Valproic Acid

"Valproic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.

Descriptor ID	D014635
MeSH Number(s)	D02.241.081.944.509.900 D10.251.400.895.593.900
Concept/Terms	Valproic Acid Valproic Acid Propylisopropylacetic Acid 2-Propylpentanoic Acid 2 Propylpentanoic Acid Divalproex Depakene Depakene Depakine Convulsofin Convulsofin Depakote Depakote Vupral Vupral Divalproex Sodium Divalproex Sodium Semisodium Valproate Valproic Acid, Sodium Salt (2:1) Ergenyl Ergenyl Magnesium Valproate Magnesium Valproate Valproate Valproate Valproate Sodium Valproate Sodium Sodium Valproate Valproate, Sodium Calcium Valproate Calcium Valproate Valproate, Calcium Valproate Calcium Dipropyl Acetate Dipropyl Acetate

Below are MeSH descriptors whose meaning is more general than "Valproic Acid".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Carboxylic Acids [D02.241]
Acids, Acyclic [D02.241.081]
Valerates [D02.241.081.944]
Pentanoic Acids [D02.241.081.944.509]
Valproic Acid [D02.241.081.944.509.900]
Lipids [D10]
Fatty Acids [D10.251]
Fatty Acids, Volatile [D10.251.400]
Valerates [D10.251.400.895]
Pentanoic Acids [D10.251.400.895.593]
Valproic Acid [D10.251.400.895.593.900]

Below are MeSH descriptors whose meaning is related to "Valproic Acid".

Below are MeSH descriptors whose meaning is more specific than "Valproic Acid".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Valproic Acid" by people in this website by year, and whether "Valproic Acid" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2016 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	1	0	1
2012	1	0	1
2016	1	1	2
2017	1	1	2
2018	1	0	1
2019	1	0	1
2024	0	1	1

Below are the most recent publications written about "Valproic Acid" by people in Profiles.

Csoka AB, El Kouhen N, Bennani S, Getachew B, Aschner M, Tizabi Y. Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder. Biomolecules. 2024 Apr 03; 14(4).

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Park A, Shapiro B, Hedayati B, Faziola L. Case of significantly delayed divalproex-induced thrombocytopaenia. BMJ Case Rep. 2019 Dec 02; 12(12).

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Johnson J, Pajarillo E, Karki P, Kim J, Son DS, Aschner M, Lee E. Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. Neurotoxicology. 2018 07; 67:112-120.

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Androsova G, Krause R, Borghei M, Wassenaar M, Auce P, Avbersek A, Becker F, Berghuis B, Campbell E, Coppola A, Francis B, Wolking S, Cavalleri GL, Craig J, Delanty N, Koeleman BPC, Kunz WS, Lerche H, Marson AG, Sander JW, Sills GJ, Striano P, Zara F, Sisodiya SM, Depondt C. Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia. 2017 10; 58(10):1734-1741.

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Johnson J, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. Neurotoxicology. 2018 01; 64:230-239.

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Pulliam SR, Pellom ST, Shanker A, Adunyah SE. Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine. 2016 08; 84:74-87.

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Torres-Hern?ndez BA, Col?n LR, Rosa-Falero C, Torrado A, Miscalichi N, Ort?z JG, Gonz?lez-Sep?lveda L, P?rez-R?os N, Su?rez-P?rez E, Bradsher JN, Behra M. Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract. Psychopharmacology (Berl). 2016 07; 233(13):2533-47.

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Ronaldson KJ, Fitzgerald PB, Taylor AJ, Topliss DJ, Wolfe R, McNeil JJ. Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: a case-control study. Schizophr Res. 2012 Nov; 141(2-3):173-8.

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Fortson WS, Kayarthodi S, Fujimura Y, Xu H, Matthews R, Grizzle WE, Rao VN, Bhat GK, Reddy ES. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J Oncol. 2011 Jul; 39(1):111-9.

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Kawai Y, Arinze IJ. Valproic acid-induced gene expression through production of reactive oxygen species. Cancer Res. 2006 Jul 01; 66(13):6563-9.

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