Indrani Sinha-Hikim | Profiles RNS

Indrani Sinha-Hikim, PhD

Title	Associate Professor
Faculty Rank	Associate Professor
Institution	Charles R. Drew University of Medicine and Science
Department	Internal Medicine
Address	1731 E. 120th Street, Hawkins Building 1731 E. 120th Street, Hawkins Building Los Angeles CA 90059
Phone	3235635959
vCard	Download vCard

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Hasan KM, Friedman TC, Shao X, Parveen M, Sims C, Lee DL, Espinoza-Derout J, Sinha-Hikim I, Sinha-Hikim AP. E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. Hepatology. 2019 06; 69(6):2442-2454. PMID: 30664268.

Citations: 20 Fields:
Gas Gastroenterology
Translation:Humans Animals
Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. PMID: 29272360.

Citations: 13 Fields:
End Endocrinology
Translation:Animals Cells
Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. Front Endocrinol (Lausanne). 2017; 8:23. PMID: 28239368.

Citations: 20 Fields:
End Endocrinology
Tsao J, Kovanecz I, Awadalla N, Gelfand R, Sinha-Hikim I, White RA, Gonzalez-Cadavid NF. Muscle Derived Stem Cells Stimulate Muscle Myofiber Repair and Counteract Fat Infiltration in a Diabetic Mouse Model of Critical Limb Ischemia. J Stem Cell Res Ther. 2016 Dec; 6(12). PMID: 28217409.

Citations:
Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata SK, Sinha-Hikim AP. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. PMID: 27917437.

Citations: 14 Fields:
Cel Cell Biology His Histology
Translation:Animals Cells
Sinha-Hikim I, Duran P, Shen R, Lee M, Friedman TC, Davidson MB. Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res. 2015 Apr; 47(4):280-3. PMID: 25011019.

Citations: 18 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Sinha I, Sinha-Hikim AP, Wagers AJ, Sinha-Hikim I. Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model. Cell Tissue Res. 2014 Sep; 357(3):815-21. PMID: 24859218.

Citations: 21 Fields:
Cel Cell Biology His Histology
Translation:Animals Cells
Ivey R, Desai M, Green K, Sinha-Hikim I, Friedman TC, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res. 2014 Jul; 46(8):568-73. PMID: 24830635.

Citations: 12 Fields:
End Endocrinology Met Metabolism
Translation:Animals Cells
Sinha-Hikim I, Friedman TC, Shin CS, Lee D, Ivey R, Sinha-Hikim AP. Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology. 2014 Mar; 155(3):865-72. PMID: 24424058.

Citations: 17 Fields:
End Endocrinology
Translation:Animals Cells
Sinha-Hikim I, Sinha-Hikim AP, Parveen M, Shen R, Goswami R, Tran P, Crum A, Norris KC. Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging. J Gerontol A Biol Sci Med Sci. 2013 Jul; 68(7):749-59. PMID: 23459206.

Citations: 26 Fields:
Ger Geriatrics
Translation:Animals
Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 2012 Dec; 153(12):5809-20. PMID: 23093702.

Citations: 31 Fields:
End Endocrinology
Translation:Animals Cells
Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26. PMID: 22138237.

Citations: 33 Fields:
End Endocrinology
Translation:Animals
Sinha-Hikim I, Shen R, Nzenwa I, Gelfand R, Mahata SK, Sinha-Hikim AP. Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis. 2011 Jun; 16(6):563-73. PMID: 21424555.

Citations: 20 Fields:
Cel Cell Biology
Translation:Humans Animals Cells PHPublic Health
Sinha-Hikim I, Sinha-Hikim AP, Shen R, Kim HJ, Kim H, French SW, Vaziri ND, Vaziri ND, Crum AC, Crum A, Rajavashisth TB, Norris KC. A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp Mol Pathol. 2011 Aug; 91(1):419-28. PMID: 21570964.

Citations: 24 Fields:
Mol Molecular Biology Pat Pathology
Translation:Animals Cells
Sinha-Hikim I, Shen R, Paul Lee WN, Crum A, Vaziri ND, Norris KC. Effects of a novel cystine-based glutathione precursor on oxidative stress in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C638-42. PMID: 20592243.

Citations: 14 Fields:
Cel Cell Biology Phy Physiology
Translation:Humans Cells
Sinha-Hikim I, Shen R, Kovacheva E, Crum A, Vaziri ND, Norris KC. Inhibition of apoptotic signalling in spermine-treated vascular smooth muscle cells by a novel glutathione precursor. Cell Biol Int. 2010 Apr 01; 34(5):503-11. PMID: 20121705.

