Down-Regulation

"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Descriptor ID	D015536
MeSH Number(s)	G02.111.240 G05.308.200 G07.690.773.937
Concept/Terms	Down-Regulation Down-Regulation Down Regulation Downregulation Down-Regulation (Physiology) Receptor Down-Regulation Receptor Down-Regulation Down-Regulation, Receptor

Below are MeSH descriptors whose meaning is more general than "Down-Regulation".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Down-Regulation [G02.111.240]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Down-Regulation [G05.308.200]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Down-Regulation [G07.690.773.937]

Below are MeSH descriptors whose meaning is related to "Down-Regulation".

Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.

Bar chart showing 318 publications over 29 distinct years, with a maximum of 25 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	1	1
1997	0	4	4
1998	0	3	3
1999	1	1	2
2000	0	5	5
2001	1	2	3
2002	0	5	5
2003	2	10	12
2004	1	10	11
2005	5	20	25
2006	3	18	21
2007	4	15	19
2008	1	14	15
2009	7	8	15
2010	5	18	23
2011	4	17	21
2012	2	16	18
2013	4	16	20
2014	3	9	12
2015	1	11	12
2016	1	15	16
2017	1	12	13
2018	2	6	8
2019	2	11	13
2020	1	5	6
2021	1	7	8
2022	0	5	5
2023	0	1	1

Below are the most recent publications written about "Down-Regulation" by people in Profiles.

Sugawara S, Hueber B, Woolley G, Terry K, Kroll K, Manickam C, Ram DR, Ndhlovu LC, Goepfert P, Jost S, Reeves RK. Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism. PLoS Pathog. 2023 09; 19(9):e1011629.

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Adinew GM, Messeha SS, Taka E, Badisa RB, Soliman KFA. Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells. Nutrients. 2022 Nov 13; 14(22).

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Wang YC, Tsai MC, Chen YS, Hsieh PM, Hung CM, Lin HY, Hsu YC, Yeh JH, Hsiao P, Su YC, Ma CH, Lee CY, Lin CC, Shu CW, Li YC, Tsai MH, Lin JY, Peng WH, Yu ML, Lin CW. NPRL2 down-regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression. Hepatol Commun. 2022 Dec; 6(12):3563-3577.

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Liu X, Chipurupalli S, Jiang P, Tavasoli M, Yoo BH, McPhee M, Mazinani S, Francia G, Kerbel RS, Rosen KV. ErbB2/Her2-dependent downregulation of a cell death-promoting protein BLNK in breast cancer cells is required for 3D breast tumor growth. Cell Death Dis. 2022 Aug 06; 13(8):687.

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Gant DMA, Parris AB, Yang X. Metformin-induced downregulation of c-Met is a determinant of sensitivity in MDA-MB-468 breast cancer cells. Biochem Biophys Res Commun. 2022 07 12; 613:100-106.

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Adinew G, Messeha SS, Badisa R, Taka E, Soliman KFA. Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD-L1 in MDA-MB-231 Triple-Negative Breast Cancer Cells. FASEB J. 2022 05; 36 Suppl 1.

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Rivera-Ortiz J, Pla-Tenorio J, Cruz ML, Colon K, Perez-Morales J, Rodriguez JA, Martinez-Sicari J, Noel RJ. Blockade of beta adrenergic receptors protects the blood brain barrier and reduces systemic pathology caused by HIV-1 Nef protein. PLoS One. 2021; 16(11):e0259446.

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Chuang TD, Quintanilla D, Boos D, Khorram O. Long Noncoding RNA MIAT Modulates the Extracellular Matrix Deposition in Leiomyomas by Sponging MiR-29 Family. Endocrinology. 2021 11 01; 162(11).

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Li H, Li QQ, Hong Y. Global gene expression signatures in response to citrate-coated silver nanoparticles exposure. Toxicology. 2021 09; 461:152898.

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Wang B, Qian JY, Tang TT, Lin LL, Yu N, Guo HL, Ni WJ, Lv LL, Wen Y, Li ZL, Wu M, Cao JY, Liu BC. VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy. Diabetes. 2021 11; 70(11):2639-2651.

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