p21-Activated Kinases

"p21-Activated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.

Descriptor ID	D054462
MeSH Number(s)	D08.811.913.696.620.682.700.596 D12.644.360.552 D12.776.476.548
Concept/Terms	p21-Activated Kinases p21-Activated Kinases Kinases, p21-Activated p21 Activated Kinases PAK Kinases Kinases, PAK p21-Activated Kinase 2 p21-Activated Kinase 2 p21 Activated Kinase 2 p65(PAK) p65PAK Protein PAK-2 Kinase PAK 2 Kinase PAK2 Kinase PAK65 gamma-PAK gamma PAK p21-Activated Kinase 1 p21-Activated Kinase 1 p21 Activated Kinase 1 Serine-Threonine-Protein Kinase PAK 1 Serine Threonine Protein Kinase PAK 1 alpha p21-Activated Kinase alpha p21 Activated Kinase alpha-PAK PAK1 Kinase PAK-1 Kinase PAK 1 Kinase p21-Activated Kinase 3 p21-Activated Kinase 3 p21 Activated Kinase 3 Oligophrenin-3 Oligophrenin 3 Serine-Threonine-Protein Kinase PAK 3 Serine Threonine Protein Kinase PAK 3 PAK3 Kinase beta p21-Activated Kinase beta p21 Activated Kinase p21-Activated Kinase, beta beta-PAK

Below are MeSH descriptors whose meaning is more general than "p21-Activated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
p21-Activated Kinases [D08.811.913.696.620.682.700.596]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
p21-Activated Kinases [D12.644.360.552]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
p21-Activated Kinases [D12.776.476.548]

Below are MeSH descriptors whose meaning is related to "p21-Activated Kinases".

Below are MeSH descriptors whose meaning is more specific than "p21-Activated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "p21-Activated Kinases" by people in this website by year, and whether "p21-Activated Kinases" was a major or minor topic of these publications.

Bar chart showing 11 publications over 7 distinct years, with a maximum of 4 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	2	2
2005	0	1	1
2008	1	0	1
2010	0	1	1
2011	0	1	1
2013	2	2	4
2015	1	0	1

Below are the most recent publications written about "p21-Activated Kinases" by people in Profiles.

Sosa-Garc?a B, V?zquez-Rivera V, Gonz?lez-Flores JN, Engel BE, Cress WD, Santiago-Cardona PG. The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts. PLoS One. 2015; 10(11):e0142406.

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Garcia M, Ray S, Brown I, Irom J, Brazill D. PakD, a putative p21-activated protein kinase in Dictyostelium discoideum, regulates actin. Eukaryot Cell. 2014 Jan; 13(1):119-26.

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Martin H, Mali RS, Ma P, Chatterjee A, Ramdas B, Sims E, Munugalavadla V, Ghosh J, Mattingly RR, Visconte V, Tiu RV, Vlaar CP, Dharmawardhane S, Kapur R. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. J Clin Invest. 2013 Oct; 123(10):4449-63.

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Dharmawardhane S, Hernandez E, Vlaar C. Development of EHop-016: a small molecule inhibitor of Rac. Enzymes. 2013; 33 Pt A:117-46.

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Castillo-Pichardo L, Cubano LA, Dharmawardhane S. Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice. BMC Complement Altern Med. 2013 Jan 08; 13:6.

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Fortson WS, Kayarthodi S, Fujimura Y, Xu H, Matthews R, Grizzle WE, Rao VN, Bhat GK, Reddy ES. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J Oncol. 2011 Jul; 39(1):111-9.

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Sosa-Garc?a B, Gunduz V, V?zquez-Rivera V, Cress WD, Wright G, Bian H, Hinds PW, Santiago-Cardona PG. A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS One. 2010 Nov 11; 5(11):e13954.

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Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol. 2008 Apr; 15(4):322-31.

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Woolfolk EA, Eguchi S, Ohtsu H, Nakashima H, Ueno H, Gerthoffer WT, Motley ED. Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1286-94.

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Johnson K, D'Mello SR. p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival. J Neurosci Res. 2005 Mar 15; 79(6):809-15.

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