Blood-Brain Barrier

"Blood-Brain Barrier" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.

Descriptor ID	D001812
MeSH Number(s)	A07.035 A08.186.211.035
Concept/Terms	Blood-Brain Barrier Blood-Brain Barrier Barrier, Blood-Brain Barriers, Blood-Brain Blood Brain Barrier Blood-Brain Barriers Hemato-Encephalic Barrier Barrier, Hemato-Encephalic Barriers, Hemato-Encephalic Hemato Encephalic Barrier Hemato-Encephalic Barriers Brain-Blood Barrier Barrier, Brain-Blood Barriers, Brain-Blood Brain Blood Barrier Brain-Blood Barriers

Below are MeSH descriptors whose meaning is more general than "Blood-Brain Barrier".

Anatomy [A]
Cardiovascular System [A07]
Blood-Brain Barrier [A07.035]
Nervous System [A08]
Central Nervous System [A08.186]
Brain [A08.186.211]
Blood-Brain Barrier [A08.186.211.035]

Below are MeSH descriptors whose meaning is related to "Blood-Brain Barrier".

Below are MeSH descriptors whose meaning is more specific than "Blood-Brain Barrier".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Blood-Brain Barrier" by people in this website by year, and whether "Blood-Brain Barrier" was a major or minor topic of these publications.

Bar chart showing 132 publications over 26 distinct years, with a maximum of 9 publications in 2018 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	1	2
2000	0	1	1
2002	1	2	3
2003	3	2	5
2004	0	2	2
2005	3	5	8
2006	1	3	4
2007	2	2	4
2008	1	4	5
2009	3	3	6
2010	3	5	8
2011	3	5	8
2012	2	3	5
2013	3	3	6
2014	2	4	6
2015	1	2	3
2016	5	2	7
2017	0	3	3
2018	3	6	9
2019	7	2	9
2020	4	4	8
2021	5	2	7
2022	1	2	3
2023	1	2	3
2024	5	0	5
2025	0	2	2

Below are the most recent publications written about "Blood-Brain Barrier" by people in Profiles.

Kucheryavykh L, Ortiz Rivera J, Ermolinsky B, Tsytsarev V, Cary L, Alves J, Reyes A, de la Cruz-Rivera N, Rosa Gonzalez K, Narvaez Irizarry F, Porter TR, Inyushin M. Targeting Gliomas with Beta-Amyloid-Specific Dyes: A Novel Approach for In Vivo Staining and Potential Therapeutic Applications. Int J Mol Sci. 2025 Oct 28; 26(21).

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Bogadi S, Bhaskaran M, Ravichandran V, Nesamony J, Chelliah S, Kuppusamy G, Prakash GM, Karri VVSR, Mallick S, Farahim F, Ali T, Babu DR, Subramaniyan V. Functionalized Nanoparticles: A Promising Approach for Effective Management of Alzheimer's Disease. Mol Neurobiol. 2025 Aug; 62(8):10915-10934.

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Wang Z, Veerareddy V, Tang X, Thompson KJ, Krishnan S, Kalari KR, Kandimalla KK. QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid-Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium. CPT Pharmacometrics Syst Pharmacol. 2025 Mar; 14(3):561-571.

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Salian VS, Tang X, Thompson KJ, Curan GL, Lowe VJ, Li L, Kalari KR, Kandimalla KK. Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease. J Pharmacol Exp Ther. 2024 Nov 19; 391(3):430-440.

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Wang Z, Zhong R, Curran GL, Min P, Lowe VJ, Li L, Kandimalla KK. High-Density Lipoprotein Mimetic Peptide 4F Reduces Toxic Amyloid-Beta Exposure to the Blood-Brain Barrier Endothelium in Alzheimer's Disease Transgenic Mice. Mol Pharm. 2024 Nov 04; 21(11):5661-5671.

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Zhou AL, Swaminathan SK, Salian VS, Wang L, Curran GL, Min HK, Lowe VJ, Kandimalla KK. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier. Mol Pharm. 2024 May 06; 21(5):2176-2186.

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Yuan Y, He Q, Yang X, Flores JJ, Huang L, Luo X, Zhang X, Zhang Z, Li R, Gu L, Dong S, Zhu S, Yi K, Han M, Wu L, Zhou Y, Zhang JH, Xie Z, Tang J. Mitochondrial ferritin upregulation reduced oxidative stress and blood-brain-barrier disruption by maintaining cellular iron homeostasis in a neonatal rat model of germinal matrix hemorrhage. Exp Neurol. 2024 Apr; 374:114703.

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Abbasloo E, Khaksari M, Sanjari M, Kobeissy F, Thomas TC. Carvacrol decreases blood-brain barrier permeability post-diffuse traumatic brain injury in rats. Sci Rep. 2023 09 04; 13(1):14546.

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Wang Z, Sharda N, Omtri RS, Li L, Kandimalla KK. Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood-Brain Barrier Endothelium. Mol Pharmacol. 2023 11; 104(5):203-213.

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Toropova AP, Toropov AA, Roncaglioni A, Benfenati E, Leszczynska D, Leszczynski J. The validation of predictive potential via the system of self-consistent models: the simulation of blood-brain barrier permeation of organic compounds. J Mol Model. 2023 Jun 29; 29(7):218.

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