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Richard J. Pietras, MD, PhD

TitleProfessor
Faculty RankProfessor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street
1731 E. 120th Street
Los Angeles CA 90059
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    R29CA060835     (PIETRAS, RICHARD JOSEPH)Feb 1, 1995 - Jan 31, 2000
    NIH
    GROWTH FACTOR RECEPTOR DIRECTED THERAPY IN CANCER
    Role: Principal Investigator
    R01AG014785     (PIETRAS, RICHARD JOSEPH)Aug 15, 1997 - Jun 30, 2001
    NIH
    NEW ENDOCRINE THERAPY IN OLDER WOMEN WITH BREAST CANCER
    Role: Principal Investigator
    U54CA143930     (PIETRAS, RICHARD JOSEPH)Sep 29, 2009 - Aug 31, 2021
    NIH
    (2/2) CDU/UCLA Cancer Center Partnership to Eliminate Cancer Health Disparities
    Role: Principal Investigator
    R21CA176337     (PIETRAS, RICHARD JOSEPH)Jun 1, 2013 - Mar 31, 2016
    NIH
    Development of New Therapeutics for Pancreatic Cancer Management
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. M?rquez-Garb?n DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, Wadehra M, McCloskey SA, Pietras RJ. Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models. Nutrients. 2024 Jul 22; 16(14). PMID: 39064812.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Wu Y, Tran T, Dwabe S, Sarkissyan M, Kim J, Nava M, Clayton S, Pietras R, Farias-Eisner R, Vadgama JV. Retraction Note: A83-01 inhibits TGF-?-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Res Treat. 2024 Jul; 206(1):213. PMID: 38727890.
      Citations:    Fields:    
    3. Chan AM, Aguirre B, Liu L, Mah V, Balko JM, Tsui J, Wadehra NP, Moatamed NA, Khoshchehreh M, Dillard CM, Kiyohara M, Elshimali Y, Chang HR, Marquez-Garban D, Hamilton N, Pietras RJ, Gordon LK, Wadehra M. EMP2 Serves as a Functional Biomarker for Chemotherapy-Resistant Triple-Negative Breast Cancer. Cancers (Basel). 2024 Apr 12; 16(8). PMID: 38672563.
      Citations:    
    4. Hamilton N, Austin D, M?rquez-Garb?n D, Sanchez R, Chau B, Foos K, Wu Y, Vadgama J, Pietras R. Correction: Hamilton et al. Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. Int. J. Mol. Sci. 2017, 18, 2305. Int J Mol Sci. 2024 Feb 23; 25(5). PMID: 38474325.
      Citations:    Fields:    
    5. Pegram M, Pietras R, Dang CT, Murthy R, Bachelot T, Janni W, Sharma P, Hamilton E, Saura C. Evolving perspectives on the treatment of HR+/HER2+ metastatic breast cancer. Ther Adv Med Oncol. 2023; 15:17588359231187201. PMID: 37576607.
      Citations:    
    6. Marquez-Garban DC, Morales Martinez M, Pietras RJ. Estradiol Induces Neutrophil Expansion to Promote TSC-Null Tumor Progression. Endocrinology. 2023 06 26; 164(8). PMID: 37289038.
      Citations:    Fields:    Translation:HumansCells
    7. Rangsrikitphoti P, Marquez-Garban DC, Pietras RJ, McGowan E, Boonyaratanakornkit V. Sex steroid hormones and DNA repair regulation: Implications on cancer treatment responses. J Steroid Biochem Mol Biol. 2023 03; 227:106230. PMID: 36450315.
      Citations: 2     Fields:    Translation:HumansCells
    8. Sterling C, M?rquez-Garb?n D, Vadgama JV, Pietras RJ. Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression. Cancers (Basel). 2022 Oct 21; 14(20). PMID: 36291938.
      Citations:    
    9. Young PA, M?rquez-Garb?n DC, Noor ZS, Moatamed N, Elashoff D, Grogan T, Romero T, Sasano H, Saito R, Rausch R, Hamilton N, Dubinett SM, Garon EB, Pietras RJ. Investigation of Combination Treatment With an Aromatase Inhibitor Exemestane and Carboplatin-Based Therapy for Postmenopausal Women With Advanced NSCLC. JTO Clin Res Rep. 2021 Apr; 2(4):100150. PMID: 34590007.
      Citations:    
    10. Boonyaratanakornkit V, McGowan EM, M?rquez-Garb?n DC, Burton LP, Hamilton N, Pateetin P, Pietras RJ. Progesterone Receptor Signaling in the Breast Tumor Microenvironment. Adv Exp Med Biol. 2021; 1329:443-474. PMID: 34664251.
