Nucleic Acid Denaturation

"Nucleic Acid Denaturation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.

Descriptor ID	D009691
MeSH Number(s)	E05.393.640 G02.111.603 G05.627
Concept/Terms	Nucleic Acid Denaturation Nucleic Acid Denaturation Acid Denaturation, Nucleic Denaturation, Nucleic Acid Nucleic Acid Denaturations RNA Denaturation RNA Denaturation Denaturation, RNA DNA Denaturation DNA Denaturation Denaturation, DNA DNA Melting

Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Denaturation".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Nucleic Acid Denaturation [E05.393.640]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Nucleic Acid Denaturation [G02.111.603]
Genetic Phenomena [G05]
Nucleic Acid Denaturation [G05.627]

Below are MeSH descriptors whose meaning is related to "Nucleic Acid Denaturation".

Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Denaturation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nucleic Acid Denaturation" by people in this website by year, and whether "Nucleic Acid Denaturation" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2003

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2002	1	1
2003	2	2
2006	1	1
2012	1	1
2015	1	1

Below are the most recent publications written about "Nucleic Acid Denaturation" by people in Profiles.

Zhu A, Guan X, Gu X, Xie G. Probe-free allele-specific copy number detection and analysis of tumors. Anal Biochem. 2016 Mar 15; 497:95-102.

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Birdsell DN, Pearson T, Price EP, Hornstra HM, Nera RD, Stone N, Gruendike J, Kaufman EL, Pettus AH, Hurbon AN, Buchhagen JL, Harms NJ, Chanturia G, Gyuranecz M, Wagner DM, Keim PS. Melt analysis of mismatch amplification mutation assays (Melt-MAMA): a functional study of a cost-effective SNP genotyping assay in bacterial models. PLoS One. 2012; 7(3):e32866.

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Wang X, Leiendecker-Foster C, Acton RT, Barton JC, McLaren CE, McLaren GD, Gordeuk VR, Eckfeldt JH. Heme carrier protein 1 (HCP1) genetic variants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study participants. Blood Cells Mol Dis. 2009 Mar-Apr; 42(2):150-4.

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Bratu DP. Molecular beacons: Fluorescent probes for detection of endogenous mRNAs in living cells. Methods Mol Biol. 2006; 319:1-14.

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Gannett PM, Heavner S, Daft JR, Shaughnessy KH, Epperson JD, Greenbaum NL. Synthesis, properties, and NMR studies of a C8-phenylguanine modified oligonucleotide that preferentially adopts the Z DNA conformation. Chem Res Toxicol. 2003 Oct; 16(10):1385-94.

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Forde G, Flood A, Salter L, Hill G, Gorb L, Leszczynski J. Theoretical ab initio study of the effects of methylation on structure and stability of G:C Watson-Crick base pair. J Biomol Struct Dyn. 2003 Jun; 20(6):811-7.

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Gannett PM, Darian E, Powell J, Johnson EM, Mundoma C, Greenbaum NL, Ramsey CM, Dalal NS, Budil DE. Probing triplex formation by EPR spectroscopy using a newly synthesized spin label for oligonucleotides. Nucleic Acids Res. 2002 Dec 01; 30(23):5328-37.

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Valenzuela MS. An autonomously replicating sequence from HeLa DNA shows a similar organization to the yeast ARS1 element. Mol Gen Genet. 1990 Feb; 220(3):361-5.

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Valenzuela MS, Siddiqui KA. Bidirectional sequencing of supercoiled plasmid DNA. Anal Biochem. 1989 Dec; 183(2):258-62.

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Hubbard K, Ide H, Erlanger BF, Wallace SS. Characterization of antibodies to dihydrothymine, a radiolysis product of DNA. Biochemistry. 1989 May 16; 28(10):4382-7.

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