"Focal Adhesion Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.
| Descriptor ID |
D051418
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.049.750 D23.050.301.500.600.350 D23.050.705.552.600.350
|
| Concept/Terms |
Focal Adhesion Kinase 2- Focal Adhesion Kinase 2
- RAFTK Protein
- Cell Adhesion Kinase Beta
- Proline-Rich Tyrosine Kinase 2
- Proline Rich Tyrosine Kinase 2
- Related Adhesion Focal Tyrosine Kinase
- CADTK Protein
- Focal Adhesion Kinase Autokinase
- FAK Autokinase
- Calcium-Dependent Protein Tyrosine Kinase
- Calcium Dependent Protein Tyrosine Kinase
- PYK2 Protein Tyrosine Kinase
- Protein Tyrosine Kinase PYK2
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 2".
This graph shows the total number of publications written about "Focal Adhesion Kinase 2" by people in this website by year, and whether "Focal Adhesion Kinase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2023 | 0 | 3 | 3 |
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Below are the most recent publications written about "Focal Adhesion Kinase 2" by people in Profiles.
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Ortiz Rivera J, Velez Crespo G, Inyushin M, Kucheryavykh Y, Kucheryavykh L. Pyk2/FAK Signaling Is Upregulated in Recurrent Glioblastoma Tumors in a C57BL/6/GL261 Glioma Implantation Model. Int J Mol Sci. 2023 Aug 30; 24(17).
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Crespo GV, Ortiz J, O'Farrill EH, Vlaar CP, Inyushin M, Kucheryavykh Y, Kucheryavykh L. The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer. Mol Med. 2023 06 14; 29(1):75.
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Ortiz-Rivera J, Nu?ez R, Kucheryavykh Y, Kucheryavykh L. The PYK2 inhibitor PF-562271 enhances the effect of temozolomide on tumor growth in a C57Bl/6-Gl261 mouse glioma model. J Neurooncol. 2023 Feb; 161(3):593-604.
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Rol?n-Reyes K, Kucheryavykh YV, Cubano LA, Inyushin M, Skatchkov SN, Eaton MJ, Harrison JK, Kucheryavykh LY. Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PLoS One. 2015; 10(6):e0131059.
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Tsao CW, Lin CF, Wu HT, Ma CT, Huang WC, Hsieh CY, Choi PC, Young KC. Glycogen synthase kinase-3? is critical for interferon-a-induced serotonin uptake in human Jurkat T cells. J Cell Physiol. 2012 Jun; 227(6):2556-66.
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Tarzami ST, Hsieh SS, Esterman MA, Singh JP. Staurosporine promotes endothelial cell assembly and FAK phosphorylation during in vitro angiogenesis. J Cardiovasc Pharmacol. 2005 Jan; 45(1):22-9.
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Khan AM, Cheung HH, Gillard ER, Palarca JA, Welsbie DS, Gurd JW, Stanley BG. Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. J Neurosci. 2004 Nov 24; 24(47):10603-15.