"Paxillin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.
| Descriptor ID |
D051419
|
| MeSH Number(s) |
D12.644.360.024.316 D12.776.157.057.092 D12.776.476.024.397 D12.776.512.374 D12.776.744.665
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Paxillin".
Below are MeSH descriptors whose meaning is more specific than "Paxillin".
This graph shows the total number of publications written about "Paxillin" by people in this website by year, and whether "Paxillin" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Paxillin" by people in Profiles.
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Sherchan P, Huang L, Akyol O, Reis C, Tang J, Zhang JH. Recombinant Slit2 Reduces Surgical Brain Injury Induced Blood Brain Barrier Disruption via Robo4 Dependent Rac1 Activation in a Rodent Model. Sci Rep. 2017 04 07; 7(1):746.
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Karna P, Rida PC, Turaga RC, Gao J, Gupta M, Fritz A, Werner E, Yates C, Zhou J, Aneja R. A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1a axis and disrupting cell polarity and migration. Carcinogenesis. 2012 Sep; 33(9):1769-81.
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Pribic J, Brazill D. Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells. Cell Signal. 2012 Aug; 24(8):1531-40.
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Pribic J, Garcia R, Kong M, Brazill D. Paxillin and phospholipase D interact to regulate actin-based processes in Dictyostelium discoideum. Eukaryot Cell. 2011 Jul; 10(7):977-84.
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Duran MB, Rahman A, Colten M, Brazill D. Dictyostelium discoideum paxillin regulates actin-based processes. Protist. 2009 May; 160(2):221-32.
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Laczko R, Szauter KM, Jansen MK, Hollosi P, Muranyi M, Molnar J, Fong KS, Hinek A, Csiszar K. Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes. Neuropathol Appl Neurobiol. 2007 Dec; 33(6):631-43.
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Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T, et al. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J Biol Chem. 1995 Mar 10; 270(10):5039-47.