Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Descriptor ID	D015395
MeSH Number(s)	D12.776.395.550.489 D12.776.543.550.439 D23.050.301.500.100 D23.050.705.552.100
Concept/Terms	Histocompatibility Antigens Class I Histocompatibility Antigens Class I Class I Histocompatibility Antigens Class I Antigens Antigens, Class I I Antigens, Class Class I Major Histocompatibility Antigens Human Class I Antigens Human Class I Antigens Class I Human Antigens

Below are MeSH descriptors whose meaning is more general than "Histocompatibility Antigens Class I".

Below are MeSH descriptors whose meaning is related to "Histocompatibility Antigens Class I".

Below are MeSH descriptors whose meaning is more specific than "Histocompatibility Antigens Class I".