      Citations: 3     Fields:    Translation:HumansCells
    11. Su F, Gm A, Palgunachari MN, White CR, Stessman H, Wu Y, Vadgama J, Pietras R, Nguyen D, Reddy ST, Farias-Eisner R. Bovine HDL and Dual Domain HDL-Mimetic Peptides Inhibit Tumor Development in Mice. J Cancer Res Ther Oncol. 2020; 8(1). PMID: 32462055.
      Citations:    
    12. M?rquez-Garb?n DC, Deng G, Comin-Anduix B, Garcia AJ, Xing Y, Chen HW, Cheung-Lau G, Hamilton N, Jung ME, Pietras RJ. Antiestrogens in combination with immune checkpoint inhibitors in breast cancer immunotherapy. J Steroid Biochem Mol Biol. 2019 10; 193:105415. PMID: 31226312.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    13. M?rquez-Garb?n DC, Gorr?n-Rivas M, Chen HW, Sterling C, Elashoff D, Hamilton N, Pietras RJ. Squalamine blocks tumor-associated angiogenesis and growth of human breast cancer cells with or without HER-2/neu overexpression. Cancer Lett. 2019 05 01; 449:66-75. PMID: 30771431.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    14. Young PA, Pietras RJ. Aromatase inhibitors combined with aspirin to prevent lung cancer in preclinical models. Transl Lung Cancer Res. 2018 Dec; 7(Suppl 4):S373-S376. PMID: 30705860.
      Citations:    
    15. Austin D, Hamilton N, Elshimali Y, Pietras R, Wu Y, Vadgama J. Estrogen receptor-beta is a potential target for triple negative breast cancer treatment. Oncotarget. 2018 Sep 21; 9(74):33912-33930. PMID: 30338035.
      Citations: 28     Fields:    
    16. Garon EB, Siegfried JM, Stabile LP, Young PA, Marquez-Garban DC, Park DJ, Patel R, Hu EH, Sadeghi S, Parikh RJ, Reckamp KL, Adams B, Elashoff RM, Elashoff D, Grogan T, Wang HJ, Dacic S, Brennan M, Valdes Y, Davenport S, Dubinett SM, Press MF, Slamon DJ, Pietras RJ. Randomized phase II study of fulvestrant and erlotinib compared with erlotinib alone in patients with advanced or metastatic non-small cell lung cancer. Lung Cancer. 2018 09; 123:91-98. PMID: 30089602.
      Citations: 25     Fields:    Translation:HumansCTClinical Trials
    17. Boonyaratanakornkit V, Hamilton N, M?rquez-Garb?n DC, Pateetin P, McGowan EM, Pietras RJ. Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer. Mol Cell Endocrinol. 2018 05 05; 466:51-72. PMID: 29146555.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    18. Hamilton N, Austin D, M?rquez-Garb?n D, Sanchez R, Chau B, Foos K, Wu Y, Vadgama J, Pietras R. Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. Int J Mol Sci. 2017 Nov 02; 18(11). PMID: 29099049.
      Citations: 7     Fields:    Translation:HumansCells
    19. Yaghoubian JM, Adashek J, Yaghoubian-Yazi B, Nagar M, Toomari N, Pietras RJ, Ben-Zur UM. Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy. Case Rep Cardiol. 2017; 2017:3628127. PMID: 28828188.
      Citations:    
    20. Deng X, Apple S, Zhao H, Song J, Lee M, Luo W, Wu X, Chung D, Pietras RJ, Chang HR. CD24 Expression and differential resistance to chemotherapy in triple-negative breast cancer. Oncotarget. 2017 Jun 13; 8(24):38294-38308. PMID: 28418843.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    21. Wu Y, Tran T, Dwabe S, Sarkissyan M, Kim J, Nava M, Clayton S, Pietras R, Farias-Eisner R, Vadgama JV. A83-01 inhibits TGF-?-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Res Treat. 2017 Jun; 163(3):449-460. PMID: 28337662.
      Citations: 29     Fields:    Translation:HumansCells
    22. Rankin J, Nagar M, Crosby J, Toomari N, Pietras R, Ben-Zur UM. Possible failure of novel direct-acting oral anticoagulants in management of pulmonary embolism: a case report. J Med Case Rep. 2016 Dec 03; 10(1):346. PMID: 27912791.
      Citations: 6     Fields:    Translation:Humans
    23. Kawprasertsri S, Pietras RJ, Marquez-Garban DC, Boonyaratanakornkit V. Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Cancer Lett. 2016 May 01; 374(2):279-91. PMID: 26892043.
