Signal Transduction

"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor ID	D015398
MeSH Number(s)	G02.111.820 G04.835
Concept/Terms	Signal Transduction Signal Transduction Signal Transductions Transduction, Signal Transductions, Signal Signal Transduction Systems Signal Transduction System System, Signal Transduction Systems, Signal Transduction Signal Pathways Signal Pathways Pathway, Signal Pathways, Signal Signal Pathway Signal Transduction Pathways Signal Transduction Pathways Pathway, Signal Transduction Pathways, Signal Transduction Signal Transduction Pathway Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transductions Signal Transduction, Receptor-Mediated Signal Transductions, Receptor-Mediated Receptor Mediated Signal Transduction

Below are MeSH descriptors whose meaning is more general than "Signal Transduction".

Below are MeSH descriptors whose meaning is related to "Signal Transduction".

Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.

Bar chart showing 1442 publications over 31 distinct years, with a maximum of 92 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	5	7
1995	2	2	4
1996	2	3	5
1997	4	3	7
1998	4	8	12
1999	6	12	18
2000	5	9	14
2001	3	6	9
2002	10	21	31
2003	15	28	43
2004	15	43	58
2005	24	35	59
2006	24	27	51
2007	26	34	60
2008	22	34	56
2009	20	46	66
2010	14	41	55
2011	23	67	90
2012	16	56	72
2013	24	57	81
2014	27	65	92
2015	20	70	90
2016	16	56	72
2017	25	66	91
2018	16	63	79
2019	22	62	84
2020	20	32	52
2021	8	43	51
2022	3	12	15
2023	3	14	17
2024	0	1	1

Below are the most recent publications written about "Signal Transduction" by people in Profiles.

Rodriguez D, Church KA, Smith CT, Vanegas D, Cardona SM, Muzzio IA, Nash KR, Cardona AE. Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina. Int J Mol Sci. 2024 Jan 31; 25(3).

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Eni-Aganga I, Lanaghan ZM, Ismail F, Korolkova O, Goodwin JS, Balasubramaniam M, Dash C, Pandhare J. KLF6 activates Sp1-mediated prolidase transcription during TGF-?1 signaling. J Biol Chem. 2024 Feb; 300(2):105605.

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Ahmed SA, Mendonca P, Messeha SS, Oriaku ET, Soliman KFA. The Anticancer Effects of Marine Carotenoid Fucoxanthin through Phosphatidylinositol 3-Kinase (PI3K)-AKT Signaling on Triple-Negative Breast Cancer Cells. Molecules. 2023 Dec 21; 29(1).

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Yu J, Li J, Matei N, Wang W, Tang L, Pang J, Li X, Fang L, Tang J, Zhang JH, Yan M. Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats. Exp Neurol. 2024 Mar; 373:114656.

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Edosuyi O, Igbe I, Oyekan A. Fumarate and its downstream signalling pathways in the cardiorenal system: Recent insights and novel expositions in the etiology of hypertension. Eur J Pharmacol. 2023 Dec 15; 961:176186.

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Xie G, Shan L, Yang C, Liu Y, Pang X, Teng S, Wu TC, Gu X. Recombinant immunotoxin induces tumor intrinsic STING signaling against head and neck squamous cell carcinoma. Sci Rep. 2023 10 28; 13(1):18476.

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Das S, Somisetty VS, Ulven SM, Matthews J. Resveratrol and 3,3'-Diindolylmethane Differentially Regulate Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha Activity through Multiple Transcriptomic Targets in MCF-7 Human Breast Cancer Cells. Int J Mol Sci. 2023 Sep 26; 24(19).

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Sugawara S, Hueber B, Woolley G, Terry K, Kroll K, Manickam C, Ram DR, Ndhlovu LC, Goepfert P, Jost S, Reeves RK. Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism. PLoS Pathog. 2023 09; 19(9):e1011629.

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Rodriguez G, Martinez GS, Negrete OD, Sun S, Guo W, Xie Y, Li L, Xiao C, Ross JA, Kirken RA. JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation. Int J Mol Sci. 2023 Jul 25; 24(15).

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Banerjee S, Xu W, Doctor A, Driss A, Nezhat C, Sidell N, Taylor RN, Thompson WE, Chowdhury I. TNFa-Induced Altered miRNA Expression Links to NF-?B Signaling Pathway in Endometriosis. Inflammation. 2023 Dec; 46(6):2055-2070.

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