Gene Targeting

"Gene Targeting" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.

Descriptor ID	D018390
MeSH Number(s)	E05.393.335
Concept/Terms	Gene Targeting Gene Targeting Gene Targetings Targeting, Gene Targetings, Gene

Below are MeSH descriptors whose meaning is more general than "Gene Targeting".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]

Below are MeSH descriptors whose meaning is more specific than "Gene Targeting".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Targeting" by people in this website by year, and whether "Gene Targeting" was a major or minor topic of these publications.

Bar chart showing 33 publications over 17 distinct years, with a maximum of 4 publications in 2004 and 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	3	3
2002	0	3	3
2003	1	0	1
2004	0	4	4
2005	3	1	4
2006	1	1	2
2007	2	1	3
2008	1	1	2
2009	0	1	1
2012	1	0	1
2013	1	1	2
2014	0	1	1
2015	0	1	1
2016	0	1	1
2017	0	1	1
2019	0	2	2
2020	1	0	1

Below are the most recent publications written about "Gene Targeting" by people in Profiles.

Salanga MC, Brun NR, Francolini RD, Stegeman JJ, Goldstone JV. CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae. Toxicol Sci. 2020 03 01; 174(1):51-62.

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Schick E, McCaffery SD, Keblish EE, Thakurdin C, Emerson MM. Lineage tracing analysis of cone photoreceptor associated cis-regulatory elements in the developing chicken retina. Sci Rep. 2019 06 27; 9(1):9358.

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Xu C, Ooi WF, Qamra A, Tan J, Chua BY, Ho SWT, Das K, Adam Isa ZF, Li Z, Yao X, Yan T, Xing M, Huang KK, Lin JS, Nandi T, Tay ST, Lee MH, Tan ALK, Ong X, Ashktorab H, Smoot D, Li S, Ng SC, Teh BT, Tan P. HNF4a pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer. Gut. 2020 02; 69(2):231-242.

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DeLay BD, Corkins ME, Hanania HL, Salanga M, Deng JM, Sudou N, Taira M, Horb ME, Miller RK. Tissue-Specific Gene Inactivation in Xenopus laevis: Knockout of lhx1 in the Kidney with CRISPR/Cas9. Genetics. 2018 Feb; 208(2):673-686.

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Schick JA, Seisenberger C, Beig J, B?rger A, Iyer V, Maier V, Perera S, Rosen B, Skarnes WC, Wurst W. CRISPR-Cas9 enables conditional mutagenesis of challenging loci. Sci Rep. 2016 09 01; 6:32326.

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Chapman KM, Medrano GA, Jaichander P, Chaudhary J, Waits AE, Nobrega MA, Hotaling JM, Ober C, Hamra FK. Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells. Cell Rep. 2015 Mar 24; 10(11):1828-35.

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Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS. Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis. 2014 May; 35(5):1084-91.

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Owens JB, Mauro D, Stoytchev I, Bhakta MS, Kim MS, Segal DJ, Moisyadi S. Transcription activator like effector (TALE)-directed piggyBac transposition in human cells. Nucleic Acids Res. 2013 Oct; 41(19):9197-207.

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Zhang J, Pacifico R, Cawley D, Feinstein P, Bozza T. Ultrasensitive detection of amines by a trace amine-associated receptor. J Neurosci. 2013 Feb 13; 33(7):3228-39.

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Owens JB, Urschitz J, Stoytchev I, Dang NC, Stoytcheva Z, Belcaid M, Maragathavally KJ, Coates CJ, Segal DJ, Moisyadi S. Chimeric piggyBac transposases for genomic targeting in human cells. Nucleic Acids Res. 2012 Aug; 40(14):6978-91.

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