Structure-Activity Relationship

"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Descriptor ID	D013329
MeSH Number(s)	G02.111.830 G07.690.773.997
Concept/Terms	Structure-Activity Relationship Structure-Activity Relationship Relationship, Structure-Activity Relationships, Structure-Activity Structure Activity Relationship Structure-Activity Relationships

Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Structure-Activity Relationship [G02.111.830]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Structure-Activity Relationship [G07.690.773.997]

Below are MeSH descriptors whose meaning is related to "Structure-Activity Relationship".

Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".

Structure-Activity Relationship
Quantitative Structure-Activity Relationship

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.

Bar chart showing 374 publications over 30 distinct years, with a maximum of 29 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	6	6
1997	0	2	2
1998	0	4	4
1999	0	2	2
2000	0	5	5
2001	0	4	4
2002	0	11	11
2003	0	9	9
2004	0	13	13
2005	0	8	8
2006	0	12	12
2007	1	13	14
2008	0	14	14
2009	0	10	10
2010	0	20	20
2011	0	17	17
2012	0	17	17
2013	0	21	21
2014	2	18	20
2015	0	29	29
2016	1	26	27
2017	0	18	18
2018	0	13	13
2019	0	12	12
2020	0	26	26
2021	0	9	9
2022	0	4	4
2023	0	6	6
2024	0	15	15
2025	0	6	6

Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.

Saleh M, Thabet MM, Kumari J, Mostafa YA, Sriram D, Suganuma K, Kandeel M, Abdu-Allah HHM. Design, Synthesis, Biological Evaluation, and In Silico Studies of New Nitazoxanide Derivatives: Toward Broad-Spectrum Antimicrobial Agents. Arch Pharm (Weinheim). 2025 Sep; 358(9):e70091.

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Acosta-Mercado J, Oliveras-Alsina A, Marcano-Maiz AI, Rivera-Torres AP, Cordero-Gimenez KT, Malavez-Cajigas S, Bayro MJ, Ramos-Benitez MJ, Pi?ero Cruz DM. Evaluating Naphthalene-Modified Metallosalen Complexes as Anticancer Agents. J Med Chem. 2025 Jul 24; 68(14):14300-14311.

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Okpattah D, Karki A, Pillarsetty NVK, Harding WW. Synthesis and evaluation of aporphinoid 5-HT7AR ligands as inhibitors of PC3 prostate cancer cell growth. Bioorg Med Chem Lett. 2025 Dec 01; 128:130328.

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Daniels MH, Castro J, Lee YT, Gotur D, Knockenhauer KE, Grigoriu S, Lockbaum GJ, Cheong JE, Lu C, Brennan D, Buker SM, Liu J, Yao S, Sparling BA, Sickmier EA, Ribich S, Blakemore SJ, Silver SJ, Boriack-Sjodin PA, Duncan KW, Copeland RA. Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9. J Med Chem. 2025 May 08; 68(9):9537-9554.

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Aishwarya S, Torres GC, Lopez-Saenz JA, Gutierrez DA, Kumar S, Madarakhandi A, Metikurki B, Teraiya N, Aguilera RJ, Karki SS. Synthesis of novel pyridazine and pyrimidine linked pyrazole derivatives as DNA ligase 1 and IV inhibitors that induce apoptosis. Chem Biol Interact. 2025 Jun 01; 414:111509.

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Mihaylova V, Iliev I, Vasileva A, Mazzio E, Mochona B, Mateeva N, Tasheva D. Synthesis and Evaluation of the Antiproliferative Activity of the Derivatives of 3,5-Diaryl-3,4-dihydro-2H-pyrrole-2-carboxylic Acids. Molecules. 2025 Apr 03; 30(7).

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Nie Z, Bonnert R, Tsien J, Deng X, Higgs C, El Mazouni F, Zhang X, Li R, Ho N, Feher V, Paulsen J, Shackleford DM, Katneni K, Chen G, Ng ACF, McInerney M, Wang W, Saunders J, Collins D, Yan D, Li P, Campbell M, Patil R, Ghoshal A, Mondal P, Kundu A, Chittimalla R, Mahadeva M, Kokkonda S, White J, Das R, Mukherjee P, Angulo-Barturen I, Jim?nez-D?az MB, Malmstrom R, Lawrenz M, Rodriguez-Granillo A, Rathod PK, Tomchick DR, Palmer MJ, Laleu B, Qin T, Charman SA, Phillips MA. Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J Med Chem. 2025 01 09; 68(1):590-637.

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Poje G, ?akic D, Marinovic M, You J, Tarpley M, Williams KP, Golub N, Dernov?ek J, Toma?ic T, Be?ic E, Rajic Z. Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids. Acta Pharm. 2024 Dec 01; 74(4):595-612.

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VanKoten HW, Pence BC, Klinkenberg JR, Das S, Patterson SE. Synthesis and evaluation of anti-Giardia activity of oseltamivir analogs. Bioorg Med Chem Lett. 2025 Feb 01; 116:130035.

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Bhalodiya SS, Parmar MP, Patel CD, Patel SG, Vala DP, Suresh N, Jayachandran B, Kumar Arumugam M, Narayan M, Patel HM. Acetic Acid-Driven One-Pot Synthesis of 4,7-dihydro-[1,2,3]thiadiazolo[5,4-b]pyridine-6-carboxamides and Pharmacological Evaluations. ChemMedChem. 2025 Jan 14; 20(2):e202400595.

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