"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725
|
| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1994 | 1 | 0 | 1 |
| 1995 | 3 | 1 | 4 |
| 1996 | 3 | 0 | 3 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 1 | 2 |
| 1999 | 3 | 0 | 3 |
| 2000 | 1 | 1 | 2 |
| 2001 | 4 | 0 | 4 |
| 2002 | 2 | 1 | 3 |
| 2003 | 4 | 3 | 7 |
| 2004 | 7 | 3 | 10 |
| 2005 | 6 | 0 | 6 |
| 2006 | 3 | 2 | 5 |
| 2007 | 0 | 2 | 2 |
| 2008 | 3 | 1 | 4 |
| 2010 | 1 | 5 | 6 |
| 2011 | 1 | 2 | 3 |
| 2012 | 0 | 2 | 2 |
| 2013 | 4 | 1 | 5 |
| 2014 | 0 | 3 | 3 |
| 2015 | 5 | 0 | 5 |
| 2016 | 2 | 1 | 3 |
| 2017 | 0 | 2 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
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Avila JA, Memos N, Aslan A, Andrejewski T, Luine VN, Serrano PA. Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKM? and increased ?OR in the hippocampus of female mice. J Psychopharmacol. 2021 Oct; 35(10):1240-1252.
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Wang T, Zhou G, He M, Xu Y, Rusyniak WG, Xu Y, Ji Y, Simon RP, Xiong ZG, Zha XM. GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia. Stroke. 2020 12; 51(12):3690-3700.
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Zhang L, Leng TD, Yang T, Li J, Xiong ZG. Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway. Mol Neurobiol. 2020 Nov; 57(11):4754-4766.
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Odutola SO, Bridges LE, Awumey EM. Protein Kinase C Downregulation Enhanced Extracellular Ca2+-Induced Relaxation of Isolated Mesenteric Arteries from Aged Dahl Salt-Sensitive Rats. J Pharmacol Exp Ther. 2019 09; 370(3):427-435.
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Opendak M, Zanca RM, Anane E, Serrano PA, Sullivan RM. Developmental transitions in amygdala PKC isoforms and AMPA receptor expression associated with threat memory in infant rats. Sci Rep. 2018 10 02; 8(1):14679.
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Piano I, Baba K, Tosini G. Heteromeric MT1/MT2 melatonin receptors modulate the scotopic electroretinogram via PKC? in mice. Exp Eye Res. 2018 12; 177:50-54.
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Chowdhury I, Branch A, Mehrabi S, Ford BD, Thompson WE. Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival. Endocrinology. 2017 10 01; 158(10):3647-3660.
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Ma CH, Wu CH, Jou IM, Tu YK, Hung CH, Hsieh PL, Tsai KL. PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes. Redox Biol. 2018 04; 14:72-81.
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Oliver CF, Kabitzke P, Serrano P, Egan LJ, Barr GA, Shair HN, Wiedenmayer C. Repeated recall and PKM? maintain fear memories in juvenile rats. Learn Mem. 2016 12; 23(12):710-713.
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De Mello WC, Dell'Itallia LJ, Varagic J, Ferrario CM. Intracellular angiotensin-(1-12) changes the electrical properties of intact cardiac muscle. Mol Cell Biochem. 2016 Nov; 422(1-2):31-40.