"Protein Kinase C-epsilon" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS. It is targeted to specific cellular compartments in response to extracellular signals that activate G-PROTEIN-COUPLED RECEPTORS; TYROSINE KINASE RECEPTORS; and intracellular protein tyrosine kinase.
| Descriptor ID |
D051744
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.750
|
| Concept/Terms |
Protein Kinase C-epsilon- Protein Kinase C-epsilon
- Kinase C-epsilon, Protein
- PKC-epsilon Serine Threonine Kinase
- PKC epsilon Serine Threonine Kinase
- Protein Kinase C epsilon
- PKC epsilon
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-epsilon".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-epsilon".
This graph shows the total number of publications written about "Protein Kinase C-epsilon" by people in this website by year, and whether "Protein Kinase C-epsilon" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C-epsilon" by people in Profiles.
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Zuo G, Zhang T, Huang L, Araujo C, Peng J, Travis Z, Okada T, Ocak U, Zhang G, Tang J, Lu X, Zhang JH. Activation of TGR5 with INT-777 attenuates oxidative stress and neuronal apoptosis via cAMP/PKCe/ALDH2 pathway after subarachnoid hemorrhage in rats. Free Radic Biol Med. 2019 11 01; 143:441-453.
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McBride DW, Reis C, Zhang JH, Applegate R, Tang J. Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via a1-Adrenoceptor-Protein Kinase Ce-Endothelial NO Synthase Pathway in Rats. J Am Heart Assoc. 2018 03 24; 7(7).
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Nu?ez RE, Javadov S, Escobales N. Angiotensin II-preconditioning is associated with increased PKCe/PKCd ratio and prosurvival kinases in mitochondria. Clin Exp Pharmacol Physiol. 2017 Dec; 44(12):1201-1212.
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Gao L, Chen L, Lu ZZ, Gao H, Wu L, Chen YX, Zhang CM, Jiang YK, Jing Q, Zhang YY, Yang HT. Activation of a1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved postischemic myocardial performance via inhibiting MMP-2 activation. Am J Physiol Heart Circ Physiol. 2014 Jun 01; 306(11):H1569-81.
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Huang J, Guo J, Beigi F, Hodgkinson CP, Facundo HT, Zhang Z, Espinoza-Derout J, Zhou X, Pratt RE, Mirotsou M, Dzau VJ. HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. J Mol Cell Cardiol. 2014 Jan; 66:157-64.
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Chen X, Guo Z, Okoro EU, Zhang H, Zhou L, Lin X, Rollins AT, Yang H. Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2. J Biol Chem. 2012 Feb 03; 287(6):3751-9.
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Wang ZH, Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, Guan Y, Zhou ZN, Yang HT. Intermittent hypobaric hypoxia improves postischemic recovery of myocardial contractile function via redox signaling during early reperfusion. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1695-705.
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Shankar E, Vykhovanets EV, Vykhovanets OV, Maclennan GT, Singh R, Bhaskaran N, Shukla S, Gupta S. High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-?B. Prostate. 2012 Feb; 72(3):233-43.
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Nasser MW, Marjoram RJ, Brown SL, Richardson RM. Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon. J Immunol. 2005 Jun 01; 174(11):6927-33.
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Sakwe AM, Rask L, Gylfe E. Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor. J Biol Chem. 2005 Feb 11; 280(6):4436-41.