Signal Transduction

"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor ID	D015398
MeSH Number(s)	G02.111.820 G04.835
Concept/Terms	Signal Transduction Signal Transduction Signal Transductions Transduction, Signal Transductions, Signal Signal Transduction Systems Signal Transduction System System, Signal Transduction Systems, Signal Transduction Signal Pathways Signal Pathways Pathway, Signal Pathways, Signal Signal Pathway Signal Transduction Pathways Signal Transduction Pathways Pathway, Signal Transduction Pathways, Signal Transduction Signal Transduction Pathway Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transductions Signal Transduction, Receptor-Mediated Signal Transductions, Receptor-Mediated Receptor Mediated Signal Transduction

Below are MeSH descriptors whose meaning is more general than "Signal Transduction".

Below are MeSH descriptors whose meaning is related to "Signal Transduction".

Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.

Bar chart showing 1420 publications over 31 distinct years, with a maximum of 91 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	2	3	5
1994	2	5	7
1995	2	2	4
1996	2	3	5
1997	4	3	7
1998	5	9	14
1999	6	10	16
2000	5	9	14
2001	3	6	9
2002	10	21	31
2003	15	28	43
2004	15	42	57
2005	24	35	59
2006	24	28	52
2007	26	32	58
2008	22	34	56
2009	20	46	66
2010	14	39	53
2011	22	66	88
2012	17	59	76
2013	24	58	82
2014	26	63	89
2015	19	69	88
2016	16	54	70
2017	25	66	91
2018	16	66	82
2019	23	60	83
2020	18	30	48
2021	8	41	49
2022	3	12	15
2023	0	3	3

Below are the most recent publications written about "Signal Transduction" by people in Profiles.

Afangbedji N, Kumari N, Diaz S, Wen F, Taylor JG, Nekhai S, Jerebtsova M. Soluble urokinase-type plasminogen activator receptor in sickle cell disease-associated chronic kidney disease. Blood Adv. 2023 05 09; 7(9):1854-1857.

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Hara A, Tallquist MD. Fibroblast and Immune Cell Cross-Talk in Cardiac Fibrosis. Curr Cardiol Rep. 2023 06; 25(6):485-493.

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Meliambro K, Yang Y, de Cos M, Rodriguez Ballestas E, Malkin C, Haydak J, Lee JR, Salem F, Mariani LH, Gordon RE, Basgen JM, Wen HH, Fu J, Azeloglu EU, He JC, Wong JS, Campbell KN. KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression. JCI Insight. 2023 04 10; 8(7).

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Grant AH, Rodriguez AC, Rodriguez Moncivais OJ, Sun S, Li L, Mohl JE, Leung MY, Kirken RA, Rodriguez G. JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling. Int J Mol Sci. 2023 Apr 06; 24(7).

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Boghdeh NA, McGraw B, Barrera MD, Anderson C, Baha H, Risner KH, Ogungbe IV, Alem F, Narayanan A. Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses. Viruses. 2023 02 28; 15(3).

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Ortiz-Rivera J, Nu?ez R, Kucheryavykh Y, Kucheryavykh L. The PYK2 inhibitor PF-562271 enhances the effect of temozolomide on tumor growth in a C57Bl/6-Gl261 mouse glioma model. J Neurooncol. 2023 Feb; 161(3):593-604.

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Holmberg R, Robinson M, Gilbert SF, Lujano-Olazaba O, Waters JA, Kogan E, Velasquez CLR, Stevenson D, Cruz LS, Alexander LJ, Lara J, Mu EM, Camillo JR, Bitler BG, Huxford T, House CD. TWEAK-Fn14-RelB Signaling Cascade Promotes Stem Cell-like Features that Contribute to Post-Chemotherapy Ovarian Cancer Relapse. Mol Cancer Res. 2023 02 01; 21(2):170-186.

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Joddar B, Loyola CD, Ramirez SP, Singh I. Inhibition of ERK 1/2 pathway downregulates YAP1/TAZ signaling in human cardiomyocytes exposed to hyperglycemic conditions. Biochem Biophys Res Commun. 2023 03 12; 648:72-80.

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Sun H, Chen Y, Yan K, Shao Y, Zhang QC, Lin Y, Xi Q. Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs. EMBO J. 2023 02 01; 42(3):e112058.

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Zhou B, Basu J, Kazmi HR, Chitrala KN, Mo X, Preston-Alp S, Cai KQ, Kappes D, Zaidi MR. Interferon-gamma signaling promotes melanoma progression and metastasis. Oncogene. 2023 01; 42(5):351-363.

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