Signal Transduction

"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor ID	D015398
MeSH Number(s)	G02.111.820 G04.835
Concept/Terms	Signal Transduction Signal Transduction Signal Transductions Transduction, Signal Transductions, Signal Signal Transduction Systems Signal Transduction System System, Signal Transduction Systems, Signal Transduction Signal Pathways Signal Pathways Pathway, Signal Pathways, Signal Signal Pathway Signal Transduction Pathways Signal Transduction Pathways Pathway, Signal Transduction Pathways, Signal Transduction Signal Transduction Pathway Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transductions Signal Transduction, Receptor-Mediated Signal Transductions, Receptor-Mediated Receptor Mediated Signal Transduction

Below are MeSH descriptors whose meaning is more general than "Signal Transduction".

Below are MeSH descriptors whose meaning is related to "Signal Transduction".

Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.

Bar chart showing 1678 publications over 30 distinct years, with a maximum of 101 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	4	6
1997	4	3	7
1998	6	9	15
1999	6	11	17
2000	5	9	14
2001	3	7	10
2002	15	25	40
2003	16	30	46
2004	15	42	57
2005	24	35	59
2006	25	29	54
2007	25	34	59
2008	22	38	60
2009	21	46	67
2010	18	39	57
2011	23	72	95
2012	20	62	82
2013	26	62	88
2014	28	70	98
2015	25	74	99
2016	16	66	82
2017	27	74	101
2018	20	77	97
2019	24	70	94
2020	28	49	77
2021	10	49	59
2022	3	20	23
2023	4	26	30
2024	21	31	52
2025	3	30	33

Below are the most recent publications written about "Signal Transduction" by people in Profiles.

Chuang TD, Wiseman A, Alfaro G, Rysling S, Ton N, Baghdasarian D, Khorram O. Transcriptomic and functional analysis of fibroid extracellular vesicles. Clin Sci (Lond). 2026 May 20; 140(5):805-824.

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Colomer-Winter C, Nair ZJ, Chua JYJ, Jabli S, Roch M, Cazenave-Gassiot A, Sierra R, Andrey DO, Chng SS, Kline KA. A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin. Proc Natl Acad Sci U S A. 2026 Apr 28; 123(17):e2532437123.

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Centeno-Girona H, L?pez-Acevedo SN, Zen?n-Mel?ndez C, D?az-Miranda OL, Caraballo EV. Bidirectional Interactions Between Immune Regulation and the Insulin-like Growth Factor Axis in Colorectal Cancer. Int J Mol Sci. 2026 Apr 20; 27(8).

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Kumaresan V, Pahari S, Hung CY, Hermann BP, Schlesinger LS, Seshu J. Role of dual specificity phosphatase 1 in influencing inflammatory pathways in macrophages modulated by Borrelia burgdorferi lipoproteins. Front Immunol. 2026; 17:1766756.

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Sidhu RS, Ramar V, Safir T, Jones T, Guo S, Wang G, Liu M. Rap1b promotes glioma growth and stemness via regulation of Notch1 and VEGFR2 signaling pathways. Cell Signal. 2026 Jul; 143:112457.

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Aponte Ramos L, Pena D?az X, Cruz S?nchez RM, Rodr?guez De Jes?s AE, Cantres Rosario YM, Tosado Rodr?guez EL, Roche Lima A, Mel?ndez LM, Chiesa R. Neuroproteomic Profiling of the Anxiolytic Potential of Stypopodium zonale in Drosophila. Int J Mol Sci. 2026 Feb 27; 27(5).

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Li Y, Al Rimon R, Wang F, Li H, Epelman S, Tallquist MD, Westover L, Oudit GY, Kassiri Z. Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction. Cardiovasc Res. 2026 Feb 24; 122(1):112-131.

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Elia A, Parodi-Rullan R, Vazquez-Torres R, Carey A, Zhao H, Javadov S, Fossati S. Amyloid ? Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease. Adv Sci (Weinh). 2026 Apr; 13(20):e11924.

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Thompson SM, Yaple VS, Searle GH, Phan QM, Makkar J, Cheng X, Liu R, Pulawska-Czub A, Yanke C, Williams NM, Busch IV, Duong TT, Corneto MV, Jordan ZS, Roy D, Salmon AB, Slayden OD, Hermann BP, Stoltz DA, Welsh MJ, Glass IA, Kobielak K, Nie Q, Jin S, Jansen HT, Ciccarelli M, Plikus MV, Driskell IM, Driskell RR. Rete ridges form via evolutionarily distinct mechanisms in mammalian skin. Nature. 2026 03; 651(8104):135-145.

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Read GH, Pacheco JV, Baumann B, Richards ZA, Deaton R, Macias V, Kajdacsy-Balla A, Kittles R, Abern MR, Nonn L. Dysregulation of estrogen signaling and HSD17B7 in the prostate stroma of African American men. Endocrinology. 2026 Feb 04; 167(3).

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