Valproic Acid

"Valproic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.

Descriptor ID	D014635
MeSH Number(s)	D02.241.081.944.509.900 D10.251.400.895.593.900
Concept/Terms	Valproic Acid Valproic Acid Propylisopropylacetic Acid 2-Propylpentanoic Acid 2 Propylpentanoic Acid Divalproex Depakene Depakene Depakine Convulsofin Convulsofin Depakote Depakote Vupral Vupral Divalproex Sodium Divalproex Sodium Semisodium Valproate Valproic Acid, Sodium Salt (2:1) Ergenyl Ergenyl Magnesium Valproate Magnesium Valproate Valproate Valproate Valproate Sodium Valproate Sodium Sodium Valproate Valproate, Sodium Calcium Valproate Calcium Valproate Valproate, Calcium Valproate Calcium Dipropyl Acetate Dipropyl Acetate

Below are MeSH descriptors whose meaning is more general than "Valproic Acid".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Carboxylic Acids [D02.241]
Acids, Acyclic [D02.241.081]
Valerates [D02.241.081.944]
Pentanoic Acids [D02.241.081.944.509]
Valproic Acid [D02.241.081.944.509.900]
Lipids [D10]
Fatty Acids [D10.251]
Fatty Acids, Volatile [D10.251.400]
Valerates [D10.251.400.895]
Pentanoic Acids [D10.251.400.895.593]
Valproic Acid [D10.251.400.895.593.900]

Below are MeSH descriptors whose meaning is related to "Valproic Acid".

Below are MeSH descriptors whose meaning is more specific than "Valproic Acid".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Valproic Acid" by people in this website by year, and whether "Valproic Acid" was a major or minor topic of these publications.

Bar chart showing 14 publications over 10 distinct years, with a maximum of 3 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	1	1	2
2006	1	0	1
2011	1	0	1
2012	1	0	1
2016	1	2	3
2017	1	0	1
2018	1	0	1
2019	2	0	2
2024	0	1	1

Below are the most recent publications written about "Valproic Acid" by people in Profiles.

Csoka AB, El Kouhen N, Bennani S, Getachew B, Aschner M, Tizabi Y. Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder. Biomolecules. 2024 Apr 03; 14(4).

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Park A, Shapiro B, Hedayati B, Faziola L. Case of significantly delayed divalproex-induced thrombocytopaenia. BMJ Case Rep. 2019 Dec 02; 12(12).

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Patel K, Doddapaneni R, Patki M, Sekar V, Bagde A, Singh M. Erlotinib-Valproic Acid Liquisolid Formulation: Evaluating Oral Bioavailability and Cytotoxicity in Erlotinib-Resistant Non-small Cell Lung Cancer Cells. AAPS PharmSciTech. 2019 Mar 04; 20(3):135.

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Johnson J, Pajarillo E, Karki P, Kim J, Son DS, Aschner M, Lee E. Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. Neurotoxicology. 2018 07; 67:112-120.

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Johnson J, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. Neurotoxicology. 2018 01; 64:230-239.

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Pulliam SR, Pellom ST, Shanker A, Adunyah SE. Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine. 2016 08; 84:74-87.

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Torres-Hern?ndez BA, Col?n LR, Rosa-Falero C, Torrado A, Miscalichi N, Ort?z JG, Gonz?lez-Sep?lveda L, P?rez-R?os N, Su?rez-P?rez E, Bradsher JN, Behra M. Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract. Psychopharmacology (Berl). 2016 07; 233(13):2533-47.

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Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage FH, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe JR. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 05; 16:129.

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Ronaldson KJ, Fitzgerald PB, Taylor AJ, Topliss DJ, Wolfe R, McNeil JJ. Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: a case-control study. Schizophr Res. 2012 Nov; 141(2-3):173-8.

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Fortson WS, Kayarthodi S, Fujimura Y, Xu H, Matthews R, Grizzle WE, Rao VN, Bhat GK, Reddy ES. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J Oncol. 2011 Jul; 39(1):111-9.

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