Retinoblastoma Protein

"Retinoblastoma Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.

Descriptor ID	D016160
MeSH Number(s)	D12.776.260.704 D12.776.624.776.745 D12.776.660.807 D12.776.744.770
Concept/Terms	Retinoblastoma Protein Retinoblastoma Protein Rb1 Gene Product Rb Gene Product Rb Protein p105-Rb Protein p105-Rb Protein p105 Rb Protein Retinoblastoma Nuclear Phosphoprotein p105-Rb Retinoblastoma Nuclear Phosphoprotein p105 Rb

Below are MeSH descriptors whose meaning is more general than "Retinoblastoma Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Retinoblastoma Protein [D12.776.260.704]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Retinoblastoma Protein [D12.776.624.776.745]
Nuclear Proteins [D12.776.660]
Retinoblastoma Protein [D12.776.660.807]
Phosphoproteins [D12.776.744]
Retinoblastoma Protein [D12.776.744.770]

Below are MeSH descriptors whose meaning is related to "Retinoblastoma Protein".

Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Retinoblastoma Protein" by people in this website by year, and whether "Retinoblastoma Protein" was a major or minor topic of these publications.

Bar chart showing 22 publications over 14 distinct years, with a maximum of 4 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	1	0	1
2003	2	2	4
2004	1	0	1
2006	0	1	1
2007	0	2	2
2010	1	1	2
2011	1	0	1
2012	0	1	1
2013	3	0	3
2015	2	0	2
2016	0	1	1
2017	0	1	1
2021	1	0	1

Below are the most recent publications written about "Retinoblastoma Protein" by people in Profiles.

Chakraborty S, Utter MB, Frias MA, Foster DA. Cancer cells with defective RB and CDKN2A are resistant to the apoptotic effects of rapamycin. Cancer Lett. 2021 12 01; 522:164-170.

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Kundu N, Brekman A, Kim JY, Xiao G, Gao C, Bargonetti J. Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway. Oncotarget. 2017 Jul 18; 8(29):47916-47930.

View in: PubMed
Mir H, Kapur N, Singh R, Sonpavde G, Lillard JW, Singh S. Andrographolide inhibits prostate cancer by targeting cell cycle regulators, CXCR3 and CXCR7 chemokine receptors. Cell Cycle. 2016; 15(6):819-26.

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Sosa-Garc?a B, V?zquez-Rivera V, Gonz?lez-Flores JN, Engel BE, Cress WD, Santiago-Cardona PG. The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts. PLoS One. 2015; 10(11):e0142406.

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Chatterjee A, Mukhopadhyay S, Tung K, Patel D, Foster DA. Rapamycin-induced G1 cell cycle arrest employs both TGF-? and Rb pathways. Cancer Lett. 2015 May 01; 360(2):134-40.

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Tan HL, Sood A, Rahimi HA, Wang W, Gupta N, Hicks J, Mosier S, Gocke CD, Epstein JI, Netto GJ, Liu W, Isaacs WB, De Marzo AM, Lotan TL. Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma. Clin Cancer Res. 2014 Feb 15; 20(4):890-903.

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Engel BE, Welsh E, Emmons MF, Santiago-Cardona PG, Cress WD. Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors. Cell Death Dis. 2013 Nov 28; 4:e938.

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Ma KL, Liu J, Wang CX, Ni J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC. Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation. Cardiovasc Res. 2013 Dec 01; 100(3):450-60.

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Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature. 2012 Jan 11; 481(7381):329-34.

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Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. J Neuropathol Exp Neurol. 2011 Jul; 70(7):578-87.

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