Interleukin-8

"Interleukin-8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.

Descriptor ID	D016209
MeSH Number(s)	D12.644.276.374.200.120.800 D12.644.276.374.465.312 D12.776.467.374.200.120.800 D12.776.467.374.465.246 D23.125.300.120.800 D23.469.200.120.800 D23.529.374.200.120.800 D23.529.374.465.312
Concept/Terms	Interleukin-8 Interleukin-8 Interleukin 8 IL8 Monocyte-Derived Neutrophil Chemotactic Factor Neutrophil Activation Factor Neutrophil-Activating Peptide, Lymphocyte-Derived Lymphocyte-Derived Neutrophil-Activating Peptide Neutrophil Activating Peptide, Lymphocyte Derived Neutrophil-Activating Peptide, Monocyte-Derived Monocyte-Derived Neutrophil-Activating Peptide Neutrophil Activating Peptide, Monocyte Derived Alveolar Macrophage Chemotactic Factor-I Alveolar Macrophage Chemotactic Factor I AMCF-I Anionic Neutrophil-Activating Peptide Anionic Neutrophil Activating Peptide Neutrophil-Activating Peptide, Anionic Peptide, Anionic Neutrophil-Activating Chemokine CXCL8 CXCL8, Chemokine Chemokines, CXCL8 CXCL8 Chemokines Chemotactic Factor, Macrophage-Derived Chemotactic Factor, Macrophage Derived Macrophage-Derived Chemotactic Factor Chemotactic Factor, Neutrophil Neutrophil Chemotactic Factor Chemotactic Factor, Neutrophil, Monocyte-Derived CXCL8 Chemokine Chemokine, CXCL8 Granulocyte Chemotactic Peptide-Interleukin-8 Chemotactic Peptide-Interleukin-8, Granulocyte Granulocyte Chemotactic Peptide Interleukin 8 IL-8

Below are MeSH descriptors whose meaning is more general than "Interleukin-8".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Chemokines [D12.644.276.374.200]
Chemokines, CXC [D12.644.276.374.200.120]
Interleukin-8 [D12.644.276.374.200.120.800]
Interleukins [D12.644.276.374.465]
Interleukin-8 [D12.644.276.374.465.312]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Chemokines [D12.776.467.374.200]
Chemokines, CXC [D12.776.467.374.200.120]
Interleukin-8 [D12.776.467.374.200.120.800]
Interleukins [D12.776.467.374.465]
Interleukin-8 [D12.776.467.374.465.246]
Biological Factors [D23]
Chemotactic Factors [D23.125]
Chemokines [D23.125.300]
Chemokines, CXC [D23.125.300.120]
Interleukin-8 [D23.125.300.120.800]
Inflammation Mediators [D23.469]
Chemokines [D23.469.200]
Chemokines, CXC [D23.469.200.120]
Interleukin-8 [D23.469.200.120.800]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Chemokines [D23.529.374.200]
Chemokines, CXC [D23.529.374.200.120]
Interleukin-8 [D23.529.374.200.120.800]
Interleukins [D23.529.374.465]
Interleukin-8 [D23.529.374.465.312]

Below are MeSH descriptors whose meaning is more specific than "Interleukin-8".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-8" by people in this website by year, and whether "Interleukin-8" was a major or minor topic of these publications.

Bar chart showing 61 publications over 20 distinct years, with a maximum of 7 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2003	1	2	3
2004	1	2	3
2005	3	1	4
2006	2	3	5
2007	2	4	6
2009	2	1	3
2010	1	2	3
2011	0	2	2
2012	0	2	2
2013	3	2	5
2014	5	2	7
2015	0	4	4
2016	0	4	4
2017	0	2	2
2018	1	0	1
2020	1	2	3
2024	0	1	1
2025	0	1	1

Below are the most recent publications written about "Interleukin-8" by people in Profiles.

Song S, Kim Z, Youn HJ, Cho J, Kim YS, Min JW, Choi SW, Franke AA, Jun S, Joung H, Lee JE. Dietary intake and plasma isoflavones are inversely associated with inflammatory markers in breast cancer survivors: A cross-sectional study. Nutr Res. 2025 Jun; 138:22-32.

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Warner S, Teague HL, Ramos-Benitez MJ, Panicker S, Allen K, Gairhe S, Moyer T, Parachalil Gopalan B, Douagi I, Shet A, Kanthi Y, Suffredini AF, Chertow DS, Strich JR. R406 reduces lipopolysaccharide-induced neutrophil activation. Cell Immunol. 2024 Sep-Oct; 403-404:104860.

View in: PubMed
Mitchell BI, Laws EI, Chow DC, SahBandar IN, Gangcuangco LMA, Shikuma CM, Ndhlovu LC. Increased Monocyte Inflammatory Responses to Oxidized LDL Are Associated with Insulin Resistance in HIV-Infected Individuals on Suppressive Antiretroviral Therapy. Viruses. 2020 10 05; 12(10).

View in: PubMed
Messeha SS, Zarmouh NO, Mendonca P, Cotton C, Soliman KFA. Molecular mechanism of gossypol mediating CCL2 and IL-8 attenuation in triple-negative breast cancer cells. Mol Med Rep. 2020 08; 22(2):1213-1226.

View in: PubMed
Chuang TD, Rehan A, Khorram O. Tranilast induces MiR-200c expression through blockade of RelA/p65 activity in leiomyoma smooth muscle cells. Fertil Steril. 2020 06; 113(6):1308-1318.

View in: PubMed
Devaurs D, Antunes DA, Kavraki LE. Revealing Unknown Protein Structures Using Computational Conformational Sampling Guided by Experimental Hydrogen-Exchange Data. Int J Mol Sci. 2018 Oct 31; 19(11).

View in: PubMed
Encarnaci?n-Medina J, Rodr?guez-Cotto RI, Bloom-Oquendo J, Ortiz-Mart?nez MG, Duconge J, Jim?nez-V?lez B. Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM2.5, Budesonide, and Cotreated Exposures. Mediators Inflamm. 2017; 2017:6827194.

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Takeda K, Tokunaga N, Aida Y, Kajiya M, Ouhara K, Sasaki S, Mizuno N, Fujita T, Kurihara H. Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells. Inflammation. 2017 Feb; 40(1):240-247.

View in: PubMed
Ho MH, Guo ZM, Chunga J, Goodwin JS, Xie H. Characterization of Innate Immune Responses of Human Endothelial Cells Induced by Porphyromonas gingivalis and Their Derived Outer Membrane Vesicles. Front Cell Infect Microbiol. 2016; 6:139.

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Nakamoto K, Watanabe M, Sada M, Inui T, Nakamura M, Honda K, Wada H, Mikami Y, Matsuzaki H, Horie M, Noguchi S, Yamauchi Y, Koyama H, Kogane T, Kohyama T, Takizawa H. Serum Reactive Oxygen Metabolite Levels Predict Severe Exacerbations of Asthma. PLoS One. 2016; 11(10):e0164948.

View in: PubMed

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