"DNA Topoisomerase IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
| Descriptor ID |
D027101
|
| MeSH Number(s) |
D08.811.399.403.741.224 D12.776.097.256
|
| Concept/Terms |
parC Protein- parC Protein
- parC Gene Product, Topo IV
- Topoisomerase IV Subunit A
- parC Gene Product
parE Protein- parE Protein
- parE Gene Product, Topo IV
- Topoisomerase IV Subunit B
- parE Gene Product
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerase IV".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerase IV".
This graph shows the total number of publications written about "DNA Topoisomerase IV" by people in this website by year, and whether "DNA Topoisomerase IV" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Topoisomerase IV" by people in Profiles.
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Medalla F, Sj?lund-Karlsson M, Shin S, Harvey E, Joyce K, Theobald L, Nygren BN, Pecic G, Gay K, Austin J, Stuart A, Blanton E, Mintz ED, Whichard JM, Barzilay EJ. Ciprofloxacin-resistant Salmonella enterica Serotype Typhi, United States, 1999-2008. Emerg Infect Dis. 2011 Jun; 17(6):1095-8.
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Zheng X, Johnson C, Lu Y, Yanagihara R, Hollingshead S, Crain M, Benjamin W, Waites KB. Clinical isolates of Streptococcus pneumoniae resistant to levofloxacin contain mutations in both gyrA and parC genes. Int J Antimicrob Agents. 2001 Oct; 18(4):373-8.