"Caspases, Initiator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.
| Descriptor ID |
D053471
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| MeSH Number(s) |
D08.811.277.656.262.500.126.550 D08.811.277.656.300.200.126.550 D12.644.360.075.405.550 D12.776.476.075.405.550
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspases, Initiator".
Below are MeSH descriptors whose meaning is more specific than "Caspases, Initiator".
This graph shows the total number of publications written about "Caspases, Initiator" by people in this website by year, and whether "Caspases, Initiator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Caspases, Initiator" by people in Profiles.
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Casson CN, Copenhaver AM, Zwack EE, Nguyen HT, Strowig T, Javdan B, Bradley WP, Fung TC, Flavell RA, Brodsky IE, Shin S. Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. PLoS Pathog. 2013; 9(6):e1003400.
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Xiong A, Yu W, Tiwary R, Sanders BG, Kline K. Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. Mol Nutr Food Res. 2012 Jun; 56(6):923-34.
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Valent?n-Acevedo A, Sinquett FL, Covey LR. c-Rel deficiency increases caspase-4 expression and leads to ER stress and necrosis in EBV-transformed cells. PLoS One. 2011; 6(10):e25467.
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Yang S, Zhou Q, Yang X. Caspase-3 status is a determinant of the differential responses to genistein between MDA-MB-231 and MCF-7 breast cancer cells. Biochim Biophys Acta. 2007 Jun; 1773(6):903-11.