Osteopontin

"Osteopontin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.

Descriptor ID	D053495
MeSH Number(s)	D12.644.276.374.625 D12.776.395.700.837 D12.776.467.374.625 D12.776.860.300.762 D23.529.374.625
Concept/Terms	Osteopontin Osteopontin Sialoprotein 1 Secreted Phosphoprotein 1 Bone Sialoprotein 1 Sialoprotein 1, Bone Bone Sialoprotein I Sialoprotein I, Bone Uropontin Uropontin

Below are MeSH descriptors whose meaning is more general than "Osteopontin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Osteopontin [D12.644.276.374.625]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Sialoglycoproteins [D12.776.395.700]
Osteopontin [D12.776.395.700.837]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Osteopontin [D12.776.467.374.625]
Scleroproteins [D12.776.860]
Extracellular Matrix Proteins [D12.776.860.300]
Osteopontin [D12.776.860.300.762]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Osteopontin [D23.529.374.625]

Below are MeSH descriptors whose meaning is related to "Osteopontin".

Below are MeSH descriptors whose meaning is more specific than "Osteopontin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Osteopontin" by people in this website by year, and whether "Osteopontin" was a major or minor topic of these publications.

Bar chart showing 32 publications over 18 distinct years, with a maximum of 3 publications in 2011 and 2013 and 2014 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2004	0	1	1
2005	0	2	2
2007	1	1	2
2008	1	0	1
2009	0	1	1
2010	2	0	2
2011	3	0	3
2012	0	1	1
2013	2	1	3
2014	2	1	3
2015	0	1	1
2016	0	3	3
2017	0	2	2
2018	1	0	1
2019	1	1	2
2022	0	1	1
2023	1	1	2

Below are the most recent publications written about "Osteopontin" by people in Profiles.

Sun C, Rahman MSU, Enkhjargal B, Peng J, Zhou K, Xie Z, Wu L, Zhang T, Zhu Q, Tang J, Zeng Y, Zhang JH, Xu S. Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats. Exp Neurol. 2024 01; 371:114585.

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Sun L, Wu Y, Sinha SK, Nicholas SB, Zou LX. Performance of multi-biomarker panels based on urinary N-terminal osteopontin for prediction of diabetic kidney disease in patients with diabetes mellitus. Eur J Intern Med. 2023 12; 118:140-142.

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Messex JK, Byrd CJ, Thomas MU, Liou GY. Macrophages Cytokine Spp1 Increases Growth of Prostate Intraepithelial Neoplasia to Promote Prostate Tumor Progression. Int J Mol Sci. 2022 Apr 12; 23(8).

View in: PubMed
Sun CM, Enkhjargal B, Reis C, Zhou KR, Xie ZY, Wu LY, Zhang TY, Zhu QQ, Tang JP, Jiang XD, Zhang JH. Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats. CNS Neurosci Ther. 2019 10; 25(10):1162-1172.

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Zhao X, Chen X, Zhang Y, George J, Cobbs A, Wang G, Li L, Emmett N. Kidney Injury Molecule-1 Is Upregulated in Renal Lipotoxicity and Mediates Palmitate-Induced Tubular Cell Injury and Inflammatory Response. Int J Mol Sci. 2019 Jul 11; 20(14).

View in: PubMed
Augello CJ, Noll JM, Distel TJ, Wainright JD, Stout CE, Ford BD. Identification of novel blood biomarker panels to detect ischemic stroke in patients and their responsiveness to therapeutic intervention. Brain Res. 2018 11 01; 1698:161-169.

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Gong L, Manaenko A, Fan R, Huang L, Enkhjargal B, McBride D, Ding Y, Tang J, Xiao X, Zhang JH. Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage. Neuropharmacology. 2018 08; 138:160-169.

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Enkhjargal B, Malaguit J, Ho WM, Jiang W, Wan W, Wang G, Tang J, Zhang JH. Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats. J Cereb Blood Flow Metab. 2019 02; 39(2):272-284.

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Shanker A, Thounaojam MC, Mishra MK, Dikov MM. Innate-Adaptive Immune Crosstalk 2016. J Immunol Res. 2017; 2017:3503207.

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Wagner PJ, Park HR, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children. Environ Health Perspect. 2017 04; 125(4):721-729.

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