-akt1, Proto-Oncogene Proto Oncogene Proteins c akt1 c-akt1, Proto-Oncogene Proteins AKT1 Protein Kinase Rac-PK alpha Protein Rac PK alpha Protein alpha Protein, Rac-PK Protein Kinase B alpha Akt-alpha Protein Akt alpha Protein Proto-Oncogene Proteins c-akt2 Proto-Oncogene Proteins c-akt2 Proteins c-akt2, Proto-Oncogene Proto Oncogene Proteins c akt2 c-akt2, Proto-Oncogene Proteins Protein Kinase B beta Rac-PK beta Protein Rac PK beta Protein AKT2 Protein Kinase Akt-beta Protein Akt beta Protein Proto-Oncogene Proteins c-akt3 Proto-Oncogene Proteins c-akt3 Proteins c-akt3, Proto-Oncogene Proto Oncogene Proteins c akt3 c-akt3, Proto-Oncogene Proteins Akt-gamma Protein Akt gamma Protein AKT3 Protein Kinase Protein Kinase B gamma

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-akt".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Proto-Oncogene Proteins c-akt [D12.776.476.565]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-akt".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-akt".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins c-akt" by people in this website by year, and whether "Proto-Oncogene Proteins c-akt" was a major or minor topic of these publications.

Bar chart showing 207 publications over 25 distinct years, with a maximum of 18 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2001	0	4	4
2002	0	7	7
2003	0	9	9
2004	0	4	4
2005	2	10	12
2006	3	7	10
2007	10	4	14
2008	5	8	13
2009	3	6	9
2010	1	8	9
2011	5	13	18
2012	5	6	11
2013	7	5	12
2014	4	7	11
2015	3	8	11
2016	1	5	6
2017	2	8	10
2018	2	5	7
2019	3	3	6
2020	1	3	4
2021	2	2	4
2022	0	4	4
2023	2	5	7
2024	3	1	4

Below are the most recent publications written about "Proto-Oncogene Proteins c-akt" by people in Profiles.

M?rquez-Garb?n DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, Wadehra M, McCloskey SA, Pietras RJ. Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models. Nutrients. 2024 Jul 22; 16(14).

View in: PubMed
Newairy AA, Hamaad FA, Wahby MM, Ghoneum M, Abdou HM. Neurotherapeutic effects of quercetin-loaded nanoparticles and Biochanin-A extracted from Trifolium alexandrinum on PI3K/Akt/GSK-3? signaling in the cerebral cortex of male diabetic rats. PLoS One. 2024; 19(4):e0301355.

View in: PubMed
Sampath C, Chukkapalli SS, Raju AV, Alluri LSC, Srisai D, Gangula PR. Cinnamaldehyde Protects against P. gingivalis Induced Intestinal Epithelial Barrier Dysfunction in IEC-6 Cells via the PI3K/Akt-Mediated NO/Nrf2 Signaling Pathway. Int J Mol Sci. 2024 Apr 26; 25(9).

View in: PubMed
Brown LK, Kanagasabai T, Li G, Celada SI, Rumph JT, Adunyah SE, Stewart LV, Chen Z. Co-targeting SKP2 and KDM5B inhibits prostate cancer progression by abrogating AKT signaling with induction of senescence and apoptosis. Prostate. 2024 Jun; 84(9):877-887.

View in: PubMed
Ahmed SA, Mendonca P, Messeha SS, Oriaku ET, Soliman KFA. The Anticancer Effects of Marine Carotenoid Fucoxanthin through Phosphatidylinositol 3-Kinase (PI3K)-AKT Signaling on Triple-Negative Breast Cancer Cells. Molecules. 2023 Dec 21; 29(1).

View in: PubMed
Yu J, Li J, Matei N, Wang W, Tang L, Pang J, Li X, Fang L, Tang J, Zhang JH, Yan M. Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats. Exp Neurol. 2024 Mar; 373:114656.

View in: PubMed
Messeha SS, Noel S, Zarmouh NO, Womble T, Latinwo LM, Soliman KFA. Involvement of AKT/PI3K Pathway in Sanguinarine's Induced Apoptosis and Cell Cycle Arrest in Triple-negative Breast Cancer Cells. Cancer Genomics Proteomics. 2023 Jul-Aug; 20(4):323-342.

View in: PubMed
Banerjee S, Xu W, Doctor A, Driss A, Nezhat C, Sidell N, Taylor RN, Thompson WE, Chowdhury I. TNFa-Induced Altered miRNA Expression Links to NF-?B Signaling Pathway in Endometriosis. Inflammation. 2023 Dec; 46(6):2055-2070.

View in: PubMed
Singla B, Aithbathula RV, Pervaiz N, Kathuria I, Swanson M, Ekuban FA, Ahn W, Park F, Gyamfi M, Cherian-Shaw M, Singh UP, Kumar S. CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis. Arterioscler Thromb Vasc Biol. 2023 07; 43(7):1234-1250.

View in: PubMed
Rashid R, Tripathi R, Singh A, Sarkar S, Kawale A, Bader GN, Gupta S, Gupta RK, Jha RK. Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole-induced polycystic ovary syndrome in the Sprague Dawley rats. Phytother Res. 2023 Sep; 37(9):4018-4041.

View in: PubMed

People

Explore

Similar Concepts

Top Journals