"Lac Repressors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Bacterial repressor proteins that bind to the LAC OPERON and thereby prevent the synthesis of proteins involved in catabolism of LACTOSE. When lactose levels are high lac repressors undergo an allosteric change that causes their release from the DNA and the resumption of lac operon transcription.
| Descriptor ID |
D056968
|
| MeSH Number(s) |
D12.776.097.521 D12.776.260.703.600 D12.776.930.780.781
|
| Concept/Terms |
Lac Repressors- Lac Repressors
- Repressors, Lac
- LacI Proteins
- Proteins, LacI
- Lac Repressor
- Repressor, Lac
|
Below are MeSH descriptors whose meaning is more general than "Lac Repressors".
Below are MeSH descriptors whose meaning is more specific than "Lac Repressors".
This graph shows the total number of publications written about "Lac Repressors" by people in this website by year, and whether "Lac Repressors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lac Repressors" by people in Profiles.
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Murphey P, McLean DJ, McMahan CA, Walter CA, McCarrey JR. Enhanced genetic integrity in mouse germ cells. Biol Reprod. 2013 Jan; 88(1):6.
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Caperton L, Murphey P, Yamazaki Y, McMahan CA, Walter CA, Yanagimachi R, McCarrey JR. Assisted reproductive technologies do not alter mutation frequency or spectrum. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5085-90.
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Lawley TD, Taylor DE. Characterization of the double-partitioning modules of R27: correlating plasmid stability with plasmid localization. J Bacteriol. 2003 May; 185(10):3060-7.
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Jarrett HW. Temperature dependence of DNA affinity chromatography of transcription factors. Anal Biochem. 2000 Mar 15; 279(2):209-17.
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Robinson FD, Gadgil H, Jarrett HW. Comparative studies on chemically and enzymatically coupled DNA-Sepharose columns for purification of a lac repressor chimeric fusion protein. J Chromatogr A. 1999 Jul 23; 849(2):403-12.
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Gadgil H, Jarrett HW. Heparin elution of transcription factors from DNA-Sepharose columns. J Chromatogr A. 1999 Jul 02; 848(1-2):131-8.
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Walter CA, Intano GW, McCarrey JR, McMahan CA, Walter RB. Mutation frequency declines during spermatogenesis in young mice but increases in old mice. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10015-9.