Transforming Growth Factor beta
"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
| Descriptor ID |
D016212
|
| MeSH Number(s) |
D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
|
| Concept/Terms |
Transforming Growth Factor beta- Transforming Growth Factor beta
- Milk Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- TGF-beta
- TGFbeta
- Platelet Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Bone Derived Transforming Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".
This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 1 | 1 | 2 |
| 1996 | 1 | 1 | 2 |
| 1997 | 2 | 0 | 2 |
| 1998 | 3 | 1 | 4 |
| 1999 | 4 | 4 | 8 |
| 2000 | 2 | 2 | 4 |
| 2001 | 3 | 1 | 4 |
| 2002 | 3 | 3 | 6 |
| 2003 | 7 | 4 | 11 |
| 2004 | 4 | 2 | 6 |
| 2005 | 2 | 3 | 5 |
| 2006 | 6 | 2 | 8 |
| 2007 | 5 | 1 | 6 |
| 2008 | 6 | 3 | 9 |
| 2009 | 2 | 0 | 2 |
| 2010 | 3 | 1 | 4 |
| 2011 | 6 | 1 | 7 |
| 2012 | 4 | 3 | 7 |
| 2013 | 3 | 3 | 6 |
| 2014 | 2 | 2 | 4 |
| 2015 | 2 | 2 | 4 |
| 2016 | 4 | 3 | 7 |
| 2017 | 5 | 3 | 8 |
| 2018 | 0 | 3 | 3 |
| 2020 | 1 | 2 | 3 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 4 | 5 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.
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Callan A, Jha S, Valdez L, Baldado L, Tsin A. TGF-? Signaling Pathways in the Development of Diabetic Retinopathy. Int J Mol Sci. 2024 Mar 06; 25(5).
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Eni-Aganga I, Lanaghan ZM, Ismail F, Korolkova O, Goodwin JS, Balasubramaniam M, Dash C, Pandhare J. KLF6 activates Sp1-mediated prolidase transcription during TGF-?1 signaling. J Biol Chem. 2024 Feb; 300(2):105605.
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Deng S, Jin P, Liu S, He Y, Sherchan P, Zhang JH, Gong Y, Tang J. Recruitment of regulatory T cells with rCCL17 promotes M2 microglia/macrophage polarization through TGF?/TGF?R/Smad2/3 pathway in a mouse model of intracerebral hemorrhage. Exp Neurol. 2023 09; 367:114451.
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Lin X, Ahmad A, Ivanov AI, Simhadri J, Wang S, Kumari N, Ammosova T, Nekhai S. HIV-1 Transcription Inhibitor 1E7-03 Decreases Nucleophosmin Phosphorylation. Mol Cell Proteomics. 2023 02; 22(2):100488.
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Beaven E, Kumar R, Bhatt HN, Esquivel SV, Nurunnabi M. Myofibroblast specific targeting approaches to improve fibrosis treatment. Chem Commun (Camb). 2022 Dec 08; 58(98):13556-13571.
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Cobb MS, Tao S, Shortt K, Girgis M, Hauptman J, Schriewer J, Chin Z, Dorfman E, Campbell K, Heruth DP, Shohet RV, Dawn B, Konorev EA. Smad3 promotes adverse cardiovascular remodeling and dysfunction in doxorubicin-treated hearts. Am J Physiol Heart Circ Physiol. 2022 12 01; 323(6):H1091-H1107.
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Kong X, Yan K, Deng P, Fu H, Sun H, Huang W, Jiang S, Dai J, Zhang QC, Liu JG, Xi Q. LncRNA-Smad7 mediates cross-talk between Nodal/TGF-? and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells. Nucleic Acids Res. 2022 10 14; 50(18):10526-10543.
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Olokpa E, Mandape SN, Pratap S, Stewart MV. Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells. BMC Cancer. 2022 Sep 29; 22(1):1025.
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Chakraborty S, Utter MB, Frias MA, Foster DA. Cancer cells with defective RB and CDKN2A are resistant to the apoptotic effects of rapamycin. Cancer Lett. 2021 12 01; 522:164-170.
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Messeha SS, Zarmouh NO, Soliman KFA. Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer. Nutrients. 2021 May 19; 13(5).