"Complement Factor I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
| Descriptor ID |
D017244
|
| MeSH Number(s) |
D08.811.277.656.300.760.210 D08.811.277.656.959.350.210 D12.776.124.486.274.920.325.210
|
| Concept/Terms |
Complement Factor I- Complement Factor I
- C4b-C3b-INA
- C4b C3b INA
- C3b Inactivator
- Inactivator, C3b
- C4bC3bINA
- Complement C4b-C3b Inactivator
- C4b-C3b Inactivator, Complement
- Complement C4b C3b Inactivator
- Inactivator, Complement C4b-C3b
- C3b-C4b Inactivator
- C3b C4b Inactivator
- Inactivator, C3b-C4b
- Complement 3b-Complement 4b Inactivator
- Complement 3b Complement 4b Inactivator
|
Below are MeSH descriptors whose meaning is more general than "Complement Factor I".
Below are MeSH descriptors whose meaning is more specific than "Complement Factor I".
This graph shows the total number of publications written about "Complement Factor I" by people in this website by year, and whether "Complement Factor I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement Factor I" by people in Profiles.
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Reid W, Baas L, Stiegler AL, Boggon TJ, Kreiger PA, Sullivan KE, Behrens EM, Kandula VVR, van den Heuvel LP, Brigatti KW, Carson VJ, Romberg N. Complement factor I deficiency-associated neuroinflammatory disease among Old Order Amish. J Allergy Clin Immunol. 2025 Sep; 156(3):835-841.