Caspase 1

"Caspase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.

Descriptor ID	D020170
MeSH Number(s)	D08.811.277.656.262.500.126.550.100 D08.811.277.656.300.200.126.550.100 D12.644.360.075.405.550.100 D12.776.476.075.405.550.100
Concept/Terms	Caspase 1 Caspase 1 Interleukin-1beta Converting Enzyme Converting Enzyme, Interleukin-1beta Interleukin 1beta Converting Enzyme ICE Protease IL1BC Enzyme IL-1 beta Convertase Convertase, IL-1 beta IL 1 beta Convertase beta Convertase, IL-1 CASP1 Caspase Caspase, CASP1 Interleukin-1 Converting Enzyme Converting Enzyme, Interleukin-1 Interleukin 1 Converting Enzyme IL-1 beta-Converting Enzyme IL 1 beta Converting Enzyme beta-Converting Enzyme, IL-1 Procaspase-1 Procaspase-1 Procaspase 1 Pro-Caspase-1 Pro Caspase 1

Below are MeSH descriptors whose meaning is more general than "Caspase 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Cysteine Proteases [D08.811.277.656.262]
Cysteine Endopeptidases [D08.811.277.656.262.500]
Caspases [D08.811.277.656.262.500.126]
Caspases, Initiator [D08.811.277.656.262.500.126.550]
Caspase 1 [D08.811.277.656.262.500.126.550.100]
Endopeptidases [D08.811.277.656.300]
Cysteine Endopeptidases [D08.811.277.656.300.200]
Caspases [D08.811.277.656.300.200.126]
Caspases, Initiator [D08.811.277.656.300.200.126.550]
Caspase 1 [D08.811.277.656.300.200.126.550.100]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Caspases [D12.644.360.075.405]
Caspases, Initiator [D12.644.360.075.405.550]
Caspase 1 [D12.644.360.075.405.550.100]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Caspases [D12.776.476.075.405]
Caspases, Initiator [D12.776.476.075.405.550]
Caspase 1 [D12.776.476.075.405.550.100]

Below are MeSH descriptors whose meaning is related to "Caspase 1".

Below are MeSH descriptors whose meaning is more specific than "Caspase 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Caspase 1" by people in this website by year, and whether "Caspase 1" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2013	1	1	2
2015	0	1	1
2016	1	0	1
2017	0	1	1
2021	0	1	1
2022	0	1	1

Below are the most recent publications written about "Caspase 1" by people in Profiles.

Fang Y, Wang X, Lu J, Shi H, Huang L, Shao A, Zhang A, Liu Y, Ren R, Lenahan C, Tang J, Zhang J, Zhang JH, Chen S. Inhibition of caspase-1-mediated inflammasome activation reduced blood coagulation in cerebrospinal fluid after subarachnoid haemorrhage. EBioMedicine. 2022 Feb; 76:103843.

View in: PubMed
Plassmeyer M, Alpan O, Corley MJ, Premeaux TA, Lillard K, Coatney P, Vaziri T, Michalsky S, Pang APS, Bukhari Z, Yeung ST, Evering TH, Naughton G, Latterich M, Mudd P, Spada A, Rindone N, Loizou D, Ulrik S?nder S, Ndhlovu LC, Gupta R. Caspases and therapeutic potential of caspase inhibitors in moderate-severe SARS-CoV-2 infection and long COVID. Allergy. 2022 01; 77(1):118-129.

View in: PubMed
Pan Q, Zhang Q, Chu J, Pais R, Liu S, He C, Eko FO. Chlamydia abortus Pmp18.1 Induces IL-1? Secretion by TLR4 Activation through the MyD88, NF-?B, and Caspase-1 Signaling Pathways. Front Cell Infect Microbiol. 2017; 7:514.

View in: PubMed
Rodriguez AR, Yu JJ, Navara C, Chambers JP, Guentzel MN, Arulanandam BP. Contribution of Fc?RI-associated vesicles to mast cell-macrophage communication following Francisella tularensis infection. Innate Immun. 2016 10; 22(7):567-74.

View in: PubMed
Rodriguez AR, Plascencia-Villa G, Witt CM, Yu JJ, Jos?-Yacam?n M, Chambers JP, Perry G, Guentzel MN, Arulanandam BP. Chlamydia pneumoniae promotes dysfunction of pancreatic beta cells. Cell Immunol. 2015 Jun; 295(2):83-91.

View in: PubMed
Igietseme JU, Omosun Y, Partin J, Goldstein J, He Q, Joseph K, Ellerson D, Ansari U, Eko FO, Bandea C, Zhong G, Black CM. Prevention of Chlamydia-induced infertility by inhibition of local caspase activity. J Infect Dis. 2013 Apr; 207(7):1095-104.

View in: PubMed
Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M, Verma S. Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis. J Virol. 2013 Apr; 87(7):3655-67.

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Ayala-Torres S, Moller PC, Johnson BH, Thompson EB. Characteristics of 25-hydroxycholesterol-induced apoptosis in the human leukemic cell line CEM. Exp Cell Res. 1997 Aug 25; 235(1):35-47.

View in: PubMed

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