"Tetanus Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
| Descriptor ID |
D013744
|
| MeSH Number(s) |
D12.776.097.872 D23.946.123.893
|
| Concept/Terms |
Tetanus Toxin- Tetanus Toxin
- Toxin, Tetanus
- Clostridium tetani Toxin
- Toxin, Clostridium tetani
- Tetanus Toxins
- Toxins, Tetanus
|
Below are MeSH descriptors whose meaning is more general than "Tetanus Toxin".
Below are MeSH descriptors whose meaning is more specific than "Tetanus Toxin".
This graph shows the total number of publications written about "Tetanus Toxin" by people in this website by year, and whether "Tetanus Toxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tetanus Toxin" by people in Profiles.
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Getachew B, Mendieta L, Csoka AB, Aguilera J, Tizabi Y. Antidepressant effects of C-Terminal domain of the heavy chain of tetanus toxin in a rat model of depression. Behav Brain Res. 2019 09 16; 370:111968.
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McCarthy PC, Saksena R, Peterson DC, Lee CH, An Y, Cipollo JF, Vann WF. Chemoenzymatic synthesis of immunogenic meningococcal group C polysialic acid-tetanus Hc fragment glycoconjugates. Glycoconj J. 2013 Dec; 30(9):857-70.
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Hazra A, Silva AJ, Benitez JA. Expression of foreign proteins in a Vibrio cholerae vaccine strain using the stationary phase hemagglutinin/protease promoter. Biotechnol Lett. 2007 Jul; 29(7):1093-7.
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Karvar S, Yao X, Duman JG, Hybiske K, Liu Y, Forte JG. Intracellular distribution and functional importance of vesicle-associated membrane protein 2 in gastric parietal cells. Gastroenterology. 2002 Jul; 123(1):281-90.