"GTP Cyclohydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
| Descriptor ID |
D006136
|
| MeSH Number(s) |
D08.811.277.151.300
|
| Concept/Terms |
GTP Cyclohydrolase- GTP Cyclohydrolase
- Cyclohydrolase, GTP
- GTP 8-Formylhydrolase
- 8-Formylhydrolase, GTP
- GTP 8 Formylhydrolase
- GTP Ring-Opening Enzyme
- GTP Ring Opening Enzyme
- Ring-Opening Enzyme, GTP
- GTP Dihydrolase
- Dihydrolase, GTP
- 7,8-Dihydroneopterintriphosphate Synthetase
- 7,8 Dihydroneopterintriphosphate Synthetase
- Synthetase, 7,8-Dihydroneopterintriphosphate
|
Below are MeSH descriptors whose meaning is more general than "GTP Cyclohydrolase".
Below are MeSH descriptors whose meaning is more specific than "GTP Cyclohydrolase".
This graph shows the total number of publications written about "GTP Cyclohydrolase" by people in this website by year, and whether "GTP Cyclohydrolase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "GTP Cyclohydrolase" by people in Profiles.
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Hung CY, Zhu C, Kittur FS, He M, Arning E, Zhang J, Johnson AJ, Jawa GS, Thomas MD, Ding TT, Xie J. A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR. Cell Mol Life Sci. 2022 Oct 17; 79(11):553.
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Belfer I, Youngblood V, Darbari DS, Wang Z, Diaw L, Freeman L, Desai K, Dizon M, Allen D, Cunnington C, Channon KM, Milton J, Hartley SW, Nolan V, Kato GJ, Steinberg MH, Goldman D, Taylor JG. A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia. Am J Hematol. 2014 Feb; 89(2):187-93.
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Wang Z, Ferdousy F, Lawal H, Huang Z, Daigle JG, Izevbaye I, Doherty O, Thomas J, Stathakis DG, O'Donnell JM. Catecholamines up integrates dopamine synthesis and synaptic trafficking. J Neurochem. 2011 Dec; 119(6):1294-305.
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Gangula PR, Mukhopadhyay S, Ravella K, Cai S, Channon KM, Garfield RE, Pasricha PJ. Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats. Am J Physiol Gastrointest Liver Physiol. 2010 May; 298(5):G692-9.