Citations: 6 Fields:
Cel Cell Biology
Translation:Humans Cells
Kovacheva EL, Hikim AP, Shen R, Sinha I, Sinha-Hikim I. Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology. 2010 Feb; 151(2):628-38. PMID: 20022929.

Citations: 71 Fields:
End Endocrinology
Translation:Humans Animals Cells
Brown D, Hikim AP, Kovacheva EL, Sinha-Hikim I. Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling. J Endocrinol. 2009 Apr; 201(1):129-39. PMID: 19144735.

Citations: 20 Fields:
End Endocrinology
Translation:Animals Cells
Jia Y, Castellanos J, Wang C, Sinha-Hikim I, Lue Y, Swerdloff RS, Sinha-Hikim AP. Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biol Reprod. 2009 Apr; 80(4):771-80. PMID: 19109224.

Citations: 23 Fields:
Rep Reproductive Medicine
Translation:Animals Cells
Braga M, Sinha Hikim AP, Datta S, Ferrini MG, Brown D, Kovacheva EL, Gonzalez-Cadavid NF, Sinha-Hikim I. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis. 2008 Jun; 13(6):822-32. PMID: 18461459.

Citations: 63 Fields:
Cel Cell Biology
Translation:Animals Cells
Sinha-Hikim I, Braga M, Shen R, Sinha Hikim AP. Involvement of c-Jun NH2-terminal kinase and nitric oxide-mediated mitochondria-dependent intrinsic pathway signaling in cardiotoxin-induced muscle cell death: role of testosterone. Apoptosis. 2007 Nov; 12(11):1965-78. PMID: 17786558.

Citations: 19 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Herbst KL, Calof OM, Hsia SH, Sinha-Hikim I, Woodhouse LJ, Buchanan TA, Bhasin S. Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss. Fertil Steril. 2006 Jun; 85(6):1794-802. PMID: 16759927.

Citations: 6 Fields:
Rep Reproductive Medicine
Translation:Humans
Sinha-Hikim I, Cornford M, Gaytan H, Lee ML, Bhasin S. Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. J Clin Endocrinol Metab. 2006 Aug; 91(8):3024-33. PMID: 16705073.

Citations: 101 Fields:
End Endocrinology Met Metabolism
Translation:Humans Cells
Singh AB, Lee ML, Sinha-Hikim I, Kushnir M, Meikle W, Rockwood A, Afework S, Bhasin S. Pharmacokinetics of a testosterone gel in healthy postmenopausal women. J Clin Endocrinol Metab. 2006 Jan; 91(1):136-44. PMID: 16263817.

Citations: 10 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Gray PB, Singh AB, Woodhouse LJ, Storer TW, Casaburi R, Dzekov J, Dzekov C, Sinha-Hikim I, Bhasin S. Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men. J Clin Endocrinol Metab. 2005 Jul; 90(7):3838-46. PMID: 15827094.

Citations: 48 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Choi HH, Gray PB, Storer TW, Calof OM, Woodhouse L, Singh AB, Padero C, Mac RP, Sinha-Hikim I, Shen R, Dzekov J, Dzekov C, Kushnir MM, Rockwood AL, Meikle AW, Lee ML, Hays RD, Bhasin S. Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss. J Clin Endocrinol Metab. 2005 Mar; 90(3):1531-41. PMID: 15613414.

Citations: 22 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Bhasin S, Woodhouse L, Casaburi R, Singh AB, Mac RP, Lee M, Yarasheski KE, Sinha-Hikim I, Dzekov C, Dzekov J, Magliano L, Storer TW. Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab. 2005 Feb; 90(2):678-88. PMID: 15562020.

Citations: 153 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab. 2005 Feb; 90(2):855-63. PMID: 15522925.

Citations: 9 Fields:
End Endocrinology Met Metabolism
Translation:Humans Animals Cells
Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S. Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. J Clin Endocrinol Metab. 2004 Oct; 89(10):5245-55. PMID: 15472231.

Citations: 92 Fields:
End Endocrinology Met Metabolism
Translation:Humans Cells CTClinical Trials
Bhasin S, Taylor WE, Singh R, Artaza J, Sinha-Hikim I, Jasuja R, Choi H, Gonzalez-Cadavid NF. The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci. 2003 Dec; 58(12):M1103-10. PMID: 14684707.

Citations: 60 Fields:
Ger Geriatrics
Translation:Humans Cells
Reisz-Porszasz S, Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Hogue A, Fielder TJ, Gonzalez-Cadavid NF. Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E876-88. PMID: 12824080.

Citations: 114 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals
Sinha-Hikim I, Roth SM, Lee MI, Bhasin S. Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men. Am J Physiol Endocrinol Metab. 2003 Jul; 285(1):E197-205. PMID: 12670837.