      Citations: 9     Fields:    Translation:HumansCells
    24. Mah V, Alavi M, M?rquez-Garb?n DC, Maresh EL, Kim SR, Horvath S, Bagryanova L, Huerta-Yepez S, Chia D, Pietras R, Goodglick L. Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status. PLoS One. 2015; 10(5):e0127600. PMID: 26001082.
      Citations: 19     Fields:    Translation:Humans
    25. Hamilton N, M?rquez-Garb?n D, Mah V, Fernando G, Elshimali Y, Garb?n H, Elashoff D, Vadgama J, Goodglick L, Pietras R. Biologic roles of estrogen receptor-? and insulin-like growth factor-2 in triple-negative breast cancer. Biomed Res Int. 2015; 2015:925703. PMID: 25874233.
      Citations: 28     Fields:    Translation:HumansCells
    26. Hamilton N, Marquez-Garban D, Mah VH, Elshimali Y, Elashoff D, Garon EB, Vadgama J, Pietras R. Estrogen Receptor-? and the Insulin-Like Growth Factor Axis as Potential Therapeutic Targets for Triple-Negative Breast Cancer. Crit Rev Oncog. 2015; 20(5-6):373-90. PMID: 27279236.
      Citations: 5     Fields:    Translation:Humans
    27. Garon EB, Pietras RJ, Finn RS, Kamranpour N, Pitts S, M?rquez-Garb?n DC, Desai AJ, Dering J, Hosmer W, von Euw EM, Dubinett SM, Slamon DJ. Antiestrogen fulvestrant enhances the antiproliferative effects of epidermal growth factor receptor inhibitors in human non-small-cell lung cancer. J Thorac Oncol. 2013 Mar; 8(3):270-8. PMID: 23399957.
      Citations: 30     Fields:    Translation:HumansCells
    28. Kazmi N, M?rquez-Garb?n DC, Aivazyan L, Hamilton N, Garon EB, Goodglick L, Pietras RJ. The role of estrogen, progesterone and aromatase in human non-small-cell lung cancer. Lung Cancer Manag. 2012 Dec; 1(4):259-272. PMID: 23650476.
      Citations:    
    29. Marquez-Garban DC, Mah V, Alavi M, Maresh EL, Chen HW, Bagryanova L, Horvath S, Chia D, Garon E, Goodglick L, Pietras RJ. Progesterone and estrogen receptor expression and activity in human non-small cell lung cancer. Steroids. 2011 Aug; 76(9):910-20. PMID: 21600232.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    30. Mah V, Marquez D, Alavi M, Maresh EL, Zhang L, Yoon N, Horvath S, Bagryanova L, Fishbein MC, Chia D, Pietras R, Goodglick L. Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer. Lung Cancer. 2011 Nov; 74(2):318-25. PMID: 21511357.
      Citations: 33     Fields:    Translation:Humans
    31. M?rquez-Garb?n DC, Chen HW, Goodglick L, Fishbein MC, Pietras RJ. Targeting aromatase and estrogen signaling in human non-small cell lung cancer. Ann N Y Acad Sci. 2009 Feb; 1155:194-205. PMID: 19250205.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    32. Hurvitz SA, Pietras RJ. Rational management of endocrine resistance in breast cancer: a comprehensive review of estrogen receptor biology, treatment options, and future directions. Cancer. 2008 Nov 01; 113(9):2385-97. PMID: 18819158.
      Citations: 38     Fields:    Translation:Humans
    33. Mah V, Seligson DB, Li A, M?rquez DC, Wistuba II, Elshimali Y, Fishbein MC, Chia D, Pietras RJ, Goodglick L. Aromatase expression predicts survival in women with early-stage non small cell lung cancer. Cancer Res. 2007 Nov 01; 67(21):10484-90. PMID: 17974992.
      Citations: 66     Fields:    Translation:HumansAnimals
    34. Pietras RJ, M?rquez-Garb?n DC. Membrane-associated estrogen receptor signaling pathways in human cancers. Clin Cancer Res. 2007 Aug 15; 13(16):4672-6. PMID: 17699844.
      Citations: 70     Fields:    Translation:HumansCells
    35. Levin ER, Pietras RJ. Estrogen receptors outside the nucleus in breast cancer. Breast Cancer Res Treat. 2008 Apr; 108(3):351-61. PMID: 17592774.
      Citations: 67     Fields:    Translation:HumansCells
    36. M?rquez-Garb?n DC, Chen HW, Fishbein MC, Goodglick L, Pietras RJ. Estrogen receptor signaling pathways in human non-small cell lung cancer. Steroids. 2007 Feb; 72(2):135-43. PMID: 17276470.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    37. Pietras RJ. Biologic basis of sequential and combination therapies for hormone-responsive breast cancer. Oncologist. 2006 Jul-Aug; 11(7):704-17. PMID: 16880230.
