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Lilia Kucheryavykh

Titlebrain cancer researcher
Faculty RankAssistant Professor
InstitutionUniversidad Central Del Caribe
DepartmentBiochemistry
AddressCall box 60327
Bayamon PR 00960-6032
Phone(787) 798-3001 Ext. 2101
Fax787-786-6285
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    SC2GM102040     (KUCHERYAVYKH, LILIA)Sep 1, 2013 - Aug 31, 2017
    NIH
    Microglia promote dispersal of glioma cells through Pyk2 intracellular signaling
    Role: Principal Investigator
    SC1GM122691     (KUCHERYAVYKH, LILIA)Sep 1, 2017 - Aug 31, 2022
    NIH
    Microglia facilitate glioma progression through the Pyk2 and FAK signaling
    Role: Principal Investigator
    R15CA287203     (KUCHERYAVYKH, LILIA)Dec 1, 2023 - Nov 30, 2026
    NIH
    Pyk2 regulates extracellular vesicles release in GBM cells and modulates activation of tumor infiltrating myeloid cells
    Role: Principal Investigator
    R16GM153522     (KUCHERYAVYKH, LILIA)Apr 1, 2024 - Mar 31, 2028
    NIH
    Pyk2 inhibition mitigates immunosuppressive environment and enhances therapeutic response to immune checkpoint inhibitors in GBM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Porter T, Kucheryavykh L. F10 Gene Expression and Ethnic Disparities Present in Papillary Thyroid Carcinoma. J Pers Med. 2024 May 15; 14(5). PMID: 38793106.
      Citations:    
    2. Porter T, Del Valle MM, Kucheryavykh L. Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population. Int J Mol Sci. 2024 May 01; 25(9). PMID: 38732165.
      Citations:    Fields:    Translation:HumansCells
    3. Ortiz Rivera J, Velez Crespo G, Inyushin M, Kucheryavykh Y, Kucheryavykh L. Pyk2/FAK Signaling Is Upregulated in Recurrent Glioblastoma Tumors in a C57BL/6/GL261 Glioma Implantation Model. Int J Mol Sci. 2023 Aug 30; 24(17). PMID: 37686276.
      Citations: 1     Fields:    Translation:Animals
    4. Crespo GV, Ortiz J, O'Farrill EH, Vlaar CP, Inyushin M, Kucheryavykh Y, Kucheryavykh L. The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer. Mol Med. 2023 06 14; 29(1):75. PMID: 37316799.
      Citations:    Fields:    Translation:HumansAnimals
    5. Ortiz-Rivera J, Nu?ez R, Kucheryavykh Y, Kucheryavykh L. The PYK2 inhibitor PF-562271 enhances the effect of temozolomide on tumor growth in a C57Bl/6-Gl261 mouse glioma model. J Neurooncol. 2023 Feb; 161(3):593-604. PMID: 36790653.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Ortiz-Rivera J, Albors A, Kucheryavykh Y, Harrison JK, Kucheryavykh L. The Dynamics of Tumor-Infiltrating Myeloid Cell Activation and the Cytokine Expression Profile in a Glioma Resection Site during the Post-Surgical Period in Mice. Brain Sci. 2022 Jul 07; 12(7). PMID: 35884700.
      Citations:    
    7. Nu?ez RE, Del Valle MM, Ortiz K, Almodovar L, Kucheryavykh L. Microglial Cytokines Induce Invasiveness and Proliferation of Human Glioblastoma through Pyk2 and FAK Activation. Cancers (Basel). 2021 Dec 07; 13(24). PMID: 34944779.
      Citations:    
    8. Inyushin M, Zayas-Santiago A, Rojas L, Kucheryavykh L. On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications. Front Immunol. 2020; 11:571083. PMID: 33123145.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    9. Kucheryavykh LY, Ortiz-Rivera J, Kucheryavykh YV, Zayas-Santiago A, Diaz-Garcia A, Inyushin MY. Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors. Int J Mol Sci. 2019 May 20; 20(10). PMID: 31137462.
