Interleukin-4

"Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.

Descriptor ID	D015847
MeSH Number(s)	D12.644.276.374.465.186 D12.776.467.374.465.178 D23.529.374.465.186
Concept/Terms	Interleukin-4 Interleukin-4 Interleukin 4 B-Cell Growth Factor-1 B Cell Growth Factor 1 B-Cell Growth Factor-I B Cell Growth Factor I B-Cell Proliferating Factor B Cell Proliferating Factor B-Cell Stimulating Factor-1 B Cell Stimulating Factor 1 B-Cell Stimulatory Factor 1 B-Cell Stimulatory Factor-1 BCGF-1 Binetrakin BSF-1 IL-4 IL4 Mast Cell Growth Factor-2 Mast Cell Growth Factor 2 MCGF-2 B Cell Stimulatory Factor-1 B Cell Stimulatory Factor 1

Below are MeSH descriptors whose meaning is more general than "Interleukin-4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-4 [D12.644.276.374.465.186]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-4 [D12.776.467.374.465.178]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-4 [D23.529.374.465.186]

Below are MeSH descriptors whose meaning is related to "Interleukin-4".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-4" by people in this website by year, and whether "Interleukin-4" was a major or minor topic of these publications.

Bar chart showing 48 publications over 21 distinct years, with a maximum of 5 publications in 1998 and 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	1	0	1
1996	0	1	1
1997	1	1	2
1998	1	4	5
2000	3	2	5
2001	1	1	2
2002	0	4	4
2003	1	1	2
2004	2	0	2
2005	0	4	4
2006	0	2	2
2007	0	2	2
2008	2	2	4
2010	1	0	1
2011	1	3	4
2012	0	1	1
2016	1	0	1
2017	1	1	2
2018	0	1	1
2022	0	1	1

Below are the most recent publications written about "Interleukin-4" by people in Profiles.

McMillan JKP, O'Donnell P, Chang SP. Pattern recognition receptor ligand-induced differentiation of human transitional B cells. PLoS One. 2022; 17(8):e0273810.

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Trivedi NH, Yu JJ, Hung CY, Doelger RP, Navara CS, Armitige LY, Seshu J, Sinai AP, Chambers JP, Guentzel MN, Arulanandam BP. Microbial co-infection alters macrophage polarization, phagosomal escape, and microbial killing. Innate Immun. 2018 04; 24(3):152-162.

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Gundra UM, Girgis NM, Gonzalez MA, San Tang M, Van Der Zande HJP, Lin JD, Ouimet M, Ma LJ, Poles J, Vozhilla N, Fisher EA, Moore KJ, Loke P. Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation. Nat Immunol. 2017 06; 18(6):642-653.

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Li Z, Liu F, Ma H, White PF, Yumul R, Jiang Y, Wang N, Cao X. Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4. Brain Res. 2017 06 15; 1665:65-73.

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Sharma A, Sharma P, Vishwakarma AL, Srivastava M. Functional Impairment of Murine Dendritic Cell Subsets following Infection with Infective Larval Stage 3 of Brugia malayi. Infect Immun. 2017 Jan; 85(1).

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Li J, Chen XL, Shaker A, Oshima T, Shan J, Miwa H, Feng C, Zhang J. Contribution of immunomodulators to gastroesophageal reflux disease and its complications: stromal cells, interleukin 4, and adiponectin. Ann N Y Acad Sci. 2016 09; 1380(1):183-194.

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Hyacinth HI, Capers PL, Archer DR, Hibbert JM. TNF-a, IFN-?, IL-10, and IL-4 levels were elevated in a murine model of human sickle cell anemia maintained on a high protein/calorie diet. Exp Biol Med (Maywood). 2014 Jan; 239(1):65-70.

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Rodriguez AR, Yu JJ, Guentzel MN, Navara CS, Klose KE, Forsthuber TG, Chambers JP, Berton MT, Arulanandam BP. Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis. J Immunol. 2012 Jun 01; 188(11):5604-11.

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Shi L, Perin JC, Leipzig J, Zhang Z, Sullivan KE. Genome-wide analysis of interferon regulatory factor I binding in primary human monocytes. Gene. 2011 Nov 01; 487(1):21-8.

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Thathiah P, Sanapala S, Rodriguez AR, Yu JJ, Murthy AK, Guentzel MN, Forsthuber TG, Chambers JP, Arulanandam BP. Non-FceR bearing mast cells secrete sufficient interleukin-4 to control Francisella tularensis replication within macrophages. Cytokine. 2011 Aug; 55(2):211-20.

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