Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.

Behbod F, Erwin-Cohen RA, Wang ME, Trawick BW, Qu X, Verani R, Kahan BD, Stepkowski SM, Kirken RA. Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts. J Immunol. 2001 Mar 15; 166(6):3724-32.

View in: PubMed

subject areas

Animals
Calcineurin
Cell Division
Cell Line
Cell Movement
Cell Nucleus
Cells, Cultured
DNA
DNA-Binding Proteins
Enzyme Activation
Enzyme Inhibitors
Graft Enhancement, Immunologic
Graft Survival
Heart Transplantation
Humans
Immunosuppressive Agents
Injections, Intraperitoneal
Interleukin-2
Janus Kinase 3
Leukocytes, Mononuclear
Milk Proteins
Phosphorylation
Protein Binding
Protein-Tyrosine Kinases
Rats
Rats, Inbred ACI
Rats, Inbred Lew
Receptors, Interleukin-2
Serine
Signal Transduction
STAT5 Transcription Factor
T-Lymphocytes
Trans-Activators
Tumor Suppressor Proteins
Tyrosine
Tyrphostins

authors with profiles

Robert Kirken

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

For technical support please contact support