      Citations: 10     Fields:    Translation:AnimalsCells
    10. Kucheryavykh YV, Davila J, Ortiz-Rivera J, Inyushin M, Almodovar L, Mayol M, Morales-Cruz M, Cruz-Monta?ez A, Barcelo-Bovea V, Griebenow K, Kucheryavykh LY. Targeted Delivery of Nanoparticulate Cytochrome C into Glioma Cells Through the Proton-Coupled Folate Transporter. Biomolecules. 2019 04 18; 9(4). PMID: 31003476.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    11. Inyushin M, Zayas-Santiago A, Rojas L, Kucheryavykh Y, Kucheryavykh L. Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma. Histol Histopathol. 2019 Aug; 34(8):843-856. PMID: 30945258.
      Citations: 19     Fields:    Translation:HumansCells
    12. Valent?n-Guillama G, L?pez S, Kucheryavykh YV, Chorna NE, P?rez J, Ortiz-Rivera J, Inyushin M, Makarov V, Valent?n-Acevedo A, Quinones-Hinojosa A, Boukli N, Kucheryavykh LY. HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell. Cancers (Basel). 2018 Sep 01; 10(9). PMID: 30200472.
      Citations:    
    13. Kucheryavykh LY, Kucheryavykh YV, Washington AV, Inyushin MY. Amyloid Beta Peptide Is Released during Thrombosis in the Skin. Int J Mol Sci. 2018 06 08; 19(6). PMID: 29890636.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Inyushin MY, Sanabria P, Rojas L, Kucheryavykh Y, Kucheryavykh L. A? Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development. Biomed Res Int. 2017; 2017:3948360. PMID: 29018812.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    15. L?pez SN, Rodr?guez-Valent?n M, Rivera M, Rodr?guez M, Babu M, Cubano LA, Xiong H, Wang G, Kucheryavykh L, Boukli NM. HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma. Oncotarget. 2017 Sep 15; 8(40):68415-68438. PMID: 28978127.
      Citations: 4     Fields:    
    16. Kucheryavykh LY, Benedikt J, Cubano LA, Skatchkov SN, Bukauskas FF, Kucheryavykh YV. Polyamines preserve connexin 43-mediated gap junctional communication during intracellular hypercalcemia and acidosis. Neuroreport. 2017 Mar 01; 28(4):208-213. PMID: 28134630.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. Kucheryavykh LY, D?vila-Rodr?guez J, Rivera-Aponte DE, Zueva LV, Washington AV, Sanabria P, Inyushin MY. Platelets are responsible for the accumulation of ?-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis. Brain Res Bull. 2017 01; 128:98-105. PMID: 27908798.
      Citations: 27     Fields:    Translation:AnimalsCells
    18. Morales-Cruz M, Cruz-Monta?ez A, Figueroa CM, Gonz?lez-Robles T, Davila J, Inyushin M, Loza-Rosas SA, Molina AM, Mu?oz-Perez L, Kucheryavykh LY, Tinoco AD, Griebenow K. Combining Stimulus-Triggered Release and Active Targeting Strategies Improves Cytotoxicity of Cytochrome c Nanoparticles in Tumor Cells. Mol Pharm. 2016 08 01; 13(8):2844-54. PMID: 27283751.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    19. Rivera-Aponte DE, M?ndez-Gonz?lez MP, Rivera-Pag?n AF, Kucheryavykh YV, Kucheryavykh LY, Skatchkov SN, Eaton MJ. Hyperglycemia reduces functional expression of astrocytic Kir4.1 channels and glial glutamate uptake. Neuroscience. 2015 Dec 03; 310:216-23. PMID: 26404875.
      Citations: 13     Fields:    Translation:AnimalsCells
    20. Rol?n-Reyes K, Kucheryavykh YV, Cubano LA, Inyushin M, Skatchkov SN, Eaton MJ, Harrison JK, Kucheryavykh LY. Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PLoS One. 2015; 10(6):e0131059. PMID: 26098895.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    21. Rivera-Pag?n AF, Rivera-Aponte DE, Melnik-Mart?nez KV, Zayas-Santiago A, Kucheryavykh LY, Martins AH, Cubano LA, Skatchkov SN, Eaton MJ. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia. PLoS One. 2015; 10(4):e0125195. PMID: 25886567.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    22. Zueva L, Rivera Y, Kucheryavykh L, Skatchkov SN, Eaton MJ, Sanabria P, Inyushin M. Electron microscopy in rat brain slices reveals rapid accumulation of Cisplatin on ribosomes and other cellular components only in glia. Chemother Res Pract. 2014; 2014:174039. PMID: 25610648.
