Leukemia Inhibitory Factor
"Leukemia Inhibitory Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An INTERLEUKIN-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. Leukemia inhibitory factor binds to and acts through the lif receptor.
| Descriptor ID |
D053605
|
| MeSH Number(s) |
D12.644.276.374.470 D12.776.467.374.470 D23.529.374.470
|
| Concept/Terms |
Leukemia Inhibitory Factor- Leukemia Inhibitory Factor
- Inhibitory Factor, Leukemia
- Differentiation-Stimulating Factor
- Differentiation Stimulating Factor
- D Factor (Leukemia Inhibitory Factor)
- Myeloid Differentiation-Stimulating Factor
- Differentiation-Stimulating Factor, Myeloid
- Myeloid Differentiation Stimulating Factor
- Cholinergic Differentiation Factor
- Differentiation Factor, Cholinergic
|
Below are MeSH descriptors whose meaning is more general than "Leukemia Inhibitory Factor".
Below are MeSH descriptors whose meaning is more specific than "Leukemia Inhibitory Factor".
This graph shows the total number of publications written about "Leukemia Inhibitory Factor" by people in this website by year, and whether "Leukemia Inhibitory Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
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Below are the most recent publications written about "Leukemia Inhibitory Factor" by people in Profiles.
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Taylor T, Kim YJ, Ou X, Derbigny W, Broxmeyer HE. Toll-like receptor 2 mediates proliferation, survival, NF-kappaB translocation, and cytokine mRNA expression in LIF-maintained mouse embryonic stem cells. Stem Cells Dev. 2010 Sep; 19(9):1333-41.
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Wang H, Yang Y, Sharma N, Tarasova NI, Timofeeva OA, Winkler-Pickett RT, Tanigawa S, Perantoni AO. STAT1 activation regulates proliferation and differentiation of renal progenitors. Cell Signal. 2010 Nov; 22(11):1717-26.
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Nowell MA, Richards PJ, Fielding CA, Ognjanovic S, Topley N, Williams AS, Bryant-Greenwood G, Jones SA. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 2006 Jul; 54(7):2084-95.
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Jenab S, Quinones-Jenab V. The effects of interleukin-6, leukemia inhibitory factor and interferon-gamma on STAT DNA binding and c-fos mRNA levels in cortical astrocytes and C6 glioma cells. Neuro Endocrinol Lett. 2002 Aug; 23(4):325-8.
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Jenab S, Morris PL. Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ cells. Endocrinology. 1998 Apr; 139(4):1883-90.