Receptor, IGF Type 1

"Receptor, IGF Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.

Descriptor ID	D017526
MeSH Number(s)	D08.811.913.696.620.682.725.400.185 D12.776.543.750.630.468 D12.776.543.750.750.400.780.400
Concept/Terms	Receptor, IGF Type 1 Receptor, IGF Type 1 Receptors, IGF-1 IGF-1 Receptors Receptors, IGF 1 IGF-1 Receptor IGF 1 Receptor Receptor, IGF-1 Receptors, Insulin-Like-Growth Factor I IGF-I Receptor IGF I Receptor Receptor, Insulin-Like Growth Factor Type 1 Receptor, IGF-I Receptor, IGF I Receptor, Insulin-Like Growth Factor I Insulin-Like-Growth Factor I Receptor Insulin Like Growth Factor I Receptor IGF Type 1 Receptor Receptor, IGF Type 1 beta Subunit Receptor, IGF Type 1 beta Subunit Receptor, IGF Type 1 alpha Subunit Receptor, IGF Type 1 alpha Subunit

Below are MeSH descriptors whose meaning is more general than "Receptor, IGF Type 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
Receptor, IGF Type 1 [D08.811.913.696.620.682.725.400.185]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
Receptor, IGF Type 1 [D12.776.543.750.630.468]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Growth Factor [D12.776.543.750.750.400]
Receptors, Somatomedin [D12.776.543.750.750.400.780]
Receptor, IGF Type 1 [D12.776.543.750.750.400.780.400]

Below are MeSH descriptors whose meaning is related to "Receptor, IGF Type 1".

Below are MeSH descriptors whose meaning is more specific than "Receptor, IGF Type 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, IGF Type 1" by people in this website by year, and whether "Receptor, IGF Type 1" was a major or minor topic of these publications.

Bar chart showing 19 publications over 14 distinct years, with a maximum of 2 publications in 2008 and 2010 and 2011 and 2015 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2003	0	1	1
2006	0	1	1
2008	0	2	2
2009	1	0	1
2010	1	1	2
2011	1	1	2
2012	0	1	1
2015	0	2	2
2016	0	1	1
2017	1	0	1
2019	1	0	1
2020	1	0	1
2024	0	2	2

Below are the most recent publications written about "Receptor, IGF Type 1" by people in Profiles.

Waters JA, Robinson M, Lujano-Olazaba O, Lucht C, Gilbert SF, House CD. Omental Preadipocytes Stimulate Matrix Remodeling and IGF Signaling to Support Ovarian Cancer Metastasis. Cancer Res. 2024 Jul 02; 84(13):2073-2089.

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Zhou AL, Swaminathan SK, Salian VS, Wang L, Curran GL, Min HK, Lowe VJ, Kandimalla KK. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier. Mol Pharm. 2024 May 06; 21(5):2176-2186.

View in: PubMed
Shi Y, Ma Z, Cheng Q, Wu Y, Parris AB, Kong L, Yang X. FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling. Biochim Biophys Acta Mol Cell Res. 2021 01; 1868(1):118877.

View in: PubMed
Cruz B, Flores RJ, Uribe KP, Espinoza EJ, Spencer CT, Serafine KM, Nazarian A, O'Dell LE. Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes. Neuropsychopharmacology. 2019 05; 44(6):1141-1151.

View in: PubMed
Hamilton N, Austin D, M?rquez-Garb?n D, Sanchez R, Chau B, Foos K, Wu Y, Vadgama J, Pietras R. Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. Int J Mol Sci. 2017 Nov 02; 18(11).

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Merritt MA, Strickler HD, Einstein MH, Yang HP, Sherman ME, Wentzensen N, Brouwer-Visser J, Cossio MJ, Whitney KD, Yu H, Gunter MJ, Huang GS. Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors. Cancer Causes Control. 2016 06; 27(6):737-48.

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Hernandez BY, Wilkens LR, Le Marchand L, Horio D, Chong CD, Loo LW. Differences in IGF-axis protein expression and survival among multiethnic breast cancer patients. Cancer Med. 2015 Mar; 4(3):354-62.

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Gerena Y, Men?ndez-Delmestre R, Skolasky RL, Hechavarria RM, P?rez S, Hilera C, Gonz?lez C, Nath A, Wojna V. Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women. J Neurovirol. 2015 Apr; 21(2):113-9.

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Candeias E, Duarte AI, Carvalho C, Correia SC, Cardoso S, Santos RX, Pl?cido AI, Perry G, Moreira PI. The impairment of insulin signaling in Alzheimer's disease. IUBMB Life. 2012 Dec; 64(12):951-7.

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Liu B, Fan Z, Edgerton SM, Yang X, Lind SE, Thor AD. Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. Cell Cycle. 2011 Sep 01; 10(17):2959-66.

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