Gene Knockout Techniques

"Gene Knockout Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques to alter a gene sequence that result in an inactivated gene, or one in which the expression can be inactivated at a chosen time during development to study the loss of function of a gene.

Descriptor ID	D055786
MeSH Number(s)	E05.393.335.750
Concept/Terms	Gene Knockout Techniques Gene Knockout Techniques Gene Knockout Technique Knockout Technique, Gene Knockout Techniques, Gene Technique, Gene Knockout Techniques, Gene Knockout Gene Knockout Gene Knockouts Knockout, Gene Knockouts, Gene Gene Knock-Out Techniques Gene Knock-Out Technique Knock-Out Technique, Gene Knock-Out Techniques, Gene Technique, Gene Knock-Out Techniques, Gene Knock-Out Gene Knock Out Gene Knock Outs Knock Out, Gene Knock Outs, Gene Out, Gene Knock Outs, Gene Knock Gene Knock Out Techniques

Below are MeSH descriptors whose meaning is more general than "Gene Knockout Techniques".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]
Gene Knockout Techniques [E05.393.335.750]

Below are MeSH descriptors whose meaning is related to "Gene Knockout Techniques".

Below are MeSH descriptors whose meaning is more specific than "Gene Knockout Techniques".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Knockout Techniques" by people in this website by year, and whether "Gene Knockout Techniques" was a major or minor topic of these publications.

Bar chart showing 45 publications over 17 distinct years, with a maximum of 6 publications in 2011 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	2	2
2010	0	1	1
2011	0	6	6
2012	0	4	4
2013	0	2	2
2014	0	4	4
2015	0	1	1
2016	0	2	2
2017	1	5	6
2018	1	1	2
2019	0	5	5
2020	1	3	4
2021	0	2	2
2022	0	1	1
2023	0	1	1
2024	0	1	1
2025	0	1	1

Below are the most recent publications written about "Gene Knockout Techniques" by people in Profiles.

Perone DM, Annalora AJ, Goldstone JV, Dickey AN, Salanga MC, Francolini RD, Wright FA, Marcus CB, Tanguay RL, Garcia-Jaramillo M. Zebrafish Cyp1b1 knockout alters eye and brain metabolomic profiles, affecting ocular and neurobehavioral function. Toxicol Appl Pharmacol. 2025 Mar; 496:117246.

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Martinez SA, Karel IZ, Silvaroli JA, Ahmed E, Kim JY, Stayton A, Patel PS, Afjal MA, Horton T, Bohmer M, Vanichapol T, Sander V, Andrade GM, Allison CV, Mondal M, Thorson VC, Partey A, Nimkar K, Williams V, Quimby J, Ganesan L, Madhavan SM, Davidson AJ, Peterson BR, Adebiyi A, Rao R, Sweet DH, Singh P, Bennett KM, Zepeda-Orozco D, Mallipattu SK, Eisenmann ED, Sparreboom A, Rovin BH, Bajwa A, Pabla NS. Resazurin dye is an in?vivo sensor of kidney tubular function. Kidney Int. 2025 Mar; 107(3):508-520.

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Ahuja N, Hwaun E, Pungor JR, Rafiq R, Nemes S, Sakmar T, Vogt MA, Grasse B, Diaz Quiroz J, Montague TG, Null RW, Dallis DN, Gavriouchkina D, Marletaz F, Abbo L, Rokhsar DS, Niell CM, Soltesz I, Albertin CB, Rosenthal JJC. Creation of an albino squid line by CRISPR-Cas9 and its application for in?vivo functional imaging of neural activity. Curr Biol. 2023 07 10; 33(13):2774-2783.e5.

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Yu S, Doycheva DM, Gamdzyk M, Gao Y, Guo Y, Travis ZD, Tang J, Chen WX, Zhang JH. BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model. Oxid Med Cell Longev. 2022; 2022:4054938.

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Knights AJ, Liu S, Ma Y, Nudell VS, Perkey E, Sorensen MJ, Kennedy RT, Maillard I, Ye L, Jun H, Wu J. Acetylcholine-synthesizing macrophages in subcutaneous fat are regulated by ?2 -adrenergic signaling. EMBO J. 2021 12 15; 40(24):e106061.

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Magg T, Okano T, Koenig LM, Boehmer DFR, Schwartz SL, Inoue K, Heimall J, Licciardi F, Ley-Zaporozhan J, Ferdman RM, Caballero-Oteyza A, Park EN, Calderon BM, Dey D, Kanegane H, Cho K, Montin D, Reiter K, Griese M, Albert MH, Rohlfs M, Gray P, Walz C, Conn GL, Sullivan KE, Klein C, Morio T, Hauck F. Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency. Sci Immunol. 2021 06 18; 6(60).

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Mazzio E, Badisa R, Mack N, Cassim S, Zdralevic M, Pouyssegur J, Soliman KFA. Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase. Cancer Genomics Proteomics. 2020 Sep-Oct; 17(5):469-497.

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Crawford K, Diaz Quiroz JF, Koenig KM, Ahuja N, Albertin CB, Rosenthal JJC. Highly Efficient Knockout of a Squid Pigmentation Gene. Curr Biol. 2020 09 07; 30(17):3484-3490.e4.

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Arun A, Rayford KJ, Cooley A, Rachakonda G, Villalta F, Pratap S, Lima MF, Sheibani N, Nde PN. Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of Trypanosoma cruzi Infection in Heart Endothelial Cells. Int J Mol Sci. 2020 Jul 12; 21(14).

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Martins FC, Couturier DL, Paterson A, Karnezis AN, Chow C, Nazeran TM, Odunsi A, Gentry-Maharaj A, Vrvilo A, Hein A, Talhouk A, Osorio A, Hartkopf AD, Brooks-Wilson A, DeFazio A, Fischer A, Hartmann A, Hernandez BY, McCauley BM, Karpinskyj C, de Sousa CB, H?gdall C, Tiezzi DG, Herpel E, Taran FA, Modugno F, Keeney G, Nelson G, Steed H, Song H, Luk H, Benitez J, Alsop J, Koziak JM, Lester J, Rothstein JH, de Andrade JM, Lundvall L, Paz-Ares L, Robles-D?az L, Wilkens LR, Garcia MJ, Intermaggio MP, Alcaraz ML, Brett MA, Beckmann MW, Jimenez-Linan M, Anglesio M, Carney ME, Schneider M, Traficante N, Pejovic N, Singh N, Le N, Sinn P, Ghatage P, Erber R, Edwards R, Vierkant R, Ness RB, Leung S, Orsulic S, Brucker SY, Kaufmann SH, Fereday S, Gayther S, Winham SJ, Kommoss S, Pejovic T, Longacre TA, McGuire V, Rhenius V, Sieh W, Shvetsov YB, Whittemore AS, Staebler A, Karlan BY, Rodriguez-Antona C, Bowtell DD, Goode EL, H?gdall E, Candido Dos Reis FJ, Gronwald J, Chang-Claude J, Moysich KB, Kelemen LE, Cook LS, Goodman MT, Fasching PA, Crawford R, Deen S, Menon U, Huntsman DG, K?bel M, Ramus SJ, Pharoah PDP, Brenton JD. Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium. Br J Cancer. 2020 09; 123(5):793-802.

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