"Caspase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
| Descriptor ID |
D053143
|
| MeSH Number(s) |
D08.811.277.656.262.500.126.550.200 D08.811.277.656.300.200.126.550.200 D12.644.360.075.405.550.200 D12.776.476.075.405.550.200
|
| Concept/Terms |
Caspase 2- Caspase 2
- ICH-1 Protease
- ICH 1 Protease
- Caspase-2
Procaspase-2- Procaspase-2
- Procaspase 2
- Pro-Caspase-2
- Pro Caspase 2
|
Below are MeSH descriptors whose meaning is more general than "Caspase 2".
Below are MeSH descriptors whose meaning is more specific than "Caspase 2".
This graph shows the total number of publications written about "Caspase 2" by people in this website by year, and whether "Caspase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspase 2" by people in Profiles.
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Ivey R, Desai M, Green K, Sinha-Hikim I, Friedman TC, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res. 2014 Jul; 46(8):568-73.
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Braga M, Sinha Hikim AP, Datta S, Ferrini MG, Brown D, Kovacheva EL, Gonzalez-Cadavid NF, Sinha-Hikim I. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis. 2008 Jun; 13(6):822-32.
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Yang S, Thor AD, Edgerton S, Yang X. Caspase-3 mediated feedback activation of apical caspases in doxorubicin and TNF-alpha induced apoptosis. Apoptosis. 2006 Nov; 11(11):1987-97.
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Jin K, Nagayama T, Mao X, Kawaguchi K, Hickey RW, Greenberg DA, Simon RP, Graham SH. Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia. J Neurochem. 2002 Apr; 81(1):25-35.
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Kitamura Y, Shimohama S, Kamoshima W, Ota T, Matsuoka Y, Nomura Y, Smith MA, Perry G, Whitehouse PJ, Taniguchi T. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Res. 1998 Jan 12; 780(2):260-9.