Interleukin 1 Receptor Antagonist Protein

"Interleukin 1 Receptor Antagonist Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.

Descriptor ID	D053590
MeSH Number(s)	D12.644.276.374.460 D12.776.467.374.460 D23.529.374.460
Concept/Terms	Interleukin 1 Receptor Antagonist Protein Interleukin 1 Receptor Antagonist Protein IL1 Febrile Inhibitor Febrile Inhibitor, IL1 IL-1Ra Urine-Derived IL1 Inhibitor IL1 Inhibitor, Urine-Derived Urine Derived IL1 Inhibitor IL-1 Inhibitor, Urine IL 1 Inhibitor, Urine Urine IL-1 Inhibitor Interleukin 1 Inhibitor, Urine Antril Antril Kineret Kineret Anakinra Anakinra

Below are MeSH descriptors whose meaning is more general than "Interleukin 1 Receptor Antagonist Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukin 1 Receptor Antagonist Protein [D12.644.276.374.460]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukin 1 Receptor Antagonist Protein [D12.776.467.374.460]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukin 1 Receptor Antagonist Protein [D23.529.374.460]

Below are MeSH descriptors whose meaning is related to "Interleukin 1 Receptor Antagonist Protein".

Below are MeSH descriptors whose meaning is more specific than "Interleukin 1 Receptor Antagonist Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin 1 Receptor Antagonist Protein" by people in this website by year, and whether "Interleukin 1 Receptor Antagonist Protein" was a major or minor topic of these publications.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2006	1	1	2
2007	0	1	1
2010	1	0	1
2014	1	0	1
2015	0	1	1
2016	1	0	1
2020	1	0	1
2021	0	1	1

Below are the most recent publications written about "Interleukin 1 Receptor Antagonist Protein" by people in Profiles.

Porritt RA, Chase Huizar C, Dick EJ, Kumar S, Escalona R, Gomez AC, Marek-Iannucci S, Noval Rivas M, Patterson J, Forsthuber TG, Arditi M, Gorelik M. Inhibition of IL-6 in the LCWE Mouse Model of Kawasaki Disease Inhibits Acute Phase Reactant Serum Amyloid A but Fails to Attenuate Vasculitis. Front Immunol. 2021; 12:630196.

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Shi L, Song L, Maurer K, Dou Y, Patel VR, Su C, Leonard ME, Lu S, Hodge KM, Torres A, Chesi A, Grant SFA, Wells AD, Zhang Z, Petri MA, Sullivan KE. IL-1 Transcriptional Responses to Lipopolysaccharides Are Regulated by a Complex of RNA Binding Proteins. J Immunol. 2020 03 01; 204(5):1334-1344.

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Watanabe K, Uchida K, Chambers JK, Ushio N, Nakayama H. Deposition, Clearance, and Reinduction of Amyloid A Amyloid in Interleukin 1 Receptor Antagonist Knockout Mice. Vet Pathol. 2017 01; 54(1):99-110.

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Maphis N, Xu G, Kokiko-Cochran ON, Jiang S, Cardona A, Ransohoff RM, Lamb BT, Bhaskar K. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain. 2015 Jun; 138(Pt 6):1738-55.

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Watanabe K, Uchida K, Chambers JK, Tei M, Shoji A, Ushio N, Nakayama H. Experimental transmission of AA amyloidosis by injecting the AA amyloid protein into interleukin-1 receptor antagonist knockout (IL-1raKO) mice. Vet Pathol. 2015 May; 52(3):505-12.

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Rivera-Amill V, Kumar R, Noel RJ, Garcia Y, Rodriguez IV, Martinez M, Sariol CA, Kraiselburd E, Iszard M, Mukherji M, Kumar S, Giavedoni LD, Kumar A. Short communication: Lack of immune response in rapid progressor morphine-dependent and SIV/SHIV-infected rhesus macaques is correlated with downregulation of TH1 cytokines. AIDS Res Hum Retroviruses. 2010 Aug; 26(8):919-22.

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Armah HB, Wilson NO, Sarfo BY, Powell MD, Bond VC, Anderson W, Adjei AA, Gyasi RK, Tettey Y, Wiredu EK, Tongren JE, Udhayakumar V, Stiles JK. Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. Malar J. 2007 Nov 12; 6:147.

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Kamangar F, Cheng C, Abnet CC, Rabkin CS. Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1920-8.

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Nieman DC, Henson DA, Davis JM, Dumke CL, Utter AC, Murphy EA, Pearce S, Gojanovich G, McAnulty SR, McAnulty LS. Blood leukocyte mRNA expression for IL-10, IL-1Ra, and IL-8, but not IL-6, increases after exercise. J Interferon Cytokine Res. 2006 Sep; 26(9):668-74.

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Hu X, Nesic-Taylor O, Qiu J, Rea HC, Fabian R, Rassin DK, Perez-Polo JR. Activation of nuclear factor-kappaB signaling pathway by interleukin-1 after hypoxia/ischemia in neonatal rat hippocampus and cortex. J Neurochem. 2005 Apr; 93(1):26-37.

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