rac GTP-Binding Proteins

"rac GTP-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 3.6.1.47.

Descriptor ID	D020744
MeSH Number(s)	D08.811.277.040.330.300.400.700.100 D12.644.360.525.700.100 D12.776.157.325.515.700.100 D12.776.476.525.700.100
Concept/Terms	rac GTP-Binding Proteins rac GTP-Binding Proteins GTP-Binding Proteins, rac rac GTP Binding Proteins rac Proteins rac G Protein G Protein, rac

Below are MeSH descriptors whose meaning is more general than "rac GTP-Binding Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Monomeric GTP-Binding Proteins [D08.811.277.040.330.300.400]
rho GTP-Binding Proteins [D08.811.277.040.330.300.400.700]
rac GTP-Binding Proteins [D08.811.277.040.330.300.400.700.100]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Monomeric GTP-Binding Proteins [D12.644.360.525]
rho GTP-Binding Proteins [D12.644.360.525.700]
rac GTP-Binding Proteins [D12.644.360.525.700.100]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Monomeric GTP-Binding Proteins [D12.776.157.325.515]
rho GTP-Binding Proteins [D12.776.157.325.515.700]
rac GTP-Binding Proteins [D12.776.157.325.515.700.100]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Monomeric GTP-Binding Proteins [D12.776.476.525]
rho GTP-Binding Proteins [D12.776.476.525.700]
rac GTP-Binding Proteins [D12.776.476.525.700.100]

Below are MeSH descriptors whose meaning is related to "rac GTP-Binding Proteins".

Below are MeSH descriptors whose meaning is more specific than "rac GTP-Binding Proteins".

rac GTP-Binding Proteins
rac1 GTP-Binding Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "rac GTP-Binding Proteins" by people in this website by year, and whether "rac GTP-Binding Proteins" was a major or minor topic of these publications.

Bar chart showing 14 publications over 11 distinct years, with a maximum of 3 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	2	1	3
2007	1	0	1
2010	0	1	1
2012	0	1	1
2013	2	0	2
2015	1	0	1
2016	1	0	1
2018	1	0	1
2021	1	0	1
2022	1	0	1

Below are the most recent publications written about "rac GTP-Binding Proteins" by people in Profiles.

Medina JI, Cruz-Collazo A, Del Mar Maldonado M, Gascot TM, Borrero-Garcia LD, Cooke M, Kazanietz MG, O'Farril EH, Vlaar CP, Dharmawardhane S. Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42. Cancer Res Commun. 2022 12; 2(12):1711-1726.

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Borrero-Garc?a LD, Del Mar Maldonado M, Medina-Vel?zquez J, Troche-Torres AL, Velazquez L, Grafals-Ruiz N, Dharmawardhane S. Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer. BMC Cancer. 2021 Jun 01; 21(1):652.

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Maldonado MDM, Dharmawardhane S. Targeting Rac and Cdc42 GTPases in Cancer. Cancer Res. 2018 06 15; 78(12):3101-3111.

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Ubba V, Soni UK, Chadchan S, Maurya VK, Kumar V, Maurya R, Chaturvedi H, Singh R, Dwivedi A, Jha RK. RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model. Reprod Sci. 2017 05; 24(5):738-752.

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Humphries-Bickley T, Castillo-Pichardo L, Corujo-Carro F, Duconge J, Hernandez-O'Farrill E, Vlaar C, Rodriguez-Orengo JF, Cubano L, Dharmawardhane S. Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 15; 981-982:19-26.

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Martin H, Mali RS, Ma P, Chatterjee A, Ramdas B, Sims E, Munugalavadla V, Ghosh J, Mattingly RR, Visconte V, Tiu RV, Vlaar CP, Dharmawardhane S, Kapur R. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. J Clin Invest. 2013 Oct; 123(10):4449-63.

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Dharmawardhane S, Hernandez E, Vlaar C. Development of EHop-016: a small molecule inhibitor of Rac. Enzymes. 2013; 33 Pt A:117-46.

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Lee GL, Chang YW, Wu JY, Wu ML, Wu KK, Yet SF, Kuo CC. TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2751-60.

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Sosa-Garc?a B, Gunduz V, V?zquez-Rivera V, Cress WD, Wright G, Bian H, Hinds PW, Santiago-Cardona PG. A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS One. 2010 Nov 11; 5(11):e13954.

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Azios NG, Krishnamoorthy L, Harris M, Cubano LA, Cammer M, Dharmawardhane SF. Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. Neoplasia. 2007 Feb; 9(2):147-58.

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