I-kappa B Kinase

"I-kappa B Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

Descriptor ID	D051550
MeSH Number(s)	D08.811.913.696.620.682.700.494 D12.644.360.361 D12.776.476.378
Concept/Terms	I-kappa B Kinase I-kappa B Kinase B Kinase, I-kappa Kinase, I-kappa B NK-kappa B-Activating Kinase NAK NK kappa B Activating Kinase NAK IkappaB Kinase Kinase, IkappaB I kappa B Kinase IkappaB Kinase gamma IkappaB Kinase gamma IKK gamma NF-kappaB Essential Modifier Essential Modifier, NF-kappaB NF kappaB Essential Modifier IkappaB Kinase epsilon IkappaB Kinase epsilon Kinase epsilon, IkappaB IKK epsilon IKKepsilon IkappaB Kinase alpha IkappaB Kinase alpha Kinase alpha, IkappaB IKK 1 Kinase IKK alpha Conserved Helix-Loop-Helix Ubiquitous Kinase Conserved Helix Loop Helix Ubiquitous Kinase CHUK Kinase I Kappa B alpha-Associated Protein Kinase I Kappa B alpha Associated Protein Kinase IkappaBalpha Kinase IkappaB Kinase beta IkappaB Kinase beta Kinase beta, IkappaB IKK beta IKBKB IKK 2 Kinase

Below are MeSH descriptors whose meaning is more general than "I-kappa B Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
I-kappa B Kinase [D08.811.913.696.620.682.700.494]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
I-kappa B Kinase [D12.644.360.361]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
I-kappa B Kinase [D12.776.476.378]

Below are MeSH descriptors whose meaning is related to "I-kappa B Kinase".

Below are MeSH descriptors whose meaning is more specific than "I-kappa B Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "I-kappa B Kinase" by people in this website by year, and whether "I-kappa B Kinase" was a major or minor topic of these publications.

Bar chart showing 43 publications over 20 distinct years, with a maximum of 4 publications in 2005 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	3	3
2003	0	2	2
2004	0	3	3
2005	2	2	4
2006	2	1	3
2008	1	0	1
2011	1	1	2
2012	1	0	1
2013	2	1	3
2014	3	1	4
2016	0	1	1
2017	1	0	1
2018	2	0	2
2019	1	0	1
2020	1	0	1
2021	2	0	2
2022	1	2	3
2023	0	1	1
2024	2	1	3
2025	2	0	2

Below are the most recent publications written about "I-kappa B Kinase" by people in Profiles.

Du K, Zhang X, Qin Y, Ma H, Bing C, Deng S, Chen Y, Qin J, Chang S, Xiao S, Peng L, Xie X, Feng X, Fu X, Wei Y, Fan X, Ashktorab H, Smoot D, Jin Z, Peng Y. MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKa in gastric adenocarcinoma. Cell Death Dis. 2025 Sep 01; 16(1):667.

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Borar P, Biswas T, Chaudhuri A, Rao PT, Raychaudhuri S, Huxford T, Chakrabarti S, Ghosh G, Polley S. Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate I?Ba through a phosphoenzyme intermediate. Elife. 2025 Jun 30; 13.

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Debarba LK, Jayarathne HSM, Stilgenbauer L, Dos Santos ALT, Koshko L, Scofield S, Sullivan R, Mandal A, Klueh U, Sadagurski M. Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-?B Signaling. Diabetes. 2024 Dec 01; 73(12):2065-2077.

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Suryajaya W, Biswas T, Shahabi S, Mealka M, Huxford T, Ghosh G. HDX-MS Analysis of Catalytic Activation of IKK2 in the I?B Kinase Complex. Biochemistry. 2024 09 17; 63(18):2323-2334.

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Kilich G, Patel S, Hassey K, Weinberger T, Sullivan KE. Pitfalls of genetic testing in a patient with IKBKG deficiency. Ann Allergy Asthma Immunol. 2024 Oct; 133(4):481-483.

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Abbasi M, Mahboubi-Rabbani M, Kashfi K, Sadeghi-Aliabadi H. Prediction of dual NF-?B/I?B inhibitors using an integrative in-silico approaches. J Biomol Struct Dyn. 2023; 41(23):14164-14178.

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Messeha SS, Zarmouh NO, Antonie L, Soliman KFA. Sanguinarine Inhibition of TNF-a-Induced CCL2, IKBKE/NF-?B/ERK1/2 Signaling Pathway, and Cell Migration in Human Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2022 Jul 28; 23(15).

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Rana S, Kour S, Kizhake S, King HM, Mallareddy JR, Case AJ, Huxford T, Natarajan A. Dimers of isatin derived a-methylene-?-butyrolactone as potent anti-cancer agents. Bioorg Med Chem Lett. 2022 06 01; 65:128713.

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Ko MS, Cohen SN, Polley S, Mahata SK, Biswas T, Huxford T, Ghosh G. Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-?B through a targetable second interaction with upstream activator IKK2. J Biol Chem. 2022 05; 298(5):101864.

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Rizor A, Pajarillo E, Nyarko-Danquah I, Digman A, Mooneyham L, Son DS, Aschner M, Lee E. Manganese-induced reactive oxygen species activate I?B kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro. Neurotoxicology. 2021 09; 86:94-103.

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