NF-E2-Related Factor 2

"NF-E2-Related Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.

Descriptor ID	D051267
MeSH Number(s)	D12.776.260.108.737 D12.776.930.127.737
Concept/Terms	NF-E2-Related Factor 2 NF-E2-Related Factor 2 NF E2 Related Factor 2 Nuclear Factor E2-Related Factor 2 Nuclear Factor E2 Related Factor 2 Nfe2l2 Protein Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein

Below are MeSH descriptors whose meaning is more general than "NF-E2-Related Factor 2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
NF-E2-Related Factor 2 [D12.776.260.108.737]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
NF-E2-Related Factor 2 [D12.776.930.127.737]

Below are MeSH descriptors whose meaning is related to "NF-E2-Related Factor 2".

Below are MeSH descriptors whose meaning is more specific than "NF-E2-Related Factor 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-E2-Related Factor 2" by people in this website by year, and whether "NF-E2-Related Factor 2" was a major or minor topic of these publications.

Bar chart showing 50 publications over 15 distinct years, with a maximum of 9 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2008	3	0	3
2009	1	0	1
2010	2	0	2
2011	2	1	3
2012	2	0	2
2013	3	1	4
2014	1	2	3
2015	5	0	5
2016	2	0	2
2017	1	0	1
2018	5	1	6
2019	3	0	3
2020	6	3	9
2021	2	3	5

Below are the most recent publications written about "NF-E2-Related Factor 2" by people in Profiles.

Awoyomi OV, Adeoye YD, Oyagbemi AA, Ajibade TO, Asenuga ER, Gbadamosi IT, Ogunpolu BS, Falayi OO, Hassan FO, Omobowale TO, Arojojoye OA, Ola-Davies OE, Saba AB, Adedapo AA, Oguntibeju OO, Yakubu MA. Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways. Environ Toxicol. 2021 Nov; 36(11):2146-2160.

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Thakur V, Alcoreza N, Delgado M, Joddar B, Chattopadhyay M. Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats. Biomolecules. 2021 04 13; 11(4).

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Walters TS, McIntosh DJ, Ingram SM, Tillery L, Motley ED, Arinze IJ, Misra S. SUMO-Modification of Human Nrf2 at K110 and K533 Regulates Its Nucleocytoplasmic Localization, Stability and Transcriptional Activity. Cell Physiol Biochem. 2021 Mar 27; 55(2):141-159.

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Sampath C, Wilus D, Tabatabai M, Freeman ML, Gangula PR. Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice. Biomed Pharmacother. 2021 May; 137:111370.

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Ghoneum MH, El Sayed NS. Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways. Oxid Med Cell Longev. 2021; 2021:8845064.

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Hilliard A, Mendonca P, Russell TD, Soliman KFA. The Protective Effects of Flavonoids in Cataract Formation through the Activation of Nrf2 and the Inhibition of MMP-9. Nutrients. 2020 Nov 27; 12(12).

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Sampath C, Okoro EU, Gipson MJ, Chukkapalli SS, Farmer-Dixon CM, Gangula PR. Porphyromonas gingivalis infection alters Nrf2-phase II enzymes and nitric oxide in primary human aortic endothelial cells. J Periodontol. 2021 07; 92(7):54-65.

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Sprouse J, Sampath C, Gangula PR. Role of sex hormones and their receptors on gastric Nrf2 and neuronal nitric oxide synthase function in an experimental hyperglycemia model. BMC Gastroenterol. 2020 Sep 23; 20(1):313.

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Oyagbemi AA, Adejumobi OA, Ajibade TO, Asenuga ER, Afolabi JM, Ogunpolu BS, Falayi OO, Hassan FO, Nabofa EW, Olutayo Omobowale T, Ola-Davies OE, Saba AB, Adedapo AA, Oguntibeju OO, Yakubu MA. Luteolin Attenuates Glycerol-Induced Acute Renal Failure and Cardiac Complications Through Modulation of Kim-1/NF-?B/Nrf2 Signaling Pathways. J Diet Suppl. 2021; 18(5):543-565.

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Bowman BM, Montgomery SA, Schrank TP, Simon JM, Ptacek TS, Tamir TY, Mulvaney KM, Weir SJ, Nguyen TT, Murphy RM, Makowski L, Hayes DN, Chen XL, Randell SH, Weissman BE, Major MB. A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. J Pathol. 2020 10; 252(2):125-137.

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