      Citations:    
    23. Kucheryavykh LY, Rol?n-Reyes K, Kucheryavykh YV, Skatchkov S, Eaton MJ, Sanabria P, Wessinger WD, Inyushin M. Glioblastoma development in mouse brain: general reduction of OCTs and mislocalization of OCT3 transporter and subsequent uptake of ASP+ substrate to the nuclei. J Neurosci Neuroeng. 2014 Feb; 3(1):3-9. PMID: 25165637.
      Citations:    
    24. Makarov V, Kucheryavykh L, Kucheryavykh Y, Rivera A, Eaton MJ, Skatchkov SN, Inyushin M. Transport Reversal during Heteroexchange: A Kinetic Study. J Biophys. 2013; 2013:683256. PMID: 24307897.
      Citations:    
    25. Benedikt J, Inyushin M, Kucheryavykh YV, Rivera Y, Kucheryavykh LY, Nichols CG, Eaton MJ, Skatchkov SN. Intracellular polyamines enhance astrocytic coupling. Neuroreport. 2012 Dec 05; 23(17):1021-5. PMID: 23076119.
      Citations: 30     Fields:    Translation:AnimalsCells
    26. Kucheryavykh LY, Kucheryavykh YV, Rol?n-Reyes K, Skatchkov SN, Eaton MJ, Cubano LA, Inyushin M. Visualization of implanted GL261 glioma cells in living mouse brain slices using fluorescent 4-(4-(dimethylamino)-styryl)-N-methylpyridinium iodide (ASP+). Biotechniques. 2012 Nov; 53(5):305-9. PMID: 23570046.
      Citations: 10     Fields:    Translation:HumansAnimals
    27. Inyushin MY, Huertas A, Kucheryavykh YV, Kucheryavykh LY, Tsydzik V, Sanabria P, Eaton MJ, Skatchkov SN, Rojas LV, Wessinger WD. L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain. Parkinsons Dis. 2012; 2012:321406. PMID: 22888467.
      Citations:    
    28. Inyushin M, Kucheryavykh LY, Kucheryavykh YV, Nichols CG, Buono RJ, Ferraro TN, Skatchkov SN, Eaton MJ. Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. Epilepsia. 2010 Sep; 51(9):1707-13. PMID: 20831751.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    29. Sala-Rabanal M, Kucheryavykh LY, Skatchkov SN, Eaton MJ, Nichols CG. Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10). J Biol Chem. 2010 Nov 12; 285(46):36040-8. PMID: 20807765.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    30. Inyushin M, Kucheryaykh Y, Kucheryavykh L, Sanabria P, Jim?nez-Rivera C, Struganova I, Eaton M, Skatchkov S. Membrane potential and pH-dependent accumulation of decynium-22 (1,1'-diethyl-2,2'-cyanine iodide) flourencence through OCT transporters in astrocytes. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):5-12. PMID: 23875515.
      Citations: 9     Fields:    Translation:AnimalsCells
    31. Kucheryavykh LY, Kucheryavykh YV, Inyushin M, Shuba YM, Sanabria P, Cubano LA, Skatchkov SN, Eaton MJ. Ischemia Increases TREK-2 Channel Expression in Astrocytes: Relevance to Glutamate Clearance. Open Neurosci J. 2009 Jan 01; 3:40-47. PMID: 19890471.
      Citations:    
    32. Kucheryavykh YV, Kucheryavykh LY, Nichols CG, Maldonado HM, Baksi K, Reichenbach A, Skatchkov SN, Eaton MJ. Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes. Glia. 2007 Feb; 55(3):274-81. PMID: 17091490.
      Citations: 126     Fields:    Translation:AnimalsCells
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