cdc42 GTP-Binding Protein

"cdc42 GTP-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A member of the Rho family of MONOMERIC GTP-BINDING PROTEINS. It is associated with a diverse array of cellular functions including cytoskeletal changes, filopodia formation and transport through the GOLGI APPARATUS. This enzyme was formerly listed as EC 3.6.1.47.

Descriptor ID	D020764
MeSH Number(s)	D08.811.277.040.330.300.400.700.050 D12.644.360.525.700.050 D12.776.157.325.515.700.050 D12.776.476.525.700.050
Concept/Terms	cdc42 GTP-Binding Protein cdc42 GTP-Binding Protein GTP-Binding Protein, cdc42 cdc42 GTP Binding Protein p21 cdc42 cdc42, p21 cdc42 Protein G25K Protein G25K GTP-Binding Protein, Placental Isoform G25K GTP-Binding Protein, Placental Isoform G25K GTP Binding Protein, Placental Isoform G25P GTP-Binding Protein G25P GTP Binding Protein GTP-Binding Protein, G25P

Below are MeSH descriptors whose meaning is more general than "cdc42 GTP-Binding Protein".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Monomeric GTP-Binding Proteins [D08.811.277.040.330.300.400]
rho GTP-Binding Proteins [D08.811.277.040.330.300.400.700]
cdc42 GTP-Binding Protein [D08.811.277.040.330.300.400.700.050]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Monomeric GTP-Binding Proteins [D12.644.360.525]
rho GTP-Binding Proteins [D12.644.360.525.700]
cdc42 GTP-Binding Protein [D12.644.360.525.700.050]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Monomeric GTP-Binding Proteins [D12.776.157.325.515]
rho GTP-Binding Proteins [D12.776.157.325.515.700]
cdc42 GTP-Binding Protein [D12.776.157.325.515.700.050]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Monomeric GTP-Binding Proteins [D12.776.476.525]
rho GTP-Binding Proteins [D12.776.476.525.700]
cdc42 GTP-Binding Protein [D12.776.476.525.700.050]

Below are MeSH descriptors whose meaning is related to "cdc42 GTP-Binding Protein".

Below are MeSH descriptors whose meaning is more specific than "cdc42 GTP-Binding Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "cdc42 GTP-Binding Protein" by people in this website by year, and whether "cdc42 GTP-Binding Protein" was a major or minor topic of these publications.

Bar chart showing 15 publications over 12 distinct years, with a maximum of 2 publications in 2005 and 2017 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	0	1	1
2003	1	0	1
2004	0	1	1
2005	1	1	2
2006	1	0	1
2007	1	0	1
2011	1	0	1
2017	1	1	2
2018	2	0	2
2021	1	0	1
2022	0	1	1

Below are the most recent publications written about "cdc42 GTP-Binding Protein" by people in Profiles.

Gregory MD, Ofosu-Asante K, Lazarte JMS, Puente PE, Tawfeeq N, Belony N, Huang Y, Offringa IA, Lamango NS. Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis. PLoS One. 2024; 19(10):e0312563.

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Wei W, Zheng B, Zheng S, Wu D, Chu Y, Zhang S, Wang D, Ma X, Liu X, Yao X, Fu C. The Cdc42 GAP Rga6 promotes monopolar outgrowth of spores. J Cell Biol. 2023 01 02; 222(1).

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Cruz-Collazo A, Ruiz-Calderon JF, Picon H, Borrero-Garcia LD, Lopez I, Castillo-Pichardo L, Del Mar Maldonado M, Duconge J, Medina JI, Bayro MJ, Hern?ndez-O'Farrill E, Vlaar CP, Dharmawardhane S. Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer. Mol Cancer Ther. 2021 12; 20(12):2420-2432.

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Rivera-Robles MJ, Medina-Vel?zquez J, Asencio-Torres GM, Gonz?lez-Crespo S, Rymond BC, Rodr?guez-Medina J, Dharmawardhane S. Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae. Small GTPases. 2020 11; 11(6):430-440.

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Maldonado MDM, Dharmawardhane S. Targeting Rac and Cdc42 GTPases in Cancer. Cancer Res. 2018 06 15; 78(12):3101-3111.

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Ntantie E, Fletcher J, Amissah F, Salako OO, Nkembo AT, Poku RA, Ikpatt FO, Lamango NS. Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer. Oncotarget. 2017 May 09; 8(19):31726-31744.

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Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017 05; 16(5):805-818.

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Zuo X, Fogelgren B, Lipschutz JH. The small GTPase Cdc42 is necessary for primary ciliogenesis in renal tubular epithelial cells. J Biol Chem. 2011 Jun 24; 286(25):22469-77.

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Azios NG, Krishnamoorthy L, Harris M, Cubano LA, Cammer M, Dharmawardhane SF. Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. Neoplasia. 2007 Feb; 9(2):147-58.

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Xue Y, Bi F, Zhang X, Zhang S, Pan Y, Liu N, Shi Y, Yao X, Zheng Y, Fan D. Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation. Int J Cancer. 2006 Jun 15; 118(12):2965-72.

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