Amyloid beta-Protein Precursor

"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.

Descriptor ID	D016564
MeSH Number(s)	D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
Concept/Terms	Amyloid beta-Protein Precursor Amyloid beta-Protein Precursor Amyloid beta Protein Precursor beta-Protein Precursor, Amyloid Amyloid beta Precursor Protein Protease Nexin II Nexin II, Protease beta-Amyloid Protein Precursor beta Amyloid Protein Precursor Protease Nexin 2 Nexin 2, Protease Amyloid A4 Protein Precursor Amyloid Protein Precursor

Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Amyloid [D12.776.049]
Amyloidogenic Proteins [D12.776.049.407]
Amyloid beta-Protein Precursor [D12.776.049.407.249]
Membrane Proteins [D12.776.543]
Amyloid beta-Protein Precursor [D12.776.543.039]
Proteinase Inhibitory Proteins, Secretory [D12.776.645]
Protease Nexins [D12.776.645.468]
Amyloid beta-Protein Precursor [D12.776.645.468.500]
Protein Precursors [D12.776.811]
Amyloid beta-Protein Precursor [D12.776.811.050]

Below are MeSH descriptors whose meaning is related to "Amyloid beta-Protein Precursor".

Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".

Amyloid beta-Protein Precursor
Amyloid beta-Peptides

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.

Bar chart showing 70 publications over 26 distinct years, with a maximum of 6 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	3	1	4
1998	1	2	3
2000	1	0	1
2002	2	3	5
2003	0	5	5
2004	1	2	3
2005	1	1	2
2006	2	1	3
2007	4	2	6
2008	0	1	1
2009	3	2	5
2010	1	2	3
2011	3	2	5
2012	3	0	3
2013	1	0	1
2014	0	1	1
2015	1	2	3
2016	0	1	1
2017	2	3	5
2018	1	0	1
2019	3	0	3
2020	1	0	1
2021	0	2	2
2022	0	1	1
2024	0	1	1
2026	0	1	1

Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.

Garc?a-Carlos CA, Salas-Gallardo A, Gonz?lez-Pereyra P, Basurto-Islas G, Perry G, Mondrag?n-Rodr?guez S. Amyloid-? and phosphorylated-tau accumulation in retrosplenial cortex of young Alzheimer's disease model: Impact on network activity. J Alzheimers Dis. 2026 Mar; 110(2):576-587.

View in: PubMed
Zhong MZ, Peng T, Duarte ML, Wang M, Cai D. Updates on mouse models of Alzheimer's disease. Mol Neurodegener. 2024 Mar 11; 19(1):23.

View in: PubMed
Chaudry O, Ndukwe K, Xie L, Figueiredo-Pereira M, Serrano P, Rockwell P. Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats. Sci Rep. 2022 11 09; 12(1):19129.

View in: PubMed
Zayas-Santiago A, Mart?nez-Montemayor MM, Col?n-V?zquez J, Ortiz-Soto G, Cirino-Simonet JG, Inyushin M. Accumulation of amyloid beta (A?) and amyloid precursor protein (APP) in tumors formed by a mouse xenograft model of inflammatory breast cancer. FEBS Open Bio. 2022 01; 12(1):95-105.

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Peng Z, Bedi S, Mann V, Sundaresan A, Homma K, Gaskey G, Kowada M, Umar S, Kulkarni AD, Eltzschig HK, Doursout MF. Neuroprotective Effects of Asparagus officinalis Stem Extract in Transgenic Mice Overexpressing Amyloid Precursor Protein. J Immunol Res. 2021; 2021:8121407.

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Tan X, Liang Z, Li Y, Zhi Y, Yi L, Bai S, Forest KH, Nichols RA, Dong Y, Li QX. Isoorientin, a GSK-3? inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice. Behav Brain Res. 2021 02 01; 398:112968.

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Gao J, Wang L, Gao C, Arakawa H, Perry G, Wang X. TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2020 01 01; 1866(1):165580.

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Lai YJ, Zhu BL, Sun F, Luo D, Ma YL, Luo B, Tang J, Xiong MJ, Liu L, Long Y, Hu XT, He L, Deng XJ, Zhang JH, Yang J, Yan Z, Chen GJ. Estrogen receptor a promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging Cell. 2019 08; 18(4):e12961.

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Inyushin M, Zayas-Santiago A, Rojas L, Kucheryavykh Y, Kucheryavykh L. Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma. Histol Histopathol. 2019 Aug; 34(8):843-856.

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Kelley AR, Bach SBH, Perry G. Analysis of post-translational modifications in Alzheimer's disease by mass spectrometry. Biochim Biophys Acta Mol Basis Dis. 2019 08 01; 1865(8):2040-2047.

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