      Citations: 17     Fields:    Translation:HumansCells
    38. Sartippour MR, Pietras R, Marquez-Garban DC, Chen HW, Heber D, Henning SM, Sartippour G, Zhang L, Lu M, Weinberg O, Rao JY, Brooks MN. The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis. 2006 Dec; 27(12):2424-33. PMID: 16785249.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    39. M?rquez DC, Chen HW, Curran EM, Welshons WV, Pietras RJ. Estrogen receptors in membrane lipid rafts and signal transduction in breast cancer. Mol Cell Endocrinol. 2006 Feb 26; 246(1-2):91-100. PMID: 16388889.
      Citations: 44     Fields:    Translation:HumansCells
    40. Pio BS, Park CK, Pietras R, Hsueh WA, Satyamurthy N, Pegram MD, Czernin J, Phelps ME, Silverman DH. Usefulness of 3'-[F-18]fluoro-3'-deoxythymidine with positron emission tomography in predicting breast cancer response to therapy. Mol Imaging Biol. 2006 Jan-Feb; 8(1):36-42. PMID: 16362149.
      Citations: 80     Fields:    Translation:Humans
    41. Weinberg OK, Marquez-Garban DC, Fishbein MC, Goodglick L, Garban HJ, Dubinett SM, Pietras RJ. Aromatase inhibitors in human lung cancer therapy. Cancer Res. 2005 Dec 15; 65(24):11287-91. PMID: 16357134.
      Citations: 80     Fields:    Translation:HumansAnimals
    42. Pietras RJ, Levin ER, Szego CM. Estrogen receptors and cell signaling. Science. 2005 Oct 07; 310(5745):51-3; author reply 51-3. PMID: 16210518.
      Citations: 15     Fields:    Translation:HumansCells
    43. Weinberg OK, Marquez-Garban DC, Pietras RJ. New approaches to reverse resistance to hormonal therapy in human breast cancer. Drug Resist Updat. 2005 Aug; 8(4):219-33. PMID: 16054421.
      Citations: 13     Fields:    Translation:Humans
    44. Pietras RJ. Overview of the FASEB 2004 summer research conference on steroid hormone receptors: integration of plasma membrane and nuclear-initiated signaling in hormone action. Steroids. 2005 May-Jun; 70(5-7):345-6. PMID: 15862815.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    45. Pietras RJ, M?rquez DC, Chen HW, Tsai E, Weinberg O, Fishbein M. Estrogen and growth factor receptor interactions in human breast and non-small cell lung cancer cells. Steroids. 2005 May-Jun; 70(5-7):372-81. PMID: 15862820.
      Citations: 85     Fields:    Translation:HumansCells
    46. Pegram MD, Pietras R, Bajamonde A, Klein P, Fyfe G. Targeted therapy: wave of the future. J Clin Oncol. 2005 Mar 10; 23(8):1776-81. PMID: 15755985.
      Citations: 14     Fields:    Translation:Humans
    47. Pietras RJ, Weinberg OK. Antiangiogenic Steroids in Human Cancer Therapy. Evid Based Complement Alternat Med. 2005 03; 2(1):49-57. PMID: 15841278.
      Citations:    
    48. Garb?n HJ, M?rquez-Garb?n DC, Pietras RJ, Ignarro LJ. Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: regulation of estrogen-dependent gene transcription. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2632-6. PMID: 15699347.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    49. Dowsett M, Nicholson RI, Pietras RJ. Biological characteristics of the pure antiestrogen fulvestrant: overcoming endocrine resistance. Breast Cancer Res Treat. 2005; 93 Suppl 1:S11-8. PMID: 16247595.
      Citations: 24     Fields:    Translation:Humans
    50. Pegram MD, Konecny GE, O'Callaghan C, Beryt M, Pietras R, Slamon DJ. Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J Natl Cancer Inst. 2004 May 19; 96(10):739-49. PMID: 15150302.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    51. Pietras RJ. Interactions between estrogen and growth factor receptors in human breast cancers and the tumor-associated vasculature. Breast J. 2003 Sep-Oct; 9(5):361-73. PMID: 12968955.
      Citations: 28     Fields:    Translation:HumansCells
    52. Nemere I, Pietras RJ, Blackmore PF. Membrane receptors for steroid hormones: signal transduction and physiological significance. J Cell Biochem. 2003 Feb 15; 88(3):438-45. PMID: 12532320.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    53. Li D, Williams JI, Pietras RJ. Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression. Oncogene. 2002 Apr 25; 21(18):2805-14. PMID: 11973639.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
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