Lewy Bodies

"Lewy Bodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.

Descriptor ID	D016631
MeSH Number(s)	A08.675.460 A11.284.420.460 A11.671.460
Concept/Terms	Lewy Bodies Lewy Bodies Lewy Body Bodies, Lewy Body, Lewy

Below are MeSH descriptors whose meaning is more general than "Lewy Bodies".

Anatomy [A]
Nervous System [A08]
Neurons [A08.675]
Lewy Bodies [A08.675.460]
Cells [A11]
Cellular Structures [A11.284]
Inclusion Bodies [A11.284.420]
Lewy Bodies [A11.284.420.460]
Neurons [A11.671]
Lewy Bodies [A11.671.460]

Below are MeSH descriptors whose meaning is more specific than "Lewy Bodies".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lewy Bodies" by people in this website by year, and whether "Lewy Bodies" was a major or minor topic of these publications.

Bar chart showing 27 publications over 18 distinct years, with a maximum of 3 publications in 2006 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	0	1
2002	0	1	1
2004	0	1	1
2005	0	2	2
2006	2	1	3
2007	1	0	1
2009	0	1	1
2010	1	1	2
2011	2	0	2
2012	1	2	3
2014	0	1	1
2015	1	0	1
2016	0	2	2
2017	1	0	1
2018	0	1	1
2019	1	1	2
2021	1	0	1
2023	0	1	1

Below are the most recent publications written about "Lewy Bodies" by people in Profiles.

Kim S, Pajarillo E, Nyarko-Danquah I, Aschner M, Lee E. Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants. Cells. 2023 02 15; 12(4).

View in: PubMed
Petyuk VA, Yu L, Olson HM, Yu F, Clair G, Qian WJ, Shulman JM, Bennett DA. Proteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss. J Proteome Res. 2021 05 07; 20(5):2266-2282.

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Abbott RD, Ross GW, Duda JE, Shin C, Uyehara-Lock JH, Masaki KH, Launer LJ, White LR, Tanner CM, Petrovitch H. Excessive daytime sleepiness and topographic expansion of Lewy pathology. Neurology. 2019 10 08; 93(15):e1425-e1432.

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Coughlin DG, Petrovitch H, White LR, Noorigian J, Masaki KH, Ross GW, Duda JE. Most cases with Lewy pathology in a population-based cohort adhere to the Braak progression pattern but 'failure to fit' is highly dependent on staging system applied. Parkinsonism Relat Disord. 2019 07; 64:124-131.

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Pajarillo E, Rizor A, Lee J, Aschner M, Lee E. The role of posttranslational modifications of a-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors. Biochim Biophys Acta Mol Basis Dis. 2019 08 01; 1865(8):1992-2000.

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Siedlak SL, Jiang Y, Huntley ML, Wang L, Gao J, Xie F, Liu J, Su B, Perry G, Wang X. TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease. J Alzheimers Dis. 2017; 58(4):1027-1033.

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Kabiraj P, Marin JE, Varela-Ramirez A, Narayan M. An 11-mer Amyloid Beta Peptide Fragment Provokes Chemical Mutations and Parkinsonian Biomarker Aggregation in Dopaminergic Cells: A Novel Road Map for "Transfected" Parkinson's. ACS Chem Neurosci. 2016 11 16; 7(11):1519-1530.

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White LR, Edland SD, Hemmy LS, Montine KS, Zarow C, Sonnen JA, Uyehara-Lock JH, Gelber RP, Ross GW, Petrovitch H, Masaki KH, Lim KO, Launer LJ, Montine TJ. Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies. Neurology. 2016 Mar 15; 86(11):1000-8.

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Abbott RD, Ross GW, Petrovitch H, Masaki KH, Launer LJ, Nelson JS, White LR, Tanner CM. Midlife milk consumption and substantia nigra neuron density at death. Neurology. 2016 Feb 09; 86(6):512-9.

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Shulman JM, Yu L, Buchman AS, Evans DA, Schneider JA, Bennett DA, De Jager PL. Association of Parkinson disease risk loci with mild parkinsonian signs in older persons. JAMA Neurol. 2014 Apr; 71(4):429-35.

View in: PubMed

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