Citations: 96 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Humans Cells CTClinical Trials
Schroeder ET, Singh A, Bhasin S, Storer TW, Azen C, Davidson T, Martinez C, Sinha-Hikim I, Jaque SV, Terk M, Sattler FR. Effects of an oral androgen on muscle and metabolism in older, community-dwelling men. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E120-8. PMID: 12388137.

Citations: 17 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Humans CTClinical Trials
Sinha-Hikim I, Artaza J, Woodhouse L, Gonzalez-Cadavid N, Singh AB, Lee MI, Storer TW, Casaburi R, Shen R, Bhasin S. Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. Am J Physiol Endocrinol Metab. 2002 Jul; 283(1):E154-64. PMID: 12067856.

Citations: 115 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Humans Cells CTClinical Trials
Singh AB, Hsia S, Alaupovic P, Sinha-Hikim I, Woodhouse L, Buchanan TA, Shen R, Bross R, Berman N, Bhasin S. The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men. J Clin Endocrinol Metab. 2002 Jan; 87(1):136-43. PMID: 11788637.

Citations: 47 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Yarasheski KE, Bhasin S, Sinha-Hikim I, Pak-Loduca J, Gonzalez-Cadavid NF. Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. J Nutr Health Aging. 2002; 6(5):343-8. PMID: 12474026.

Citations: 117 Fields:
Ger Geriatrics Nut Nutritional Sciences
Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab. 2001 Dec; 281(6):E1172-81. PMID: 11701431.

Citations: 222 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Humans CTClinical Trials
Singh AB, Norris K, Modi N, Sinha-Hikim I, Shen R, Davidson T, Bhasin S. Pharmacokinetics of a transdermal testosterone system in men with end stage renal disease receiving maintenance hemodialysis and healthy hypogonadal men. J Clin Endocrinol Metab. 2001 Jun; 86(6):2437-45. PMID: 11397836.

Citations: 15 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Javanbakht M, Singh AB, Mazer NA, Beall G, Sinha-Hikim I, Shen R, Bhasin S. Pharmacokinetics of a novel testosterone matrix transdermal system in healthy, premenopausal women and women infected with the human immunodeficiency virus. J Clin Endocrinol Metab. 2000 Jul; 85(7):2395-401. PMID: 10902784.

Citations: 3 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Bhasin S, Storer TW, Javanbakht M, Berman N, Yarasheski KE, Phillips J, Dike M, Sinha-Hikim I, Shen R, Hays RD, Beall G. Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. JAMA. 2000 Feb 09; 283(6):763-70. PMID: 10683055.

Citations: 70 Fields:
Med Medicine (General)
Translation:Humans CTClinical Trials
Zachwieja JJ, Smith SR, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration. J Gravit Physiol. 1999 Oct; 6(2):11-5. PMID: 11543081.

Citations: 19 Fields:
Phy Physiology
Translation:Humans
Arver S, Sinha-Hikim I, Beall G, Guerrero M, Shen R, Bhasin S. Serum dihydrotestosterone and testosterone concentrations in human immunodeficiency virus-infected men with and without weight loss. J Androl. 1999 Sep-Oct; 20(5):611-8. PMID: 10520573.

Citations: 10 Fields:
Rep Reproductive Medicine Uro Urology
Translation:Humans CTClinical Trials
Salehian B, Jacobson D, Swerdloff RS, Grafe MR, Sinha-Hikim I, McCutchan JA. Testicular pathologic changes and the pituitary-testicular axis during human immunodeficiency virus infection. Endocr Pract. 1999 Jan-Feb; 5(1):1-9. PMID: 15251696.

Citations: 3 Fields:
End Endocrinology
Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, Bhasin S. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14938-43. PMID: 9843994.

Citations: 146 Fields:
Sci Science
Translation:Humans Animals Cells
Bhasin S, Storer TW, Asbel-Sethi N, Kilbourne A, Hays R, Sinha-Hikim I, Shen R, Arver S, Beall G. Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels. J Clin Endocrinol Metab. 1998 Sep; 83(9):3155-62. PMID: 9745419.

Citations: 21 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Sinha-Hikim I, Arver S, Beall G, Shen R, Guerrero M, Sattler F, Shikuma C, Nelson JC, Landgren BM, Mazer NA, Bhasin S. The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab. 1998 Apr; 83(4):1312-8. PMID: 9543161.

Citations: 38 Fields:
End Endocrinology Met Metabolism
Translation:Humans Cells

Year	Publications
1998	3
1999	3
2000	2
2001	2
2002	4
2003	3
2004	4
2005	2
2006	2
2007	1
2008	2
2009	2
2010	2
2011	3
2012	1
2013	1
2014	4
2016	2
2017	1
2018	1
2019	1

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